CDH3

CDH3
????????? ?????
PDB	?????? ?????????????: PDBe RCSB
????? ????????? PDB
	4OY9
?????????????
??????? ????	CDH3 , CDHP, HJMD, PCAD, cadherin 3
????????? ??????	OMIM: 114021 MGI: 88356 HomoloGene: 20425 GeneCards: CDH3
?????? ?? (???)
????????	???????? ? (???)
?????	107,283,929 bp
????? ????? RNA
	More reference expression data
?????????? ??
?????? ??????	? calcium ion binding ; ? metal ion binding ; ? molecular function ; ? cytoskeletal protein binding ; ? protein homodimerization activity ; ? cadherin binding ;
??????? ?????	? ????????? ; ? integral component of membrane ; ? membrane ; ? ????? ????? ; ? cell surface ; ? catenin complex ;
?????? ?????	? hair cycle process ; ? positive regulation of keratinocyte proliferation ; ? negative regulation of timing of catagen ; ? response to stimulus ; ? keratinization ; ? ????? ??? ; ? regulation of hair cycle by canonical Wnt signaling pathway ; ? negative regulation of transforming growth factor beta2 production ; ? positive regulation of tyrosinase activity ; ? retina homeostasis ; ? GO:1901313 positive regulation of gene expression ; ? ??????? ????? ; ? positive regulation of insulin-like growth factor receptor signaling pathway ; ? canonical Wnt signaling pathway ; ? positive regulation of melanin biosynthetic process ; ? positive regulation of melanosome transport ; ? adherens junction organization ; ? ?????? ; ? homophilic cell adhesion via plasma membrane adhesion molecules ; ? cell-cell adhesion ; ? positive regulation of canonical Wnt signaling pathway ; ? cell-cell junction assembly ; ? calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules ; ? cell-cell adhesion mediated by cadherin ; ? GO:0000767 cell morphogenesis ;
	?????: ????? / ????????
?????????????
	1001
	12560
	ENSG00000062038
	ENSMUSG00000061048
	P22223
	P10287
	NM_001793? NM_001317195? NM_001317196? XM_047433450 XM_011522800? NM_001793? NM_001317195? NM_001317196? XM_047433450
	NM_007665 NM_001037809? NM_007665
	NP_001304125? NP_001784? XP_011521102 NP_001304124? NP_001304125? NP_001784? XP_011521102
	NP_031691 NP_001032898? NP_031691
	?????????
??????/?????? ?????	??????/?????? ???

???????-? ( ??????? : Cadherin-3 ) ?? ?? ??? ??-??????? ?? ?????? ??????? ?? ??????? ??? ?? ?? ????? ???? ?? ≪ CDH3 ≫ ??????? ??????. ^[?]^[?]

??? ?? ??? ?? ?? ???? ≪??????? ???????? ???????? ???????? ??? ??? ???????≫ ?? ?????? ???. ^[?]

???????? ?????? [ ?????? ]

????? [ ?????? ]

↑ ^??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000061048 - Ensembl , May 2017
↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ Kaupmann K, Becker-Follmann J, Scherer G, Jockusch H, Starzinski-Powitz A (Oct 1992). "The gene for the cell adhesion molecule M-cadherin maps to mouse chromosome 8 and human chromosome 16q24.1-qter and is near the E-cadherin (uvomorulin) locus in both species". Genomics . 14 (2): 488?90. doi : 10.1016/S0888-7543(05)80247-2 . PMID 1427864 .
↑ ^??? ^??? "Entrez Gene: CDH3 cadherin 3, type 1, P-cadherin (placental)" .

?????????????? ?????????. ≪ CDH3 (gene) ≫. ?? ????????? ?????????? ??????? ? ??????????? ?? ?? ????? ????.

????? ??????? [ ?????? ]

Herrenknecht K, Ozawa M, Eckerskorn C, Lottspeich F, Lenter M, Kemler R (Oct 1991). "The uvomorulin-anchorage protein alpha catenin is a vinculin homologue" . Proceedings of the National Academy of Sciences of the United States of America . 88 (20): 9156?60. doi : 10.1073/pnas.88.20.9156 . PMC 52671 . PMID 1924379 .
Shimoyama Y, Hirohashi S, Hirano S, Noguchi M, Shimosato Y, Takeichi M, Abe O (Apr 1989). "Cadherin cell-adhesion molecules in human epithelial tissues and carcinomas". Cancer Research . 49 (8): 2128?33. PMID 2702654 .
Shimoyama Y, Yoshida T, Terada M, Shimosato Y, Abe O, Hirohashi S (Oct 1989). "Molecular cloning of a human Ca2+-dependent cell-cell adhesion molecule homologous to mouse placental cadherin: its low expression in human placental tissues" . The Journal of Cell Biology . 109 (4 Pt 1): 1787?94. doi : 10.1083/jcb.109.4.1787 . PMC 2115800 . PMID 2793940 .
Palacios J, Benito N, Pizarro A, Suarez A, Espada J, Cano A, Gamallo C (Mar 1995). "Anomalous expression of P-cadherin in breast carcinoma. Correlation with E-cadherin expression and pathological features" . The American Journal of Pathology . 146 (3): 605?12. PMC 1869170 . PMID 7534041 .
van der Linden PJ, de Goeij AF, Dunselman GA, Erkens HW, Evers JL (Jun 1995). "Expression of cadherins and integrins in human endometrium throughout the menstrual cycle". Fertility and Sterility . 63 (6): 1210?6. doi : 10.1016/s0015-0282(16)57599-2 . PMID 7538474 .
Tang A, Eller MS, Hara M, Yaar M, Hirohashi S, Gilchrest BA (Apr 1994). "E-cadherin is the major mediator of human melanocyte adhesion to keratinocytes in vitro" . Journal of Cell Science . 107 (4): 983?92. PMID 8056851 .
Tassin MT, Beziau A, Gubler MC, Boyer B (Mar 1994). "Spatiotemporal expression of molecules associated with junctional complexes during the in vivo maturation of renal podocytes". The International Journal of Developmental Biology . 38 (1): 45?54. PMID 8074995 .
Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene . 138 (1?2): 171?4. doi : 10.1016/0378-1119(94)90802-8 . PMID 8125298 .
Navarro P, Lozano E, Cano A (Aug 1993). "Expression of E- or P-cadherin is not sufficient to modify the morphology and the tumorigenic behavior of murine spindle carcinoma cells. Possible involvement of plakoglobin". Journal of Cell Science . 105 (4): 923?34. PMID 8227214 .
Reynolds AB, Daniel JM, Mo YY, Wu J, Zhang Z (Jun 1996). "The novel catenin p120cas binds classical cadherins and induces an unusual morphological phenotype in NIH3T3 fibroblasts". Experimental Cell Research . 225 (2): 328?37. doi : 10.1006/excr.1996.0183 . PMID 8660921 .
Soler AP, Harner GD, Knudsen KA, McBrearty FX, Grujic E, Salazar H, Han AC, Keshgegian AA (Aug 1997). "Expression of P-cadherin identifies prostate-specific-antigen-negative cells in epithelial tissues of male sexual accessory organs and in prostatic carcinomas. Implications for prostate cancer biology" . The American Journal of Pathology . 151 (2): 471?8. PMC 1858007 . PMID 9250159 .
Wakita H, Furukawa F, Baba S, Takigawa M (Nov 1997). "Human squamous-cell-carcinoma cell line (DJM-1) cells synthesize P-cadherin molecules via an elevation of extracellular calcium: calcium regulates P-cadherin-gene expression at the translational level via protein tyrosine phosphorylation". International Journal of Cancer . 73 (3): 432?9. doi : 10.1002/(SICI)1097-0215(19971104)73:3<432::AID-IJC19>3.0.CO;2-E . PMID 9359492 .
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene . 200 (1?2): 149?56. doi : 10.1016/S0378-1119(97)00411-3 . PMID 9373149 .
Kremmidiotis G, Baker E, Crawford J, Eyre HJ, Nahmias J, Callen DF (May 1998). "Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity". Genomics . 49 (3): 467?71. doi : 10.1006/geno.1998.5281 . PMID 9615235 .
Jarrard DF, Paul R, van Bokhoven A, Nguyen SH, Bova GS, Wheelock MJ, Johnson KR, Schalken J, Bussemakers M, Isaacs WB (Nov 1997). "P-Cadherin is a basal cell-specific epithelial marker that is not expressed in prostate cancer". Clinical Cancer Research . 3 (11): 2121?8. PMID 9815605 .
Schmeiser K, Grand RJ (Apr 1999). "The fate of E- and P-cadherin during the early stages of apoptosis". Cell Death and Differentiation . 6 (4): 377?86. doi : 10.1038/sj.cdd.4400504 . PMID 10381631 .
Rufas O, Fisch B, Ziv S, Shalgi R (Feb 2000). "Expression of cadherin adhesion molecules on human gametes". Molecular Human Reproduction . 6 (2): 163?9. doi : 10.1093/molehr/6.2.163 . PMID 10655458 .
Klingelhofer J, Troyanovsky RB, Laur OY, Troyanovsky S (Aug 2000). "Amino-terminal domain of classic cadherins determines the specificity of the adhesive interactions". Journal of Cell Science . 113 (16): 2829?36. PMID 10910767 .
Han AC, Edelson MI, Peralta Soler A, Knudsen KA, Lifschitz-Mercer B, Czernobilsky B, Rosenblum NG, Salazar H (Nov 2000). "Cadherin expression in glandular tumors of the cervix". Cancer . 89 (10): 2053?8. doi : 10.1002/1097-0142(20001115)89:10<2053::AID-CNCR4>3.0.CO;2-C . PMID 11066045 .
Bauer K, Gosau M, Reinders J, Oefner P, Reichert TE, Bauer R (Nov 2013). "Presenilin 1/γ-secretase modulates P-cadherin processing and influences cell adhesion in oral squamous cell carcinoma cell lines". Carcinogenesis . 34 (11): 2622?8. doi : 10.1093/carcin/bgt211 . PMID 23740836 .

????? ?? ????? [ ?????? ]

???? ?? ?????? CDH3 ?? ?????? ????? UCSC.
?????? ?? ?????? CDH3 ?? ?????? ????? UCSC.

??? ?? ?????? ??? ?????????? ??????? ???. ????????? ?? ????? ?? ?? ????????? ??? ????.

[refGRCm38Ensembl-1] ??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000061048 - Ensembl , May 2017

[2] "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[3] "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[pmid1427864-4] Kaupmann K, Becker-Follmann J, Scherer G, Jockusch H, Starzinski-Powitz A (Oct 1992). "The gene for the cell adhesion molecule M-cadherin maps to mouse chromosome 8 and human chromosome 16q24.1-qter and is near the E-cadherin (uvomorulin) locus in both species". Genomics . 14 (2): 488?90. doi : 10.1016/S0888-7543(05)80247-2 . PMID 1427864 .

[entrez-5] ??? ^??? "Entrez Gene: CDH3 cadherin 3, type 1, P-cadherin (placental)" .

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