CD30

TNFRSF8
????????? ?????
PDB	?????? ?????????????: PDBe RCSB
????? ????????? PDB
	1D01
?????????????
??????? ????	TNFRSF8 , CD30, D1S166E, Ki-1, tumor necrosis factor receptor superfamily member 8, TNF receptor superfamily member 8
????????? ??????	OMIM: 153243 MGI: 99908 HomoloGene: 949 GeneCards: TNFRSF8
?????? ?? (???)
????????	???????? ? (???)
?????	145,041,734 bp
????? ????? RNA
	More reference expression data
?????????? ??
?????? ??????	? transmembrane signaling receptor activity ; ? tumor necrosis factor-activated receptor activity ; ? nerve growth factor binding ;
??????? ?????	? ????????? ; ? integral component of membrane ; ? integral component of plasma membrane ; ? extracellular exosome ; ? membrane ; ? ????? ????? ; ? ???? ????? ; ? neuron projection ;
?????? ?????	? apoptotic signaling pathway ; ? cellular response to mechanical stimulus ; ? response to lipopolysaccharide ; ? inflammatory response ; ? GO:0046730? GO:0046737? GO:0046738? GO:0046736 ???? ????? ; ? GO:0072468 ???????? ???? ; ? negative regulation of cell population proliferation ; ? positive regulation of apoptotic process ; ? tumor necrosis factor-mediated signaling pathway ; ? ????? ??? ; ? negative regulation of neuron projection development ; ? positive regulation of NF-kappaB transcription factor activity ;
	?????: ????? / ????????
?????????????
	943
	21941
	ENSG00000120949
	ENSMUSG00000028602
	P28908
	Q60846
	NM_001281430? NM_152942? XM_011542441? XM_011542443? XM_047434793? XM_047434799 NM_001243? NM_001281430? NM_152942? XM_011542441? XM_011542443? XM_047434793? XM_047434799
	XM_036163966 NM_009401? XM_036163966
	NP_001268359? XP_011540743? XP_011540745 NP_001234? NP_001268359? XP_011540743? XP_011540745
	XP_036019859 NP_033427? XP_036019859
	?????????
??????/?????? ?????	??????/?????? ???

??????? ?????? ?? ( ??????? : Cluster of Differentiation 30 ) ?? ????????? ≪ CD30 ≫ ?? ?? ??? ≪ TNFRSF8 ≫ ?? ?????? ??????? ???????? ?? ???????? ???? ?????? ????? ????? ? ?????? ?? ?????? ????? ???.

??? ??????? ?? ??? ??? ??????????? ?? ? ??????????? ?? ???? ???? ??????.

??? ?????? ???????? ?? ????? ≪????? ?????????? ???? ????≫ (ALCL) ?? ?????? ???. ??? ??????? ?? ≪???????? ??????????≫ (? ?? ?? ≪???????≫) ???? ?????? ? ??????? ?? ?? ???????? ?? ?????? ????? ?? ?????? ???????? ???? ???? (Germ cell tumor) ??????? ???. ^[?] CD30 ? CD15 ?? ???????? ???-???????? ????? ?????? ?? ???? ???????. ^[?]

????? [ ?????? ]

↑ ^??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000028602 - Ensembl , May 2017
↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ Teng LH, Lu DH, Xu QZ, Fu YJ, Yang H, He ZL (Nov 2005). "[Expression and diagnostic significance of OCT4, CD117 and CD30 in germ cell tumors]". Zhonghua Bing Li Xue Za Zhi Chinese Journal of Pathology (?? ????). 34 (11): 711?5. PMID 16536313 .
↑ Gorczyca W, Tsang P, Liu Z, Wu CD, Dong HY, Goldstein M, Cohen P, Gangi M, Weisberger J (Feb 2003). "CD30-positive T-cell lymphomas co-expressing CD15: an immunohistochemical analysis". International Journal of Oncology . 22 (2): 319?24. doi : 10.3892/ijo.22.2.319 . PMID 12527929 .

?????????????? ?????????. ≪ CD30 ≫. ?? ????????? ?????????? ??????? ? ??????????? ?? ?? ?????? ????.

????? ??????? [ ?????? ]

Schneider C, Hubinger G (Jul 2002). "Pleiotropic signal transduction mediated by human CD30: a member of the tumor necrosis factor receptor (TNFR) family". Leukemia & Lymphoma . 43 (7): 1355?66. doi : 10.1080/10428190290033288 . PMID 12389614 .
Horie R, Higashihara M, Watanabe T (Jan 2003). "Hodgkin's lymphoma and CD30 signal transduction". International Journal of Hematology . 77 (1): 37?47. doi : 10.1007/BF02982601 . PMID 12568298 .
Tarkowski M (Jul 2003). "Expression and a role of CD30 in regulation of T-cell activity". Current Opinion in Hematology . 10 (4): 267?71. doi : 10.1097/00062752-200307000-00003 . PMID 12799531 .
Granados S, Hwang ST (Jun 2004). "Roles for CD30 in the biology and treatment of CD30 lymphoproliferative diseases" . The Journal of Investigative Dermatology . 122 (6): 1345?7. doi : 10.1111/j.0022-202X.2004.22616.x . PMID 15175022 .
Durkop H, Latza U, Hummel M, Eitelbach F, Seed B, Stein H (Feb 1992). "Molecular cloning and expression of a new member of the nerve growth factor receptor family that is characteristic for Hodgkin's disease". Cell . 68 (3): 421?7. doi : 10.1016/0092-8674(92)90180-K . PMID 1310894 .
Fonatsch C, Latza U, Durkop H, Rieder H, Stein H (Nov 1992). "Assignment of the human CD30 (Ki-1) gene to 1p36". Genomics . 14 (3): 825?6. doi : 10.1016/S0888-7543(05)80203-4 . PMID 1330892 .
Josimovic-Alasevic O, Durkop H, Schwarting R, Backe E, Stein H, Diamantstein T (Jan 1989). "Ki-1 (CD30) antigen is released by Ki-1-positive tumor cells in vitro and in vivo. I. Partial characterization of soluble Ki-1 antigen and detection of the antigen in cell culture supernatants and in serum by an enzyme-linked immunosorbent assay". European Journal of Immunology . 19 (1): 157?62. doi : 10.1002/eji.1830190125 . PMID 2537734 .
Stein H, Gerdes J, Schwab U, Lemke H, Mason DY, Ziegler A, Schienle W, Diehl V (Oct 1982). "Identification of Hodgkin and Sternberg-reed cells as a unique cell type derived from a newly-detected small-cell population". International Journal of Cancer . 30 (4): 445?59. doi : 10.1002/ijc.2910300411 . PMID 6754630 .
Jung W, Krueger S, Renner C, Gause A, Sahin U, Trumper L, Pfreundschuh M (Dec 1994). "Opposite effects of the CD30 ligand are not due to CD30 mutations: results from cDNA cloning and sequence comparison of the CD30 antigen from different sources" . Molecular Immunology . 31 (17): 1329?34. doi : 10.1016/0161-5890(94)90051-5 . PMID 7527901 .
Shiota M, Fujimoto J, Semba T, Satoh H, Yamamoto T, Mori S (Jun 1994). "Hyperphosphorylation of a novel 80 kDa protein-tyrosine kinase similar to Ltk in a human Ki-1 lymphoma cell line, AMS3" . Oncogene . 9 (6): 1567?74. PMID 8183550 .
Lee SY, Park CG, Choi Y (Feb 1996). "T cell receptor-dependent cell death of T cell hybridomas mediated by the CD30 cytoplasmic domain in association with tumor necrosis factor receptor-associated factors" . The Journal of Experimental Medicine . 183 (2): 669?74. doi : 10.1084/jem.183.2.669 . PMC 2192463 . PMID 8627180 .
Gedrich RW, Gilfillan MC, Duckett CS, Van Dongen JL, Thompson CB (May 1996). "CD30 contains two binding sites with different specificities for members of the tumor necrosis factor receptor-associated factor family of signal transducing proteins". The Journal of Biological Chemistry . 271 (22): 12852?8. doi : 10.1074/jbc.271.22.12852 . PMID 8662842 .
Horie R, Ito K, Tatewaki M, Nagai M, Aizawa S, Higashihara M, Ishida T, Inoue J, Takizawa H, Watanabe T (Oct 1996). "A variant CD30 protein lacking extracellular and transmembrane domains is induced in HL-60 by tetradecanoylphorbol acetate and is expressed in alveolar macrophages". Blood . 88 (7): 2422?32. PMID 8839832 .
Aizawa S, Nakano H, Ishida T, Horie R, Nagai M, Ito K, Yagita H, Okumura K, Inoue J, Watanabe T (Jan 1997). "Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation". The Journal of Biological Chemistry . 272 (4): 2042?5. doi : 10.1074/jbc.272.4.2042 . PMID 8999898 .
Lee SY, Lee SY, Choi Y (Apr 1997). "TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation" . The Journal of Experimental Medicine . 185 (7): 1275?85. doi : 10.1084/jem.185.7.1275 . PMC 2196258 . PMID 9104814 .
Boucher LM, Marengere LE, Lu Y, Thukral S, Mak TW (Apr 1997). "Binding sites of cytoplasmic effectors TRAF1, 2, and 3 on CD30 and other members of the TNF receptor superfamily". Biochemical and Biophysical Research Communications . 233 (3): 592?600. doi : 10.1006/bbrc.1997.6509 . PMID 9168896 .
Duckett CS, Thompson CB (Nov 1997). "CD30-dependent degradation of TRAF2: implications for negative regulation of TRAF signaling and the control of cell survival" . Genes & Development . 11 (21): 2810?21. doi : 10.1101/gad.11.21.2810 . PMC 316646 . PMID 9353251 .
Mizushima S, Fujita M, Ishida T, Azuma S, Kato K, Hirai M, Otsuka M, Yamamoto T, Inoue J (Jan 1998). "Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5)". Gene . 207 (2): 135?40. doi : 10.1016/S0378-1119(97)00616-1 . PMID 9511754 .
Kurts C, Carbone FR, Krummel MF, Koch KM, Miller JF, Heath WR (Mar 1999). "Signalling through CD30 protects against autoimmune diabetes mediated by CD8 T cells". Nature . 398 (6725): 341?4. doi : 10.1038/18692 . PMID 10192335 .

????? ?? ????? [ ?????? ]

CD30 Antigens ?? ??????????? ?????? ????? (MeSH) ?? ????????? ??? ????? ?????? ?????? ??????
???? ???? TNFRSF8 ?????? ? ????? ?????? ??? TNFRSF8 ?? ?????? ?????? ???? ??? ??????? ?????????? ????? ???? .

??? ?? ?????? ??? ?????????? ??????? ???. ????????? ?? ????? ?? ?? ????????? ??? ????.

[refGRCm38Ensembl-1] ??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000028602 - Ensembl , May 2017

[2] "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[3] "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[4] Teng LH, Lu DH, Xu QZ, Fu YJ, Yang H, He ZL (Nov 2005). "[Expression and diagnostic significance of OCT4, CD117 and CD30 in germ cell tumors]". Zhonghua Bing Li Xue Za Zhi Chinese Journal of Pathology (?? ????). 34 (11): 711?5. PMID 16536313 .

[5] Gorczyca W, Tsang P, Liu Z, Wu CD, Dong HY, Goldstein M, Cohen P, Gangi M, Weisberger J (Feb 2003). "CD30-positive T-cell lymphomas co-expressing CD15: an immunohistochemical analysis". International Journal of Oncology . 22 (2): 319?24. doi : 10.3892/ijo.22.2.319 . PMID 12527929 .

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