CD248

CD248
?????????????
??????? ????	CD248 , CD164L1, TEM1, CD248 molecule
????????? ??????	OMIM: 606064 MGI: 1917695 HomoloGene: 10699 GeneCards: CD248
?????? ?? (???)
????????	???????? ?? (???)
?????	5,120,710 bp
????? ????? RNA
	More reference expression data
?????????? ??
?????? ??????	? calcium ion binding ; ? extracellular matrix binding ; ? carbohydrate binding ; ? molecular function ; ? extracellular matrix protein binding ;
??????? ?????	? ????????? ; ? integral component of membrane ; ? extracellular exosome ; ? membrane ; ? GO:0005578 ????????? ????????????? ; ? external side of plasma membrane ;
?????? ?????	? positive regulation of endothelial cell apoptotic process ; ? lymph node development ; ? ??? ????? ; ? positive regulation of cell population proliferation ; ? anatomical structure regression ; ? GO:0022610 biological process ;
	?????: ????? / ????????
?????????????
	57124
	70445
	ENSG00000174807
	ENSMUSG00000056481
	Q9HCU0
	Q91V98
	NM_020404
	NM_054042
	NP_065137
	NP_473383
	?????????
??????/?????? ?????	??????/?????? ???

?????????? ( ??????? : Endosialin ) ?? ??????? ??? ?? ?? ????? ???? ?? ?? ≪ CD248 ≫ ???????? ??????. ^[?]^[?]^[?]

??? ??????? ???? ?? ???? ?? ???????? ????? ??? ?? ??? ?? ?? ????????? ??????? ???? ??? ????. ?????????? ?? ??????? ????? ?????? ? ???????? ?????? ??? ????. ^[?]

???????? ?????? [ ?????? ]

?????? ??????

????? [ ?????? ]

↑ ^??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000056481 - Ensembl , May 2017
↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ St Croix B, Rago C, Velculescu V, Traverso G, Romans KE, Montgomery E, Lal A, Riggins GJ, Lengauer C, Vogelstein B, Kinzler KW (Aug 2000). "Genes expressed in human tumor endothelium". Science . 289 (5482): 1197?202. doi : 10.1126/science.289.5482.1197 . PMID 10947988 .
↑ Christian S, Ahorn H, Koehler A, Eisenhaber F, Rodi HP, Garin-Chesa P, Park JE, Rettig WJ, Lenter MC (May 2001). "Molecular cloning and characterization of endosialin, a C-type lectin-like cell surface receptor of tumor endothelium". J Biol Chem . 276 (10): 7408?14. doi : 10.1074/jbc.M009604200 . PMID 11084048 .
↑ "Entrez Gene: CD248 CD248 molecule, endosialin" .
↑ Rupp C, Dolznig H, Puri C, Sommergruber W, Kerjaschki D, Rettig WJ, Garin-Chesa P (2006). "Mouse endosialin, a C-type lectin-like cell surface receptor: expression during embryonic development and induction in experimental cancer neoangiogenesis". Cancer Immun . 6 : 10. PMID 16875435 .

?????????????? ?????????. ≪ CD248 ≫. ?? ????????? ?????????? ??????? ? ??????????? ?? ?? ??????? ????.

???? ??????? ????? [ ?????? ]

Rettig WJ, Garin-Chesa P, Healey JH, et al. (1992). "Identification of endosialin, a cell surface glycoprotein of vascular endothelial cells in human cancer" . Proc. Natl. Acad. Sci. U.S.A . 89 (22): 10832?6. doi : 10.1073/pnas.89.22.10832 . PMC 50436 . PMID 1438285 .
Opavsky R, Haviernik P, Jurkovicova D, et al. (2001). "Molecular characterization of the mouse Tem1/endosialin gene regulated by cell density in vitro and expressed in normal tissues in vivo". J. Biol. Chem . 276 (42): 38795?807. doi : 10.1074/jbc.M105241200 . PMID 11489895 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899?903. doi : 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet . 36 (1): 40?5. doi : 10.1038/ng1285 . PMID 14702039 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121?7. doi : 10.1101/gr.2596504 . PMC 528928 . PMID 15489334 .
Brady J, Neal J, Sadakar N, Gasque P (2005). "Human endosialin (tumor endothelial marker 1) is abundantly expressed in highly malignant and invasive brain tumors". J. Neuropathol. Exp. Neurol . 63 (12): 1274?83. doi : 10.1093/jnen/63.12.1274 . PMID 15624764 .
MacFadyen JR, Haworth O, Roberston D, et al. (2005). "Endosialin (TEM1, CD248) is a marker of stromal fibroblasts and is not selectively expressed on tumour endothelium". FEBS Lett . 579 (12): 2569?75. doi : 10.1016/j.febslet.2005.03.071 . PMID 15862292 .
Dolznig H, Schweifer N, Puri C, et al. (2006). "Characterization of cancer stroma markers: in silico analysis of an mRNA expression database for fibroblast activation protein and endosialin". Cancer Immun . 5 : 10. PMID 16076089 .
Tomkowicz B, Rybinski K, Foley B, et al. (2008). "Interaction of endosialin/TEM1 with extracellular matrix proteins mediates cell adhesion and migration" . Proc. Natl. Acad. Sci. U.S.A . 104 (46): 17965?70. doi : 10.1073/pnas.0705647104 . PMC 2084280 . PMID 17986615 .

????? ?? ????? [ ?????? ]

CD248 protein, human ?? ??????????? ?????? ????? (MeSH) ?? ????????? ??? ????? ?????? ?????? ??????
???? ???? CD248 ?????? ? ????? ?????? ??? CD248 ?? ?????? ?????? ???? ??? ??????? ?????????? ????? ???? .

??? ?? ?????? ??? ?????????? ??????? ???. ????????? ?? ????? ?? ?? ????????? ??? ????.

[refGRCm38Ensembl-1] ??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000056481 - Ensembl , May 2017

[2] "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[3] "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[pmid10947988-4] St Croix B, Rago C, Velculescu V, Traverso G, Romans KE, Montgomery E, Lal A, Riggins GJ, Lengauer C, Vogelstein B, Kinzler KW (Aug 2000). "Genes expressed in human tumor endothelium". Science . 289 (5482): 1197?202. doi : 10.1126/science.289.5482.1197 . PMID 10947988 .

[pmid11084048-5] Christian S, Ahorn H, Koehler A, Eisenhaber F, Rodi HP, Garin-Chesa P, Park JE, Rettig WJ, Lenter MC (May 2001). "Molecular cloning and characterization of endosialin, a C-type lectin-like cell surface receptor of tumor endothelium". J Biol Chem . 276 (10): 7408?14. doi : 10.1074/jbc.M009604200 . PMID 11084048 .

[entrez-6] "Entrez Gene: CD248 CD248 molecule, endosialin" .

[7] Rupp C, Dolznig H, Puri C, Sommergruber W, Kerjaschki D, Rettig WJ, Garin-Chesa P (2006). "Mouse endosialin, a C-type lectin-like cell surface receptor: expression during embryonic development and induction in experimental cancer neoangiogenesis". Cancer Immun . 6 : 10. PMID 16875435 .

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