CBX2

CBX2
????????? ?????
PDB	?????? ?????????????: PDBe RCSB
????? ????????? PDB
	2D9U , 3H91 , 5EPK
?????????????
??????? ????	CBX2 , CDCA6, M33, SRXY5, chromobox 2
????????? ??????	OMIM: 602770 MGI: 88289 HomoloGene: 7256 GeneCards: CBX2
?????? ?? (???)
????????	???????? ?? (???)
?????	118,922,096 bp
????? ????? RNA
	; ;
	More reference expression data
?????????? ??
?????? ??????	? DNA binding ; ? methylated histone binding ; ? chromatin binding ; ? GO:0001948? GO:0016582 ????? ???????? ;
??????? ?????	? GO:0035328 heterochromatin ; ? GO:0035327 euchromatin ; ? PcG protein complex ; ? PRC1 complex ; ? ???? ????? ; ? ??????????? ; ? ???????? ;
?????? ?????	? ??????? ?????? ; ? development of primary sexual characteristics ; ? sex differentiation ; ? GO:0009373 regulation of transcription, DNA-templated ; ? GO:1901227 negative regulation of transcription by RNA polymerase II ; ? transcription, DNA-templated ; ? GO:0031497? GO:0006336? GO:0034724? GO:0001301? GO:0007580? GO:0034652? GO:0010847 chromatin organization ;
	?????: ????? / ????????
?????????????
	84733
	12416
	ENSG00000173894
	ENSMUSG00000025577
	Q14781
	P30658
	NM_005189? NM_032647? XM_011525382? XM_047436946 XM_011525383? NM_005189? NM_032647? XM_011525382? XM_047436946
	XM_006532103? XM_006532104? XM_006532105 NM_007623? XM_006532103? XM_006532104? XM_006532105
	NP_116036? XP_011523684? XP_011523685 NP_005180? NP_116036? XP_011523684? XP_011523685
	XP_006532166? XP_006532167? XP_006532168 NP_031649? XP_006532166? XP_006532167? XP_006532168
	?????????
??????/?????? ?????	??????/?????? ???

??????? ? ??????? ????????? ( ??????? : Chromobox protein homolog 2 ) ?? ??????? ??? ?? ?? ????? ???? ?? ≪ CBX2 ≫ ???????? ??????. ^[?]^[?]^[?]

?? ??????????? ?? ????? ??? ???????? ??? ??? ??? ????? ?? ???????????? X ? Y ?? ??? ????? ????? ????? ????????. ^[?]

?? CBX2 ?? RYBP ????? ???????-??????? ????. ^[?] ??? ?? ?????? ?? ???? ????? ???? ?? ???? ?? SRY ???? ?? ???????? Y ????? ??????? ????? ???? ? ?? ??? ??? ????? ???? ????? ????? ???? ????? ???.

????? [ ?????? ]

↑ ^??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000025577 - Ensembl , May 2017
↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ Gecz J, Gaunt SJ, Passage E, Burton RD, Cudrey C, Pearce JJ, Fontes M (Jul 1995). "Assignment of a Polycomb-like chromobox gene (CBX2) to human chromosome 17q25". Genomics . 26 (1): 130?3. doi : 10.1016/0888-7543(95)80091-Y . PMID 7782071 .
↑ Chodak GW (Nov 1989). "Early detection and screening for prostatic cancer". Urology . 34 (4 Suppl): 10?2, discussion 46?56. doi : 10.1016/0090-4295(89)90228-8 . PMID 2477932 .
↑ "Entrez Gene: CBX2 chromobox homolog 2 (Pc class homolog, Drosophila)" .
↑ Ewen Callaway. "Girl with Y chromosome sheds light on maleness " , New Scientist , 2009-04-09. Retrieved on 2009-04-14.
↑ Garcia E, Marcos-Gutierrez C, del Mar Lorente M, Moreno JC, Vidal M (Jun 1999). "RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1" . EMBO J . 18 (12): 3404?18. doi : 10.1093/emboj/18.12.3404 . PMC 1171420 . PMID 10369680 .

?????????????? ?????????. ≪ CBX2 (gene) ≫. ?? ????????? ?????????? ??????? ? ??????????? ?? ?? ???? ????.

????? ?? ????? [ ?????? ]

???? ???? CBX2 ?????? ? ????? ?????? ??? CBX2 ?? ?????? ?????? ???? ??? ??????? ?????????? ????? ???? .

???? ??????? ????? [ ?????? ]

Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173?8. doi : 10.1038/nature04209 . PMID 16189514 .
Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation" . Nat. Biotechnol . 22 (6): 707?16. doi : 10.1038/nbt971 . PMID 15146197 .
Garcia E, Marcos-Gutierrez C, del Mar Lorente M, Moreno JC, Vidal M (1999). "RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1" . EMBO J . 18 (12): 3404?18. doi : 10.1093/emboj/18.12.3404 . PMC 1171420 . PMID 10369680 .
Katoh-Fukui Y, Tsuchiya R, Shiroishi T, Nakahara Y, Hashimoto N, Noguchi K, Higashinakagawa T (1998). "Male-to-female sex reversal in M33 mutant mice". Nature . 393 (6686): 688?92. doi : 10.1038/31482 . PMID 9641679 .
Pearce JJ, Singh PB, Gaunt SJ (1992). "The mouse has a Polycomb-like chromobox gene". Development . 114 (4): 921?9. PMID 1352241 .

??? ?? ?????? ??? ?????????? ??????? ???. ????????? ?? ????? ?? ?? ????????? ??? ????.

[refGRCm38Ensembl-1] ??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000025577 - Ensembl , May 2017

[2] "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[3] "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[pmid7782071-4] Gecz J, Gaunt SJ, Passage E, Burton RD, Cudrey C, Pearce JJ, Fontes M (Jul 1995). "Assignment of a Polycomb-like chromobox gene (CBX2) to human chromosome 17q25". Genomics . 26 (1): 130?3. doi : 10.1016/0888-7543(95)80091-Y . PMID 7782071 .

[pmid2477932-5] Chodak GW (Nov 1989). "Early detection and screening for prostatic cancer". Urology . 34 (4 Suppl): 10?2, discussion 46?56. doi : 10.1016/0090-4295(89)90228-8 . PMID 2477932 .

[entrez-6] "Entrez Gene: CBX2 chromobox homolog 2 (Pc class homolog, Drosophila)" .

[7] Ewen Callaway. "Girl with Y chromosome sheds light on maleness " , New Scientist , 2009-04-09. Retrieved on 2009-04-14.

[pmid10369680-8] Garcia E, Marcos-Gutierrez C, del Mar Lorente M, Moreno JC, Vidal M (Jun 1999). "RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1" . EMBO J . 18 (12): 3404?18. doi : 10.1093/emboj/18.12.3404 . PMC 1171420 . PMID 10369680 .

[?]

[?]

[?]

[?]

[?]

[?]

[?]

[?]