CALCRL

CALCRL
????????? ?????
PDB	?????? ?????????????: PDBe RCSB
????? ????????? PDB
	3AQF , 3N7P , 3N7R , 3N7S , 4RWF
?????????????
??????? ????	CALCRL , CGRPR, CRLR, calcitonin receptor like receptor, LMPHM8
????????? ??????	OMIM: 114190 MGI: 1926944 HomoloGene: 21179 GeneCards: CALCRL
?????? ?? (???)
????????	???????? ? (???)
?????	84,255,755 bp
????? ????? RNA
	; ;
	More reference expression data
?????????? ??
?????? ??????	? G protein-coupled receptor activity ; ? calcitonin receptor activity ; ? signal transducer activity ; ? GO:0001948? GO:0016582 ????? ???????? ; ? transmembrane signaling receptor activity ; ? adrenomedullin receptor activity ; ? calcitonin gene-related peptide receptor activity ; ? adrenomedullin binding ;
??????? ?????	? integral component of membrane ; ? ??????? ; ? membrane ; ? ????? ????? ; ? integral component of plasma membrane ; ? ???? ?????????? ; ? ????????? ; ? ????????? ; ? adrenomedullin receptor complex ; ? CGRP receptor complex ;
?????? ?????	? negative regulation of smooth muscle contraction ; ? G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger ; ? receptor internalization ; ? cellular response to sucrose stimulus ; ? heart development ; ? cell surface receptor signaling pathway ; ? ??????? ; ? positive regulation of cell population proliferation ; ? protein transport ; ? negative regulation of inflammatory response ; ? calcium ion transport ; ? GO:0072468 ???????? ???? ; ? positive regulation of smooth muscle cell proliferation ; ? G protein-coupled receptor signaling pathway ; ? adenylate cyclase-activating G protein-coupled receptor signaling pathway ; ? calcitonin gene-related peptide receptor signaling pathway ; ? adrenomedullin receptor signaling pathway ;
	?????: ????? / ????????
?????????????
	10203
	54598
	ENSG00000064989
	ENSMUSG00000059588
	Q16602
	Q9R1W5
	NM_005795? XM_005246232? NM_001369434? NM_001369435? XM_047442888 NM_001271751? NM_005795? XM_005246232? NM_001369434? NM_001369435? XM_047442888
	XM_006499918? XM_036162403 NM_018782? XM_006499918? XM_036162403
	NP_005786? XP_005246289? XP_005246291? NP_001356363? NP_001356364 NP_001258680? NP_005786? XP_005246289? XP_005246291? NP_001356363? NP_001356364
	XP_006499981? XP_036018296 NP_061252? XP_006499981? XP_036018296
	?????????
??????/?????? ?????	??????/?????? ???

??? ??????? ?????????? ( ??????? : CALCRL ) ?? ?? ??? ??????? ??? ??????? ?????????? (CRLR) ?? ?????? ??????? ?? ??????? ??? ?? ?? ????? ???? ?? ≪ CALCRL ≫ ???????? ??????. ^[?]

??? ???????? ?? ?????? ???? ????? ?????? ?? ?? ?????????? (CGRP) ???. ??? ????? ?? ?? ??? ???? ????? ??? ?? ?????????? ?????? ????? ????? ?? ?? ?????????? ???? ??? ?? ????? ????? ??? ????? ?????. ^[?]

?? ??????? ?????????? ????? ?????? ?? ?? ?????????? ????? ?? ????????? ???? ? ?????? ????? ?? ??????? ??????? ?? ?? ???????? ????? ?????? ????. ??? ??? ???? ??????????? ???? ?????????? ??????? ??? ???? ??????????? ?????? ????????? ????? ??? ????? ?? ??? ??? ???? ??????. ?? ???????? ???? ???????? ??? ?? ???? ?????????? ?????? ????? ?? ????????? ?? ???? ??????? ??? ?????? ????? ?????? ?? ?? ?????????? ?? ???? ?????? ? ?? ????? ????? ????? ??? ??????? ???? ????????? ?? ????? ???? ? ?????? ???? ????? ??????. ^[?]

????? [ ?????? ]

↑ ^??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000059588 - Ensembl , May 2017
↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ Aiyar N, Rand K, Elshourbagy NA, Zeng Z, Adamou JE, Bergsma DJ, Li Y (May 1996). "A cDNA encoding the calcitonin gene-related peptide type 1 receptor". J. Biol. Chem . 271 (19): 11325?9. doi : 10.1074/jbc.271.19.11325 . PMID 8626685 .
↑ Edvinsson L, Warfvinge K (2013). "CGRP receptor antagonism and migraine therapy". Current Protein & Peptide Science . 14 (5): 386?92. doi : 10.2174/13892037113149990055 . PMID 23745702 .
↑ https://medicalxpress.com/news/2018-05-germ-flesh-eating-disease-hijacks-neurons.html

?????????????? ?????????. ≪ CALCRL ≫. ?? ????????? ?????????? ??????? ? ??????????? ?? ?? ?????? ????.

???? ??????? ????? [ ?????? ]

Born W, Muff R, Fischer JA (2002). "Functional interaction of G protein-coupled receptors of the adrenomedullin peptide family with accessory receptor-activity-modifying proteins (RAMP)". Microsc. Res. Tech . 57 (1): 14?22. doi : 10.1002/jemt.10051 . PMID 11921352 .
Yallampalli C, Chauhan M, Thota CS, et al. (2003). "Calcitonin gene-related peptide in pregnancy and its emerging receptor heterogeneity". Trends Endocrinol. Metab . 13 (6): 263?9. doi : 10.1016/s1043-2760(02)00563-5 . PMID 12128288 .
Foord SM, Craig RK (1988). "Isolation and characterisation of a human calcitonin-gene-related-peptide receptor". Eur. J. Biochem . 170 (1?2): 373?9. doi : 10.1111/j.1432-1033.1987.tb13710.x . PMID 2826160 .
Skofitsch G, Jacobowitz DM (1986). "Autoradiographic distribution of 125I calcitonin gene-related peptide binding sites in the rat central nervous system". Peptides . 6 (5): 975?86. doi : 10.1016/0196-9781(85)90331-6 . PMID 3001670 .
Fluhmann B, Muff R, Hunziker W, et al. (1995). "A human orphan calcitonin receptor-like structure". Biochem. Biophys. Res. Commun . 206 (1): 341?7. doi : 10.1006/bbrc.1995.1047 . PMID 7818539 .
Aiyar N, Rand K, Elshourbagy NA, et al. (1996). "A cDNA encoding the calcitonin gene-related peptide type 1 receptor". J. Biol. Chem . 271 (19): 11325?9. doi : 10.1074/jbc.271.19.11325 . PMID 8626685 .
McLatchie LM, Fraser NJ, Main MJ, et al. (1998). "RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor". Nature . 393 (6683): 333?9. doi : 10.1038/30666 . PMID 9620797 .
Sams A, Jansen-Olesen I (1999). "Expression of calcitonin receptor-like receptor and receptor-activity-modifying proteins in human cranial arteries". Neurosci. Lett . 258 (1): 41?4. doi : 10.1016/S0304-3940(98)00844-1 . PMID 9876047 .
Kamitani S, Asakawa M, Shimekake Y, et al. (1999). "The RAMP2/CRLR complex is a functional adrenomedullin receptor in human endothelial and vascular smooth muscle cells". FEBS Lett . 448 (1): 111?4. doi : 10.1016/S0014-5793(99)00358-0 . PMID 10217420 .
Aldecoa A, Gujer R, Fischer JA, Born W (2000). "Mammalian calcitonin receptor-like receptor/receptor activity modifying protein complexes define calcitonin gene-related peptide and adrenomedullin receptors in Drosophila Schneider 2 cells". FEBS Lett . 471 (2?3): 156?60. doi : 10.1016/S0014-5793(00)01387-9 . PMID 10767413 .
Frayon S, Cueille C, Gnidehou S, et al. (2000). "Dexamethasone increases RAMP1 and CRLR mRNA expressions in human vascular smooth muscle cells". Biochem. Biophys. Res. Commun . 270 (3): 1063?7. doi : 10.1006/bbrc.2000.2552 . PMID 10772950 .
Kuwasako K, Shimekake Y, Masuda M, et al. (2000). "Visualization of the calcitonin receptor-like receptor and its receptor activity-modifying proteins during internalization and recycling". J. Biol. Chem . 275 (38): 29602?9. doi : 10.1074/jbc.M004534200 . PMID 10882736 .
Evans BN, Rosenblatt MI, Mnayer LO, et al. (2000). "CGRP-RCP, a novel protein required for signal transduction at calcitonin gene-related peptide and adrenomedullin receptors". J. Biol. Chem . 275 (40): 31438?43. doi : 10.1074/jbc.M005604200 . PMID 10903324 .
Hilairet S, Foord SM, Marshall FH, Bouvier M (2001). "Protein-protein interaction and not glycosylation determines the binding selectivity of heterodimers between the calcitonin receptor-like receptor and the receptor activity-modifying proteins". J. Biol. Chem . 276 (31): 29575?81. doi : 10.1074/jbc.M102722200 . PMID 11387328 .
Kamitani S, Sakata T (2001). "Glycosylation of human CRLR at Asn123 is required for ligand binding and signaling". Biochim. Biophys. Acta . 1539 (1?2): 131?9. doi : 10.1016/S0167-4889(01)00100-8 . PMID 11389975 .
Nikitenko LL, Brown NS, Smith DM, et al. (2001). "Differential and cell-specific expression of calcitonin receptor-like receptor and receptor activity modifying proteins in the human uterus". Mol. Hum. Reprod . 7 (7): 655?64. doi : 10.1093/molehr/7.7.655 . PMID 11420389 .
Hilairet S, Belanger C, Bertrand J, et al. (2001). "Agonist-promoted internalization of a ternary complex between calcitonin receptor-like receptor, receptor activity-modifying protein 1 (RAMP1), and beta-arrestin". J. Biol. Chem . 276 (45): 42182?90. doi : 10.1074/jbc.M107323200 . PMID 11535606 .
Aiyar N, Disa J, Pullen M, Nambi P (2002). "Receptor activity modifying proteins interaction with human and porcine calcitonin receptor-like receptor (CRLR) in HEK-293 cells". Mol. Cell. Biochem . 224 (1?2): 123?33. doi : 10.1023/A:1011907328682 . PMID 11693189 .
Hagner S, Haberberger RV, Overkamp D, et al. (2002). "Expression and distribution of calcitonin receptor-like receptor in human hairy skin". Peptides . 23 (1): 109?16. doi : 10.1016/S0196-9781(01)00586-1 . PMID 11814625 .
Hill H, Pioszak A (2013). "Bacterial expression and purification of a heterodimeric adrenomedullin receptor extracellular domain complex using DsbC-assisted disulfide shuffling" . Protein Expr Purif . 88 (1): 107?13. doi : 10.1016/j.pep.2012.11.019 . PMC 3568255 . PMID 23247088 .

????? ?? ????? [ ?????? ]

calcitonin receptor-like receptor ?? ??????????? ?????? ????? (MeSH) ?? ????????? ??? ????? ?????? ?????? ??????
???? ?? ?????? CALCRL ?? ?????? ????? UCSC.
?????? ?? ?????? CALCRL ?? ?????? ????? UCSC.

??? ?? ?????? ??? ?????????? ??????? ???. ????????? ?? ????? ?? ?? ????????? ??? ????.

[refGRCm38Ensembl-1] ??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000059588 - Ensembl , May 2017

[2] "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[3] "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[pmid8626685-4] Aiyar N, Rand K, Elshourbagy NA, Zeng Z, Adamou JE, Bergsma DJ, Li Y (May 1996). "A cDNA encoding the calcitonin gene-related peptide type 1 receptor". J. Biol. Chem . 271 (19): 11325?9. doi : 10.1074/jbc.271.19.11325 . PMID 8626685 .

[pmid23745702-5] Edvinsson L, Warfvinge K (2013). "CGRP receptor antagonism and migraine therapy". Current Protein & Peptide Science . 14 (5): 386?92. doi : 10.2174/13892037113149990055 . PMID 23745702 .

[6] ttps://medicalxpress.com/news/2018-05-germ-flesh-eating-disease-hijacks-neurons.html

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