BRAF

BRAF
????????? ?????
PDB	?????? ?????????????: PDBe RCSB
????? ????????? PDB
	1UWH , 1UWJ , 2FB8 , 2L05 , 3C4C , 3D4Q , 3IDP , 3II5 , 3NY5 , 3OG7 , 3PPJ , 3PPK , 3PRF , 3PRI , 3PSB , 3PSD , 3Q4C , 3Q96 , 3SKC , 3TV4 , 3TV6 , 4DBN , 4E26 , 4E4X , 4EHE , 4EHG , 4FC0 , 4FK3 , 4G9C , 4G9R , 4H58 , 4JVG , 4KSP , 4KSQ , 4MBJ , 4MNE , 4MNF , 4PP7 , 4WO5 , 5C9C , 5CT7 , 4XV2 , 4XV1 , 4XV9 , 4XV3 , 4R5Y , 5CSW , 5CSX , 4YHT , 5J2R , 5FD2 , 5HIE , 5HID , 5HI2 , 4CQE , 5J18
?????????????
??????? ????	BRAF , B-RAF1, BRAF1, NS7, RAFB1, B-Raf, B-Raf proto-oncogene, serine/threonine kinase
????????? ??????	OMIM: 164757 MGI: 88190 HomoloGene: 3197 GeneCards: BRAF
?????? ?? (???)
????????	???????? ? (???)
?????	39,702,397 bp
????? ????? RNA
	More reference expression data
?????????? ??
?????? ??????	? protein kinase activity ; ? calcium ion binding ; ? nucleotide binding ; ? transferase activity ; ? metal ion binding ; ? kinase activity ; ? protein serine/threonine kinase activity ; ? small GTPase binding ; ? GO:0001948? GO:0016582 ????? ???????? ; ? identical protein binding ; ? ATP binding ; ? MAP kinase kinase kinase activity ; ? mitogen-activated protein kinase kinase binding ; ? protein heterodimerization activity ;
??????? ?????	? intracellular membrane-bounded organelle ; ? membrane ; ? ???? ????? ; ? intracellular anatomical structure ; ? ????????? ; ? ??????? ; ? ????? ????? ; ? ????????? ; ? neuron projection ; ? cell body ;
?????? ?????	? cellular response to calcium ion ; ? GO:0007243 intracellular signal transduction ; ? ???????? ; ? establishment of protein localization to membrane ; ? negative regulation of apoptotic process ; ? positive regulation of peptidyl-serine phosphorylation ; ? protein phosphorylation ; ? animal organ morphogenesis ; ? GO:0072468 ???????? ???? ; ? negative regulation of signal transduction ; ? positive regulation of glucose transmembrane transport ; ? trehalose metabolism in response to stress ; ? MAPK cascade ; ? GO:1901313 positive regulation of gene expression ; ? ??????? ?????? ; ? positive regulation of ERK1 and ERK2 cascade ; ? myeloid progenitor cell differentiation ; ? ??????? ???? ; ? negative regulation of fibroblast migration ; ? thyroid gland development ; ? somatic stem cell population maintenance ; ? regulation of cell population proliferation ; ? CD4-positive, alpha-beta T cell differentiation ; ? positive T cell selection ; ? CD4-positive or CD8-positive, alpha-beta T cell lineage commitment ; ? response to peptide hormone ; ? GO:1904089 negative regulation of neuron apoptotic process ; ? regulation of T cell differentiation ; ? alpha-beta T cell differentiation ; ? thymus development ; ? regulation of axon regeneration ; ? positive regulation of axon regeneration ; ? positive regulation of axonogenesis ; ? T cell receptor signaling pathway ; ? protein heterooligomerization ; ? positive regulation of stress fiber assembly ; ? response to cAMP ; ? ????? ?????? ??? ; ? head morphogenesis ; ? face development ; ? positive regulation of substrate adhesion-dependent cell spreading ; ? cellular response to nerve growth factor stimulus ; ? negative regulation of synaptic vesicle exocytosis ; ? negative regulation of endothelial cell apoptotic process ;
	?????: ????? / ????????
?????????????
	673
	109880
	ENSG00000157764
	ENSMUSG00000002413
	P15056
	P28028
	XM_017012559? XR_001744857? XR_001744858? NM_001354609? NR_148928? NM_001374244? NM_001374258 NM_004333? XM_017012559? XR_001744857? XR_001744858? NM_001354609? NR_148928? NM_001374244? NM_001374258
	XM_006505353? XM_006505355? XM_006505358? XM_011241134? XM_011241135? XM_011241136? XM_011241137? XM_011241138? XM_011241139? XR_001785085? XR_001785086? XR_001785087? XM_030255094? XM_030255095? XM_036165746? XM_036165747? XM_036165748? XM_036165749? XM_036165750? XR_004942908? XR_004942909 NM_139294? XM_006505353? XM_006505355? XM_006505358? XM_011241134? XM_011241135? XM_011241136? XM_011241137? XM_011241138? XM_011241139? XR_001785085? XR_001785086? XR_001785087? XM_030255094? XM_030255095? XM_036165746? XM_036165747? XM_036165748? XM_036165749? XM_036165750? XR_004942908? XR_004942909
	XP_016868048? NP_001341538? NP_001361173? NP_001361187? NP_001365396? NP_001365397? NP_001365398? NP_001365399? NP_001365400? NP_001365401? NP_001365402? NP_001365403? NP_001365404 NP_004324? XP_016868048? NP_001341538? NP_001361173? NP_001361187? NP_001365396? NP_001365397? NP_001365398? NP_001365399? NP_001365400? NP_001365401? NP_001365402? NP_001365403? NP_001365404
	XP_006505416? XP_006505418? XP_006505421? XP_011239436? XP_011239437? XP_011239438? XP_011239439? XP_011239440? XP_011239441? XP_030110954? XP_030110955? XP_036021639? XP_036021640? XP_036021641? XP_036021642? XP_036021643 NP_647455? XP_006505416? XP_006505418? XP_006505421? XP_011239436? XP_011239437? XP_011239438? XP_011239439? XP_011239440? XP_011239441? XP_030110954? XP_030110955? XP_036021639? XP_036021640? XP_036021641? XP_036021642? XP_036021643
	?????????
??????/?????? ?????	??????/?????? ???

BRAF ??? ?? ?? ?? ????? ??? ?? ???????? ?? ??? ≪B-Raf≫ ?? ?? ????? ??? ??????. ??????? ???? ??? ?? ≪ ??????????? B-Raf ≫ ? ≪ ??????? B ?????? ?????? v-Raf ???????? ???????? ≫ ??? ??? ????? ???????? ?? ????? ?? ??? ???? ≪ ??????? ????? ??????? ????/??????? B-Raf ≫ ?????? ??????. ^[?]^[?]

??????? B-Raf ?? ???????? ???? ??????? ???? ? ????? ??? ????? ???? ???. ?? ??? ???? ?????? ???? ?? ?? ??? ?? ??? ???? ????? ??????. ^[?]

???? ??????? ?????? ?? BRAF ???? ??????? ???????? ???? ??????.

??????? B-Raf ????? ??? ???? ????? ??? ? ???? ??????? ????? ??????? ????/??????? ????? ??????.

????? [ ?????? ]

↑ ^??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000002413 - Ensembl , May 2017
↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ Sithanandam G, Kolch W, Duh FM, Rapp UR (December 1990). "Complete coding sequence of a human B-raf cDNA and detection of B-raf protein kinase with isozyme specific antibodies" . Oncogene . 5 (12): 1775?80. PMID 2284096 .
↑ Sithanandam G, Druck T, Cannizzaro LA, Leuzzi G, Huebner K, Rapp UR (April 1992). "B-raf and a B-raf pseudogene are located on 7q in man" . Oncogene . 7 (4): 795?9. PMID 1565476 .
↑ Davies H, Bignell GR, Cox C, Stephens P, Edkins S, Clegg S, Teague J, Woffendin H, Garnett MJ, Bottomley W, Davis N, Dicks E, Ewing R, Floyd Y, Gray K, Hall S, Hawes R, Hughes J, Kosmidou V, Menzies A, Mould C, Parker A, Stevens C, Watt S, Hooper S, Wilson R, Jayatilake H, Gusterson BA, Cooper C, Shipley J, Hargrave D, Pritchard-Jones K, Maitland N, Chenevix-Trench G, Riggins GJ, Bigner DD, Palmieri G, Cossu A, Flanagan A, Nicholson A, Ho JW, Leung SY, Yuen ST, Weber BL, Seigler HF, Darrow TL, Paterson H, Marais R, Marshall CJ, Wooster R, Stratton MR, Futreal PA (June 2002). "Mutations of the BRAF gene in human cancer". Nature . 417 (6892): 949?54. doi : 10.1038/nature00766 . PMID 12068308 .

?????????????? ?????????. ≪ BRAF (gene) ≫. ?? ????????? ?????????? ??????? ? ??????????? ?? ?? ?????? ????.

????? ??????? [ ?????? ]

Garnett MJ, Marais R (2004). "Guilty as charged: B-Raf is a human oncogene". Cancer Cell . 6 (4): 313?9. doi : 10.1016/j.ccr.2004.09.022 . PMID 15488754 .
Quiros RM, Ding HG, Gattuso P, Prinz RA, Xu X (2005). "Evidence that one subset of anaplastic thyroid carcinomas are derived from papillary carcinomas due to BRAF and p53 mutations". Cancer . 103 (11): 2261?8. doi : 10.1002/cncr.21073 . PMID 15880523 .
Karbowniczek M, Henske EP (2006). "The role of tuberin in cellular differentiation: are B-Raf and MAPK involved?". Ann N Y Acad Sci . 1059 (1): 168?73. Bibcode : 2005NYASA1059..168K . doi : 10.1196/annals.1339.045 . PMID 16382052 .
Ciampi R, Nikiforov YE (2007). "RET/PTC rearrangements and BRAF mutations in thyroid tumorigenesis". Endocrinology . 148 (3): 936?41. doi : 10.1210/en.2006-0921 . PMID 16946010 .
Espinosa AV, Porchia L, Ringel MD (2007). "Targeting BRAF in thyroid cancer" . British Journal of Cancer . 96 (1): 16?20. doi : 10.1038/sj.bjc.6603520 . PMC 2360215 . PMID 17179987 .

????? ?? ????? [ ?????? ]

???? ???? BRAF ?????? ? ????? ?????? ??? BRAF ?? ?????? ?????? ???? ??? ??????? ?????????? ????? ???? .

Allanson, Judith E; Roberts, Amy E (2011-08-04). Noonan Syndrome . NBK1124. In Pagon RA, Bird TD, Dolan CR, et al., eds. (1993?). GeneReviews™ [Internet] . Seattle WA: University of Washington, Seattle. {{ cite book }}: Check date values in: |year= ( help )
Rauen, Katherine A (2012-09-06). Cardiofaciocutaneous Syndrome . NBK1186. In ( GeneReviews )
Gelb, Bruce D; Tartaglia, Marco (2010-11-16). LEOPARD Syndrome . NBK1383. In ( GeneReviews )

"BRAF gene" . NCI Dictionary of Cancer Terms . Retrieved 2007-11-25 .

??? ?? ?????? ??? ?????????? ??????? ???. ????????? ?? ????? ?? ?? ????????? ??? ????.

[refGRCm38Ensembl-1] ??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000002413 - Ensembl , May 2017

[2] "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[3] "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[pmid_2284096-4] Sithanandam G, Kolch W, Duh FM, Rapp UR (December 1990). "Complete coding sequence of a human B-raf cDNA and detection of B-raf protein kinase with isozyme specific antibodies" . Oncogene . 5 (12): 1775?80. PMID 2284096 .

[pmid_1565476-5] Sithanandam G, Druck T, Cannizzaro LA, Leuzzi G, Huebner K, Rapp UR (April 1992). "B-raf and a B-raf pseudogene are located on 7q in man" . Oncogene . 7 (4): 795?9. PMID 1565476 .

[pmid12068308-6] Davies H, Bignell GR, Cox C, Stephens P, Edkins S, Clegg S, Teague J, Woffendin H, Garnett MJ, Bottomley W, Davis N, Dicks E, Ewing R, Floyd Y, Gray K, Hall S, Hawes R, Hughes J, Kosmidou V, Menzies A, Mould C, Parker A, Stevens C, Watt S, Hooper S, Wilson R, Jayatilake H, Gusterson BA, Cooper C, Shipley J, Hargrave D, Pritchard-Jones K, Maitland N, Chenevix-Trench G, Riggins GJ, Bigner DD, Palmieri G, Cossu A, Flanagan A, Nicholson A, Ho JW, Leung SY, Yuen ST, Weber BL, Seigler HF, Darrow TL, Paterson H, Marais R, Marshall CJ, Wooster R, Stratton MR, Futreal PA (June 2002). "Mutations of the BRAF gene in human cancer". Nature . 417 (6892): 949?54. doi : 10.1038/nature00766 . PMID 12068308 .

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??????	?????? ???? ?????? ????? ??????? ????????? Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme ??????? ???????? ??????? ?????
?????	?????????? Cooperativity ????????? ????? ?????????? ?????
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