AMFR

AMFR
????????? ?????
PDB	?????? ?????????????: PDBe RCSB
????? ????????? PDB
	2EJS , 2LVN , 2LVO , 2LVP , 2LVQ , 2LXH , 2LXP , 3FSH , 3H8K , 3TIW , 4G3O , 4LAD
?????????????
??????? ????	AMFR , GP78, RNF45, autocrine motility factor receptor
????????? ??????	OMIM: 603243 MGI: 1345634 HomoloGene: 888 GeneCards: AMFR
?????? ?? (???)
????????	???????? ? (???)
?????	94,739,470 bp
????? ????? RNA
	; ;
	More reference expression data
?????????? ??
?????? ??????	? protein-macromolecule adaptor activity ; ? chaperone binding ; ? GO:1904264? GO:1904822? GO:0090622? GO:0090302 ubiquitin protein ligase activity ; ? metal ion binding ; ? GO:0050372 ubiquitin-protein transferase activity ; ? ubiquitin-ubiquitin ligase activity ; ? GO:0001948? GO:0016582 ????? ???????? ; ? ubiquitin-specific protease binding ; ? transferase activity ; ? identical protein binding ; ? BAT3 complex binding ; ? signaling receptor activity ;
??????? ?????	? ????????? ; ? integral component of membrane ; ? membrane ; ? growth cone ; ? integral component of endoplasmic reticulum membrane ; ? neuronal cell body ; ? ?????? ; ? Derlin-1 retrotranslocation complex ; ? perinuclear region of cytoplasm ; ? ???? ????? ; ? ???? ?????????? ; ? endoplasmic reticulum membrane ; ? ?????? ???? ; ? endoplasmic reticulum quality control compartment ; ? GO:0009327 protein-containing complex ; ? ubiquitin ligase complex ; ? ??????? ;
?????? ?????	? ERAD pathway ; ? ubiquitin-dependent protein catabolic process ; ? GO:0010260 ???? ; ? protein polyubiquitination ; ? endoplasmic reticulum unfolded protein response ; ? protein K48-linked ubiquitination ; ? protein complex oligomerization ; ? protein ubiquitination ; ? ubiquitin-dependent ERAD pathway ; ? learning or memory ; ? positive regulation of protein binding ; ? GO:0072468 ???????? ???? ; ? protein autoubiquitination ; ? ?????? ??????? ; ? endoplasmic reticulum mannose trimming ;
	?????: ????? / ????????
?????????????
	267
	23802
	ENSG00000159461
	ENSMUSG00000031751
	Q9UKV5
	Q9R049
	NM_001144? NM_138958? NM_001323511? NM_001323512 XM_005255890? NM_001144? NM_138958? NM_001323511? NM_001323512
	XM_017312768 NM_011787? XM_017312768
	NP_001310440? NP_001310441? XP_005255947 NP_001135? NP_001310440? NP_001310441? XP_005255947
	XP_017168257 NP_035917? XP_017168257
	?????????
??????/?????? ?????	??????/?????? ???

??????? ???? ???? ???????? ??????? ? ( ??????? : Autocrine motility factor receptor, isoform 2 ) ?? ??????? ??? ?? ?? ????? ???? ?? ≪ AMFR ≫ ??????? ??????. ^[?]^[?]

???? ???? ??????? ?? ??????? ???????????? ??????? ????? ??? ?? ???? ???????? ????? ???? ?????? ? ?? ???? ?????????? ?????? ??? ????. ^[?] ??????? ??? ??????? ?????????? ?? ???? ????? ??? ?? ??????? p53 ???? ? ?? ??? ??? ????? ???? ???. ^[?]

???????? ?????? [ ?????? ]

????? [ ?????? ]

↑ ^??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000031751 - Ensembl , May 2017
↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ Watanabe H, Carmi P, Hogan V, Raz T, Silletti S, Nabi IR, Raz A (Aug 1991). "Purification of human tumor cell autocrine motility factor and molecular cloning of its receptor". J Biol Chem . 266 (20): 13442?8. PMID 1649192 .
↑ ^??? ^??? "Entrez Gene: AMFR autocrine motility factor receptor" .
↑ Watanabe H, Takehana K, Date M, Shinozaki T, Raz A (1 July 1996). "Tumor cell autocrine motility factor is the neuroleukin/phosphohexose isomerase polypeptide" . Cancer Res . 56 (13): 2960?3. PMID 8674049 .

?????????????? ?????????. ≪ AMFR ≫. ?? ????????? ?????????? ??????? ? ??????????? ?? ?? ????? ????.

????? ??????? [ ?????? ]

Huang B, Xie Y, Raz A (1995). "Identification of an upstream region that controls the transcription of the human autocrine motility factor receptor". Biochem. Biophys. Res. Commun . 212 (3): 727?42. doi : 10.1006/bbrc.1995.2031 . PMID 7626106 .
Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res . 6 (9): 807?28. doi : 10.1101/gr.6.9.807 . PMID 8889549 .
Shimizu K, Tani M, Watanabe H, et al. (1999). "The autocrine motility factor receptor gene encodes a novel type of seven transmembrane protein". FEBS Lett . 456 (2): 295?300. doi : 10.1016/S0014-5793(99)00966-7 . PMID 10456327 .
Fang S, Ferrone M, Yang C, et al. (2002). "The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum" . Proc. Natl. Acad. Sci. U.S.A . 98 (25): 14422?7. Bibcode : 2001PNAS...9814422F . doi : 10.1073/pnas.251401598 . PMC 64697 . PMID 11724934 .
Luo Y, Long JM, Lu C, et al. (2002). "A link between maze learning and hippocampal expression of neuroleukin and its receptor gp78". J. Neurochem . 80 (2): 354?61. doi : 10.1046/j.0022-3042.2001.00707.x . PMID 11902125 .
Timar J, Raso E, Dome B, et al. (2002). "Expression and function of the AMF receptor by human melanoma in experimental and clinical systems". Clin. Exp. Metastasis . 19 (3): 225?32. doi : 10.1023/A:1015595708241 . PMID 12067203 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899?903. Bibcode : 2002PNAS...9916899M . doi : 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Liang JS, Kim T, Fang S, et al. (2003). "Overexpression of the tumor autocrine motility factor receptor Gp78, a ubiquitin protein ligase, results in increased ubiquitinylation and decreased secretion of apolipoprotein B100 in HepG2 cells". J. Biol. Chem . 278 (26): 23984?8. doi : 10.1074/jbc.M302683200 . PMID 12670940 .
Takanami I, Takeuchi K (2003). "Autocrine motility factor-receptor gene expression in lung cancer". Jpn. J. Thorac. Cardiovasc. Surg . 51 (8): 368?73. doi : 10.1007/BF02719469 . PMID 12962414 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet . 36 (1): 40?5. doi : 10.1038/ng1285 . PMID 14702039 .
Registre M, Goetz JG, St Pierre P, et al. (2004). "The gene product of the gp78/AMFR ubiquitin E3 ligase cDNA is selectively recognized by the 3F3A antibody within a subdomain of the endoplasmic reticulum". Biochem. Biophys. Res. Commun . 320 (4): 1316?22. doi : 10.1016/j.bbrc.2004.06.089 . PMID 15303277 .
Zhong X, Shen Y, Ballar P, et al. (2004). "AAA ATPase p97/valosin-containing protein interacts with gp78, a ubiquitin ligase for endoplasmic reticulum-associated degradation". J. Biol. Chem . 279 (44): 45676?84. doi : 10.1074/jbc.M409034200 . PMID 15331598 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121?7. doi : 10.1101/gr.2596504 . PMC 528928 . PMID 15489334 .
Song BL, Sever N, DeBose-Boyd RA (2005). "Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase". Mol. Cell . 19 (6): 829?40. doi : 10.1016/j.molcel.2005.08.009 . PMID 16168377 .
Kaynak K, Kara M, Oz B, et al. (2006). "Autocrine motility factor receptor expression implies an unfavourable prognosis in resected stage I pulmonary adenocarcinomas". Acta Chir. Belg . 105 (4): 378?82. PMID 16184720 .
Ye Y, Shibata Y, Kikkert M, et al. (2006). "Inaugural Article: Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane" . Proc. Natl. Acad. Sci. U.S.A . 102 (40): 14132?8. Bibcode : 2005PNAS..10214132Y . doi : 10.1073/pnas.0505006102 . PMC 1242302 . PMID 16186510 .
Chen B, Mariano J, Tsai YC, et al. (2006). "The activity of a human endoplasmic reticulum-associated degradation E3, gp78, requires its Cue domain, RING finger, and an E2-binding site" . Proc. Natl. Acad. Sci. U.S.A . 103 (2): 341?6. Bibcode : 2006PNAS..103..341C . doi : 10.1073/pnas.0506618103 . PMC 1326157 . PMID 16407162 .
Haga A, Tanaka N, Funasaka T, et al. (2006). "The autocrine motility factor (AMF) and AMF-receptor combination needs sugar chain recognition ability and interaction using the C-terminal region of AMF". J. Mol. Biol . 358 (3): 741?53. doi : 10.1016/j.jmb.2006.02.046 . PMID 16563432 .
Shen Y, Ballar P, Fang S (2006). "Ubiquitin ligase gp78 increases solubility and facilitates degradation of the Z variant of alpha-1-antitrypsin". Biochem. Biophys. Res. Commun . 349 (4): 1285?93. doi : 10.1016/j.bbrc.2006.08.173 . PMID 16979136 .

????? ?? ????? [ ?????? ]

???? ???? AMFR ?????? ? ????? ?????? ??? AMFR ?? ?????? ?????? ???? ??? ??????? ?????????? ????? ???? .

??? ?? ?????? ??? ?????????? ??????? ???. ????????? ?? ????? ?? ?? ????????? ??? ????.

[refGRCm38Ensembl-1] ??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000031751 - Ensembl , May 2017

[2] "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[3] "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[pmid1649192-4] Watanabe H, Carmi P, Hogan V, Raz T, Silletti S, Nabi IR, Raz A (Aug 1991). "Purification of human tumor cell autocrine motility factor and molecular cloning of its receptor". J Biol Chem . 266 (20): 13442?8. PMID 1649192 .

[entrez-5] ??? ^??? "Entrez Gene: AMFR autocrine motility factor receptor" .

[6] Watanabe H, Takehana K, Date M, Shinozaki T, Raz A (1 July 1996). "Tumor cell autocrine motility factor is the neuroleukin/phosphohexose isomerase polypeptide" . Cancer Res . 56 (13): 2960?3. PMID 8674049 .

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