AMBP

AMBP
????????? ?????
PDB	?????? ?????????????: PDBe RCSB
????? ????????? PDB
	1BIK , 3QKG , 4ES7 , 4U30
?????????????
??????? ????	AMBP , A1M, EDC1, HCP, HI30, IATIL, ITI, ITIL, ITILC, UTI, alpha-1-microglobulin/bikunin precursor
????????? ??????	OMIM: 176870 MGI: 88002 HomoloGene: 1234 GeneCards: AMBP
?????? ?? (???)
????????	???????? ? (???)
?????	63,073,036 bp
????? ????? RNA
	More reference expression data
?????????? ??
?????? ??????	? peptidase inhibitor activity ; ? calcium channel inhibitor activity ; ? protein homodimerization activity ; ? calcium oxalate binding ; ? GO:0001948? GO:0016582 ????? ???????? ; ? heme binding ; ? serine-type endopeptidase inhibitor activity ; ? small molecule binding ; ? IgA binding ;
??????? ?????	? blood microparticle ; ? intracellular membrane-bounded organelle ; ? ????? ????? ; ? extracellular region ; ? cell surface ; ? extracellular exosome ; ? extracellular space ; ? GO:0005578 ????????? ????????????? ; ? collagen-containing extracellular matrix ;
?????? ?????	? negative regulation of peptidase activity ; ? female pregnancy ; ? receptor-mediated endocytosis ; ? negative regulation of JNK cascade ; ? ???? ????? ?? ; ? negative regulation of immune response ; ? ??????? ????? ; ? GO:0044257 protein catabolic process ; ? GO:0022415 viral process ; ? negative regulation of endopeptidase activity ;
	?????: ????? / ????????
?????????????
	259
	11699
	ENSG00000106927
	ENSMUSG00000028356
	P02760
	Q07456
	NM_001633
	NM_007443
	NP_001624
	NP_031469
	?????????
??????/?????? ?????	??????/?????? ???

???????????? ????-?/??????? ??????? (?? ??????? : Alpha-1-microglobulin/bikunin precursor ) ?? ?? ?????? ≪ AMBP ≫ ??? ???????? ??? ?? ?? ????? ???? ?? ≪ AMBP ≫ ??? ??????. ^[?]^[?]^[?]

??? ??????? ?? CD79A ?? ????? ???. ^[?]^[?]

???????? ?????? [ ?????? ]

????? [ ?????? ]

↑ ^??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000028356 - Ensembl , May 2017
↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ Vetr H, Gebhard W (Jun 1991). "Structure of the human alpha 1-microglobulin-bikunin gene". Biol. Chem. Hoppe-Seyler . 371 (12): 1185?96. doi : 10.1515/bchm3.1990.371.2.1185 . PMID 1708673 . {{ cite journal }}: Check date values in: |year= / |date= mismatch ( help )
↑ Salier JP, Simon D, Rouet P, Raguenez G, Muscatelli F, Gebhard W, Guenet JL, Mattei MG (Dec 1992). "Homologous chromosomal locations of the four genes for inter-alpha-inhibitor and pre-alpha-inhibitor family in human and mouse: assignment of the ancestral gene for the lipocalin superfamily". Genomics . 14 (1): 83?8. doi : 10.1016/S0888-7543(05)80287-3 . PMID 1385302 .
↑ "Entrez Gene: AMBP alpha-1-microglobulin/bikunin precursor" .
↑ Grubb AO, Lopez C, Tejler L, Mendez E (December 1983). "Isolation of human complex-forming glycoprotein, heterogeneous in charge (protein HC), and its IgA complex from plasma. Physiochemical and immunochemical properties, normal plasma concentration". J. Biol. Chem . 258 (23): 14698?707. PMID 6196366 .
↑ Berggard T, Thelin N, Falkenberg C, Enghild JJ, Akerstrom B (May 1997). "Prothrombin, albumin and immunoglobulin A form covalent complexes with alpha1-microglobulin in human plasma". Eur. J. Biochem . 245 (3): 676?83. doi : 10.1111/j.1432-1033.1997.00676.x . PMID 9183005 .

?????????????? ?????????. ≪ Alpha-1-microglobulin/bikunin precursor ≫. ?? ????????? ?????????? ??????? ? ??????????? ?? ?? ?????? ????.

????? ??????? [ ?????? ]

Akerstrom B, Logdberg L, Berggard T, Osmark P, Lindqvist A (2000). "alpha(1)-Microglobulin: a yellow-brown lipocalin". Biochim. Biophys. Acta . 1482 (1?2): 172?84. doi : 10.1016/S0167-4838(00)00157-6 . PMID 11058759 .
Kobayashi H, Suzuki M, Hirashima Y, Terao T (2003). "The protease inhibitor bikunin, a novel anti-metastatic agent" . Biol. Chem . 384 (5): 749?54. doi : 10.1515/BC.2003.083 . PMID 12817471 .
Ekstrom B, Berggard I (1977). "Human alpha1-microglobulin. Purification procedure, chemical and physiochemical properties". J. Biol. Chem . 252 (22): 8048?57. PMID 72071 .
Escribano J, Lopex-Otin C, Hjerpe A, Grubb A, Mendez E (1990). "Location and characterization of the three carbohydrate prosthetic groups of human protein HC". FEBS Lett . 266 (1?2): 167?70. doi : 10.1016/0014-5793(90)81531-R . PMID 1694784 .
Diarra-Mehrpour M, Bourguignon J, Sesboue R, Salier JP, Leveillard T, Martin JP (1990). "Structural analysis of the human inter-alpha-trypsin inhibitor light-chain gene". Eur. J. Biochem . 191 (1): 131?9. doi : 10.1111/j.1432-1033.1990.tb19102.x . PMID 1696200 .
Gebhard W, Schreitmuller T, Vetr H, Wachter E, Hochstrasser K (1990). "Complementary DNA and deduced amino acid sequences of procine alpha 1-microglobulin and bikunin". FEBS Lett . 269 (1): 32?6. doi : 10.1016/0014-5793(90)81112-2 . PMID 1696914 .
Falkenberg C, Grubb A, Akerstrom B (1990). "Isolation of rat serum alpha 1-microglobulin. Identification of a complex with alpha 1-inhibitor-3, a rat alpha 2-macroglobulin homologue". J. Biol. Chem . 265 (27): 16150?7. PMID 1697852 .
Nazimova SV, Akulenko IV, Za?tseva IV, Zara?ski? EI, Posiseeva LV (1990). "[Immunoenzyme analysis of placenta-specific alpha(1)-microglobulin in the blood serum in normal and pathological pregnancy]". Akush Ginekol (Mosk) (7): 70?2. PMID 1700638 .
Escribano J, Grubb A, Calero M, Mendez E (1991). "The protein HC chromophore is linked to the cysteine residue at position 34 of the polypeptide chain by a reduction-resistant bond and causes the charge heterogeneity of protein HC". J. Biol. Chem . 266 (24): 15758?63. PMID 1714898 .
Enghild JJ, Salvesen G, Hefta SA, Thøgersen IB, Rutherfurd S, Pizzo SV (1991). "Chondroitin 4-sulfate covalently cross-links the chains of the human blood protein pre-alpha-inhibitor". J. Biol. Chem . 266 (2): 747?51. PMID 1898736 .
Reisinger P, Hochstrasser K, Albrecht GJ, Lempart K, Salier JP (1985). "Human inter-alpha-trypsin inhibitor: localization of the Kunitz-type domains in the N-terminal part of the molecule and their release by a trypsin-like proteinase". Biol. Chem. Hoppe-Seyler . 366 (5): 479?83. doi : 10.1515/bchm3.1985.366.1.479 . PMID 2408638 .
Bourguignon J, Diarra-Mehrpour M, Sesboue R, Frain M, Sala-Trepat JM, Martin JP, Salier JP (1985). "Human inter-alpha-trypsin-inhibitor: characterization and partial nucleotide sequencing of a light chain-encoding cDNA". Biochem. Biophys. Res. Commun . 131 (3): 1146?53. doi : 10.1016/0006-291X(85)90210-4 . PMID 2413856 .
Mendez E, Fernandez-Luna JL, Grubb A, Leyva-Cobian F (1986). "Human protein HC and its IgA complex are inhibitors of neutrophil chemotaxis" . Proc. Natl. Acad. Sci. U.S.A . 83 (5): 1472?5. doi : 10.1073/pnas.83.5.1472 . PMC 323098 . PMID 2419908 .
Traboni C, Cortese R (1986). "Sequence of a full length cDNA coding for human protein HC (alpha 1 microglobulin)" . Nucleic Acids Res . 14 (15): 6340. doi : 10.1093/nar/14.15.6340 . PMC 311643 . PMID 2428011 .
Kaumeyer JF, Polazzi JO, Kotick MP (1986). "The mRNA for a proteinase inhibitor related to the HI-30 domain of inter-alpha-trypsin inhibitor also encodes alpha-1-microglobulin (protein HC)" . Nucleic Acids Res . 14 (20): 7839?50. doi : 10.1093/nar/14.20.7839 . PMC 311818 . PMID 2430261 .
Zara?ski? EI, Nazimova SV, Olefirenko GA, Pchelkina ZM, Petrunin DD, Tatarinov IuS, Fuks BB (1990). "[Immunoenzyme analysis of placenta-specific alpha 1-microglobulin in the serum of blood donors]". Vopr. Med. Khim . 35 (5): 130?2. PMID 2482577 .
Schreitmuller T, Hochstrasser K, Reisinger PW, Wachter E, Gebhard W (1987). "cDNA cloning of human inter-alpha-trypsin inhibitor discloses three different proteins". Biol. Chem. Hoppe-Seyler . 368 (8): 963?70. doi : 10.1515/bchm3.1987.368.2.963 . PMID 3663330 .
Morii M, Travis J (1985). "The reactive site of human inter-alpha-trypsin inhibitor is in the amino-terminal half of the protein". Biol. Chem. Hoppe-Seyler . 366 (1): 19?21. doi : 10.1515/bchm3.1985.366.1.19 . PMID 3890890 .

??? ?? ?????? ??? ?????????? ??????? ???. ????????? ?? ????? ?? ?? ????????? ??? ????.

[refGRCm38Ensembl-1] ??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000028356 - Ensembl , May 2017

[2] "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[3] "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[pmid1708673-4] Vetr H, Gebhard W (Jun 1991). "Structure of the human alpha 1-microglobulin-bikunin gene". Biol. Chem. Hoppe-Seyler . 371 (12): 1185?96. doi : 10.1515/bchm3.1990.371.2.1185 . PMID 1708673 . {{ cite journal }}: Check date values in: |year= / |date= mismatch ( help )

[pmid1385302-5] Salier JP, Simon D, Rouet P, Raguenez G, Muscatelli F, Gebhard W, Guenet JL, Mattei MG (Dec 1992). "Homologous chromosomal locations of the four genes for inter-alpha-inhibitor and pre-alpha-inhibitor family in human and mouse: assignment of the ancestral gene for the lipocalin superfamily". Genomics . 14 (1): 83?8. doi : 10.1016/S0888-7543(05)80287-3 . PMID 1385302 .

[entrez-6] "Entrez Gene: AMBP alpha-1-microglobulin/bikunin precursor" .

[pmid6196366-7] Grubb AO, Lopez C, Tejler L, Mendez E (December 1983). "Isolation of human complex-forming glycoprotein, heterogeneous in charge (protein HC), and its IgA complex from plasma. Physiochemical and immunochemical properties, normal plasma concentration". J. Biol. Chem . 258 (23): 14698?707. PMID 6196366 .

[pmid9183005-8] Berggard T, Thelin N, Falkenberg C, Enghild JJ, Akerstrom B (May 1997). "Prothrombin, albumin and immunoglobulin A form covalent complexes with alpha1-microglobulin in human plasma". Eur. J. Biochem . 245 (3): 676?83. doi : 10.1111/j.1432-1033.1997.00676.x . PMID 9183005 .

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