AKAP8

AKAP8
?????????????
??????? ????	AKAP8 , AKAP 95, AKAP-8, AKAP-95, AKAP95, A-kinase anchoring protein 8
????????? ??????	OMIM: 604692 MGI: 1928488 HomoloGene: 4278 GeneCards: AKAP8
?????? ?? (???)
????????	???????? ?? (???)
?????	32,540,212 bp
????? ????? RNA
	; ;
	More reference expression data
?????????? ??
?????? ??????	? metal ion binding ; ? DNA binding ; ? zinc ion binding ; ? double-stranded DNA binding ; ? protein kinase A regulatory subunit binding ; ? histone deacetylase binding ; ? DEAD/H-box RNA helicase binding ; ? GO:0001948? GO:0016582 ????? ???????? ; ? NF-kappaB binding ; ? RNA binding ;
??????? ?????	? ?????? ???? ; ? female pronucleus ; ? membrane ; ? condensed chromosome ; ? ???? ????? ; ? ????????? ; ? ??????????? ; ? ???? ; ? ??????? ???? ?? ; ? ????????? ;
?????? ?????	? positive regulation of histone deacetylation ; ? mitotic chromosome condensation ; ? GO:0072468 ???????? ???? ; ? cell cycle G2/M phase transition ; ? GO:0009373 regulation of transcription, DNA-templated ; ? immune system process ; ? cellular response to lipopolysaccharide ; ? cellular response to prostaglandin E stimulus ; ? transcription, DNA-templated ; ? protein transport ; ? negative regulation of tumor necrosis factor production ; ? ?????? ????? ???? ; ? GO:0007067 ?????? ; ? GO:0015915 transport ;
	?????: ????? / ????????
?????????????
	10270
	56399
	ENSG00000105127
	ENSMUSG00000024045
	O43823
	Q9DBR0
	NM_005858
	XM_006524663? XM_006524665? XM_006524666? NR_131218? NR_131219? NM_001357760 NM_019774? XM_006524663? XM_006524665? XM_006524666? NR_131218? NR_131219? NM_001357760
	NP_005849
	XP_006524726? XP_006524727? XP_006524728? XP_006524729? NP_001344689 NP_062748? XP_006524726? XP_006524727? XP_006524728? XP_006524729? NP_001344689
	?????????
??????/?????? ?????	??????/?????? ???

??????? ? ??????????? (??????????) ????? ? ( ??????? : A-kinase anchor protein 8 ) ?? ????? ??? ?? ?? ????? ???? ?? ≪ AKAP8 ≫ ???????? ??????. ^[?]^[?]

??? ?????? ?? ??? ?????? ??????? ????? ? ??????? ? ???? ????? ?????? ?? ?? ????? ?????? ?? ???? ???? ???? ?????. ??? ??????? ?? ????? ???????? ?? ???? ???? ???? ??? ? ????? ????? ????? ?? ???? ????? ????? ??????.

??? ?????? ?? MYCBP ? ^[?] ????? ???????-??????? ????.

????? [ ?????? ]

↑ ^??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000024045 - Ensembl , May 2017
↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ Eide T, Coghlan V, Orstavik S, Holsve C, Solberg R, Skalhegg BS, Lamb NJ, Langeberg L, Fernandez A, Scott JD, Jahnsen T, Tasken K (Mar 1998). "Molecular cloning, chromosomal localization, and cell cycle-dependent subcellular distribution of the A-kinase anchoring protein, AKAP95". Exp Cell Res . 238 (2): 305?16. doi : 10.1006/excr.1997.3855 . PMID 9473338 .
↑ "Entrez Gene: AKAP8 A kinase (PRKA) anchor protein 8" .
↑ Furusawa M, Taira T, Iguchi-Ariga SM, Ariga H (Dec 2002). "AMY-1 interacts with S-AKAP84 and AKAP95 in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex". J. Biol. Chem . 277 (52): 50885?92. doi : 10.1074/jbc.M206387200 . PMID 12414807 .

?????????????? ?????????. ≪ AKAP8 ≫. ?? ????????? ?????????? ??????? ? ??????????? ?? ? ????? ????.

???? ??????? ????? [ ?????? ]

Lester LB, Scott JD (1997). "Anchoring and scaffold proteins for kinases and phosphatases". Recent Prog. Horm. Res . 52 : 409?29, discussion 429?30. PMID 9238861 .
Michel JJ, Scott JD (2002). "AKAP mediated signal transduction" . Annu. Rev. Pharmacol. Toxicol . 42 : 235?57. doi : 10.1146/annurev.pharmtox.42.083101.135801 . PMID 11807172 .
Collas P, Le Guellec K, Tasken K (2000). "The A-kinase-anchoring protein AKAP95 is a multivalent protein with a key role in chromatin condensation at mitosis" . J. Cell Biol . 147 (6): 1167?80. doi : 10.1083/jcb.147.6.1167 . PMC 2168084 . PMID 10601332 .
Steen RL, Cubizolles F, Le Guellec K, Collas P (2000). "A kinase-anchoring protein (AKAP)95 recruits human chromosome-associated protein (hCAP)-D2/Eg7 for chromosome condensation in mitotic extract" . J. Cell Biol . 149 (3): 531?6. doi : 10.1083/jcb.149.3.531 . PMC 2174845 . PMID 10791967 .
Akileswaran L, Taraska JW, Sayer JA, et al. (2001). "A-kinase-anchoring protein AKAP95 is targeted to the nuclear matrix and associates with p68 RNA helicase". J. Biol. Chem . 276 (20): 17448?54. doi : 10.1074/jbc.M101171200 . PMID 11279182 .
Eide T, Carlson C, Tasken KA, et al. (2002). "Distinct but overlapping domains of AKAP95 are implicated in chromosome condensation and condensin targeting" . EMBO Rep . 3 (5): 426?32. doi : 10.1093/embo-reports/kvf089 . PMC 1084102 . PMID 11964380 .
Furusawa M, Taira T, Iguchi-Ariga SM, Ariga H (2003). "AMY-1 interacts with S-AKAP84 and AKAP95 in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex". J. Biol. Chem . 277 (52): 50885?92. doi : 10.1074/jbc.M206387200 . PMID 12414807 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899?903. doi : 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Eide T, Tasken KA, Carlson C, et al. (2003). "Protein kinase A-anchoring protein AKAP95 interacts with MCM2, a regulator of DNA replication". J. Biol. Chem . 278 (29): 26750?6. doi : 10.1074/jbc.M300765200 . PMID 12740381 .
Arsenijevic T, Degraef C, Dumont JE, et al. (2004). "A novel partner for D-type cyclins: protein kinase A-anchoring protein AKAP95" . Biochem. J . 378 (Pt 2): 673?9. doi : 10.1042/BJ20031765 . PMC 1223988 . PMID 14641107 .
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol . 6 (2): 97?105. doi : 10.1038/ncb1086 . PMID 14743216 .
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature . 428 (6982): 529?35. doi : 10.1038/nature02399 . PMID 15057824 .
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins" . Proc. Natl. Acad. Sci. U.S.A . 101 (33): 12130?5. doi : 10.1073/pnas.0404720101 . PMC 514446 . PMID 15302935 .
Kamada S, Kikkawa U, Tsujimoto Y, Hunter T (2005). "A-kinase-anchoring protein 95 functions as a potential carrier for the nuclear translocation of active caspase 3 through an enzyme-substrate-like association" . Mol. Cell. Biol . 25 (21): 9469?77. doi : 10.1128/MCB.25.21.9469-9477.2005 . PMC 1265837 . PMID 16227597 .
Beausoleil SA, Villen J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization" . Nat. Biotechnol . 24 (10): 1285?92. doi : 10.1038/nbt1240 . PMID 16964243 .
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell . 127 (3): 635?48. doi : 10.1016/j.cell.2006.09.026 . PMID 17081983 .

????? ?? ????? [ ?????? ]

???? ?? ?????? AKAP8 ?? ?????? ????? UCSC.
?????? ?? ?????? AKAP8 ?? ?????? ????? UCSC.

??? ?? ?????? ??? ?????????? ??????? ???. ????????? ?? ????? ?? ?? ????????? ??? ????.

[refGRCm38Ensembl-1] ??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000024045 - Ensembl , May 2017

[2] "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[3] "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[pmid9473338-4] Eide T, Coghlan V, Orstavik S, Holsve C, Solberg R, Skalhegg BS, Lamb NJ, Langeberg L, Fernandez A, Scott JD, Jahnsen T, Tasken K (Mar 1998). "Molecular cloning, chromosomal localization, and cell cycle-dependent subcellular distribution of the A-kinase anchoring protein, AKAP95". Exp Cell Res . 238 (2): 305?16. doi : 10.1006/excr.1997.3855 . PMID 9473338 .

[entrez-5] "Entrez Gene: AKAP8 A kinase (PRKA) anchor protein 8" .

[pmid12414807-6] Furusawa M, Taira T, Iguchi-Ariga SM, Ariga H (Dec 2002). "AMY-1 interacts with S-AKAP84 and AKAP95 in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex". J. Biol. Chem . 277 (52): 50885?92. doi : 10.1074/jbc.M206387200 . PMID 12414807 .

[?]

[?]

[?]

[?]

[?]

[?]