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Walter Jakob Gehring

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Walter Jakob Gehring
Walter Jakob Gehring (2014)
Born ( 1939-03-20 ) 20 March 1939
Zurich , Switzerland
Died 29 May 2014 (2014-05-29) (aged 75)
Basel , Switzerland
Known for Discovering the homeobox (DNA segment)
Awards Louis-Jeantet Prize for Medicine (1987) [1]
Scientific career
Fields Developmental Biologist
Institutions University of Zurich , Yale Medical School , Yale University , Biozentrum University of Basel

Walter Jakob Gehring (20 March 1939 [2] ? 29 May 2014 [3] ) [4] was a Swiss developmental biologist who was a professor at the Biozentrum Basel of the University of Basel , Switzerland. He obtained his PhD at the University of Zurich in 1965 and after two years as a research assistant of Ernst Hadorn he joined Alan Garen 's group at Yale University in New Haven as a postdoctoral fellow. [5]

In 1969 he was appointed associate professor at Yale Medical School [6] and 1972 returned to Switzerland to become a professor of developmental biology and genetics at the Biozentrum of the University of Basel. He was Secretary General of the European Molecular Biology Organization , [7] President of the International Society of Developmental Biologists , and Foreign Member of the national academies of the USA, Great Britain, [8] France, Germany and Sweden.

Gehring was mainly involved in studies of Drosophila genetics and development, particularly in the analysis of cell determination in the embryo and transdetermination of imaginal discs . He performed studies of the heat shock genes , various transposons , and the homeotic genes which are involved in the genetic control of development.

In 1983 Gehring and his collaborators ( William McGinnis , Michael S. Levine , Ernst Hafen, Richard Garber, Atsushi Kuroiwa, Johannes Wirz), discovered the homeobox , a DNA segment characteristic for homeotic genes which is not only present in arthropods and their ancestors, but also in vertebrates including man. [9]

Gehring was also involved in the development and application of enhancer trapping methods. He and his collaborators identified PAX6 as a master control gene for eye development, which led to a new theory about the monophyletic origin of the eyes in evolution. [10]

Awards [ edit ]

References [ edit ]

  1. ^ a b "Louis-Jeantet Prize, Year: 1987" .
  2. ^ Who, Marquis Who's (2008). Who's who in Science and Engineering . ISBN   9780837957685 .
  3. ^ Affolter, Markus; Muller, Martin (2014). "Walter Jakob Gehring (1939?2014)" . Developmental Cell . 30 (2): 120?122. doi : 10.1016/j.devcel.2014.07.011 . PMID   25215373 .
  4. ^ "Walter Jakob Gehring (1939?2014) | the Embryo Project Encyclopedia" .
  5. ^ Shearn, A; Rice, T; Garen, A; Gehring, W (1971). "Imaginal Disc Abnormalities in Lethal Mutants of Drosophila" . Proc. Natl. Acad. Sci. U.S.A . 68 (10): 2594?8. Bibcode : 1971PNAS...68.2594S . doi : 10.1073/pnas.68.10.2594 . PMC   389475 . PMID   5002822 .
  6. ^ "New Perspectives on Eye Development and the Evolution of Eyes and Photoreceptors" (PDF) . dbio.uevora.pt/ . Retrieved 3 June 2014 .
  7. ^ "EMBO & EMBC annual report 2001" (PDF) . embo.org/ . Retrieved 3 June 2014 .
  8. ^ Morata, Gines; Affolter, Markus (2021). "Walter Jakob Gehring. 20 March 1939?29 May 2014" . Biographical Memoirs of Fellows of the Royal Society . 71 : 197?212. doi : 10.1098/rsbm.2021.0011 . S2CID   236457532 .
  9. ^ Gehring, W. J.; Kuroiwa, A.; Hafen, E.; Levine, M. S.; McGinnis, W. (March 1984). "A conserved DNA sequence in homoeotic genes of the Drosophila Antennapedia and bithorax complexes". Nature . 308 (5958): 428?433. Bibcode : 1984Natur.308..428M . doi : 10.1038/308428a0 . PMID   6323992 . S2CID   4235713 .
  10. ^ Gehring, WJ; Ikeo, K (September 1999). "Pax 6: mastering eye morphogenesis and eye evolution". Trends Genet . 15 (9): 371?7. doi : 10.1016/s0168-9525(99)01776-x . PMID   10461206 .
  11. ^ "Otto-Warburg-Medal" . GBM . Retrieved 12 January 2014 .
  12. ^ White, P. C.; Mune, T.; Rogerson, F. M.; Kayes, K. M.; Agarwal, A. K. (1997). "March of Dimes Prize in Developmental Biology" . Pediatric Research . 41 (1): 25?9. doi : 10.1203/00006450-199704001-00014 . PMID   8979285 .
  13. ^ "The 2000 Kyoto Prize" . inamori-f.or.jp . Retrieved 3 June 2014 .
  14. ^ "Alfred Vogt-Stiftung zur Forderung der Augenheilkunde" . www.alfred-vogt-stiftung.ch .
  15. ^ "2002 Balzan Prize for Developmental Biology" . balzan.org . Retrieved 3 June 2014 .

Further reading [ edit ]

  • Walter, Niklaus (2002). "From Transdetermination to the Homeodomain at Atomic Resolution: An interview with Walter J. Gehring". Int. J. Dev. Biol . 46 (1): 29?37. PMID   11902685 .
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