Comprehensive review of research literature using systematic methods
A
systematic review
is a
scholarly synthesis
of the
evidence
on a clearly presented topic using critical methods to identify, define and assess research on the topic.
[1]
A systematic review extracts and interprets data from published studies on the topic (in the
scientific literature
), then analyzes, describes, critically appraises and summarizes interpretations into a refined evidence-based conclusion.
[1]
[2]
For example, a systematic review of
randomized controlled trials
is a way of summarizing and implementing
evidence-based medicine
.
[3]
While a systematic review may be applied in the
biomedical
or
health care
context, it may also be used where an assessment of a precisely defined subject can advance understanding in a field of research.
[4]
A systematic review may examine clinical tests,
public health
interventions, environmental interventions,
[5]
social interventions,
adverse effects
, qualitative evidence syntheses, methodological reviews, policy reviews, and
economic evaluations
.
[6]
[7]
Systematic reviews are closely related to
meta-analyses
, and often the same instance will combine both (being published with a subtitle of "a systematic review and meta-analysis"). The distinction between the two is that a meta-analysis uses
statistical
methods to
induce
a single number from the pooled
data set
(such as an
effect size
), whereas the strict definition of a systematic review excludes that step. However, in practice, when one is mentioned the other may often be involved, as it takes a systematic review to assemble the information that a meta-analysis analyzes, and people sometimes refer to an instance as a systematic review even if it includes the meta-analytical component.
An understanding of systematic reviews and how to implement them in practice is common for
professionals in health care
,
public health
, and
public policy
.
[1]
Systematic reviews contrast with a type of review often called a narrative review. Systematic reviews and narrative reviews both review the literature (the
scientific literature
), but the term
literature review
without further specification refers to a narrative review.
Characteristics
[
edit
]
A systematic review can be designed to provide a thorough summary of current literature relevant to a research question.
[1]
A systematic review uses a rigorous and transparent approach for research synthesis, with the aim of assessing and, where possible, minimizing bias in the findings. While many systematic reviews are based on an explicit quantitative meta-analysis of available data, there are also qualitative reviews and other types of mixed-methods reviews which adhere to standards for gathering, analyzing and reporting evidence.
[8]
Systematic reviews of
quantitative data
or mixed-method reviews sometimes use statistical techniques (meta-analysis) to combine results of eligible studies. Scoring levels are sometimes used to rate the quality of the evidence depending on the methodology used, although this is discouraged by the
Cochrane Library
.
[9]
As evidence rating can be subjective, multiple people may be consulted to resolve any scoring differences between how evidence is rated.
[10]
[11]
[12]
The
EPPI-Centre
,
Cochrane
, and the
Joanna Briggs Institute
have been influential in developing methods for combining both qualitative and quantitative research in systematic reviews.
[13]
[14]
[15]
Several reporting guidelines exist to standardise reporting about how systematic reviews are conducted. Such reporting guidelines are not quality assessment or appraisal tools. The
Preferred Reporting Items for Systematic Reviews and Meta-Analyses
(PRISMA) statement
[16]
suggests a standardized way to ensure a transparent and complete reporting of systematic reviews, and is now required for this kind of research by more than 170 medical journals worldwide.
[17]
Several specialized PRISMA guideline extensions have been developed to support particular types of studies or aspects of the review process, including PRISMA-P for review protocols and PRISMA-ScR for scoping reviews.
[17]
A list of PRISMA guideline extensions is hosted by the EQUATOR (Enhancing the QUAlity and Transparency Of health Research) Network.
[18]
However, the PRISMA guidelines have been found to be limited to intervention research and the guidelines have to be changed in order to fit non-intervention research. As a result, Non-Interventional, Reproducible, and Open (NIRO) Systematic Reviews was created to counter this limitation.
[19]
For qualitative reviews, reporting guidelines include ENTREQ (Enhancing transparency in reporting the synthesis of qualitative research) for qualitative evidence syntheses; RAMESES (Realist And MEta-narrative Evidence Syntheses: Evolving Standards) for meta-narrative and realist reviews;
[20]
[21]
and eMERGe (Improving reporting of Meta-Ethnography) for meta-
ethnograph
.
[13]
Developments in systematic reviews during the 21st century included realist reviews and the meta-narrative approach, both of which addressed problems of variation in methods and heterogeneity existing on some subjects.
[22]
[23]
Types
[
edit
]
There are over 30 types of systematic review and
Table 1
below non-exhaustingly summarises some of these.
[17]
[16]
There is not always consensus on the boundaries and distinctions between the approaches described below.
Table 1: A summary of some of the types of systematic review
Review type
|
Summary
|
Mapping review/systematic map
|
A mapping review maps existing literature and categorizes data. The method characterizes quantity and quality of literature, including by study design and other features. Mapping reviews can be used to identify the need for primary or secondary research.
[17]
|
Meta-analysis
|
A meta-analysis is a statistical analysis that combines the results of multiple quantitative studies. Using statistical methods, results are combined to provide evidence from multiple studies. The two types of data generally used for meta-analysis in health research are individual participant data and aggregate data (such as odds ratios or relative risks).
|
Mixed studies review/mixed methods review
|
Refers to any combination of methods where one significant stage is a literature review (often systematic). It can also refer to a combination of review approaches such as combining quantitative with qualitative research.
[17]
|
Qualitative systematic review/qualitative evidence synthesis
|
This method for integrates or compares findings from qualitative studies. The method can include 'coding' the data and looking for 'themes' or 'constructs' across studies. Multiple authors may improve the 'validity' of the data by potentially reducing individual bias.
[17]
|
Rapid review
|
An assessment of what is already known about a policy or practice issue, which uses systematic review methods to search for and critically appraise existing research. Rapid reviews are still a systematic review, however parts of the process may be simplified or omitted in order to increase rapidity.
[24]
Rapid reviews were used during the COVID-19 pandemic.
[25]
|
Systematic review
|
A systematic search for data, using a repeatable method. It includes appraising the data (for example the quality of the data) and a synthesis of research data.
|
Systematic search and review
|
Combines methods from a 'critical review' with a comprehensive search process. This review type is usually used to address broad questions to produce the most appropriate evidence synthesis. This method may or may not include quality assessment of data sources.
[17]
|
Systematized review
|
Include elements of systematic review process, but searching is often not as comprehensive as a systematic review and may not include quality assessments of data sources.
|
Scoping reviews
[
edit
]
Scoping reviews are distinct from systematic reviews in several ways. A scoping review is an attempt to search for concepts by
mapping
the language and data which surrounds those concepts and
adjusting the search method iteratively
to synthesize evidence and assess the scope of an area of inquiry.
[22]
[23]
This can mean that the
concept search
and method (including
data extraction
, organisation and analysis) are refined throughout the process, sometimes requiring deviations from any protocol or original research plan.
[26]
[27]
A scoping review may often be a preliminary stage before a systematic review, which 'scopes' out an area of inquiry and maps the language and key concepts to determine if a systematic review is possible or appropriate, or to lay the groundwork for a full systematic review. The goal can be to assess how much data or evidence is available regarding a certain area of interest.
[26]
[28]
This process is further complicated if it is
mapping
concepts across multiple languages or cultures.
As a scoping review should be systematically conducted and reported (with a transparent and repeatable method), some academic publishers categorize them as a kind of 'systematic review', which may cause confusion. Scoping reviews are helpful when it is not possible to carry out a systematic synthesis of research findings, for example, when there are no published clinical trials in the area of inquiry. Scoping reviews are helpful when determining if it is possible or appropriate to carry out a systematic review, and are a useful method when an area of inquiry is very broad,
[29]
for example, exploring how the public are involved in all stages systematic reviews.
[30]
There is still a lack of clarity when defining the exact method of a scoping review as it is both an
iterative process
and is still relatively new.
[31]
There have been several attempts to improve the standardisation of the method,
[27]
[26]
[28]
[32]
for example via a
Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)
guideline extension for scoping reviews (PRISMA-ScR).
[33]
PROSPERO
(the International Prospective Register of Systematic Reviews) does not permit the submission of protocols of scoping reviews,
[34]
although some journals will publish protocols for scoping reviews.
[30]
Stages
[
edit
]
While there are multiple kinds of systematic review methods, the main stages of a review can be summarised as follows:
Defining the research question
[
edit
]
Some reported that the 'best practices' involve 'defining an answerable question' and publishing the protocol of the review before initiating it to reduce the risk of unplanned research duplication and to enable transparency and consistency between methodology and protocol.
[35]
[36]
Clinical reviews of quantitative data are often structured using the mnemonic
PICO
, which stands for 'Population or Problem', 'Intervention or Exposure', 'Comparison', and 'Outcome', with other variations existing for other kinds of research. For qualitative reviews, PICo is 'Population or Problem', 'Interest', and 'Context'.
Searching for sources
[
edit
]
Relevant criteria can include selecting research that is of good quality and answers the defined question.
[35]
The search strategy should be designed to retrieve literature that matches the protocol's specified inclusion and exclusion criteria. The methodology section of a systematic review should list all of the databases and citation indices that were searched. The titles and abstracts of identified articles can be checked against predetermined criteria for eligibility and relevance. Each included study may be assigned an objective assessment of methodological quality, preferably by using methods conforming to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement,
[18]
or the standards of Cochrane.
[37]
Common information sources used in searches include scholarly databases of peer-reviewed articles such as
MEDLINE
,
Web of Science
,
Embase
, and
PubMed
, as well as sources of unpublished literature such as clinical trial registries and
grey literature
collections. Key references can also be yielded through additional methods such as citation searching, reference list checking (related to a search method called '
pearl growing
'), manually searching information sources not indexed in the major electronic databases (sometimes called 'hand-searching'),
[38]
and directly contacting experts in the field.
[39]
To be systematic, searchers must use a combination of search skills and tools such as database subject headings, keyword searching,
Boolean operators
, and proximity searching, while attempting to balance sensitivity (systematicity) and precision (accuracy). Inviting and involving an experienced information professional or librarian can improve the quality of systematic review search strategies and reporting.
[40]
[41]
[42]
[43]
[44]
Relevant data are 'extracted' from the data sources according to the review method. The data extraction method is specific to the kind of data, and data extracted on 'outcomes' is only relevant to certain types of reviews. For example, a systematic review of clinical trials might extract data about how the research was done (often called the method or 'intervention'), who participated in the research (including how many people), how it was paid for (for example, funding sources) and what happened (the outcomes).
[35]
Relevant data are being extracted and 'combined' in an intervention effect review, where a meta-analysis is possible.
[45]
Assess the eligibility of the data
[
edit
]
This stage involves assessing the eligibility of data for inclusion in the review, by judging it against criteria identified at the first stage.
[35]
This can include assessing if a data source meets the eligibility criteria, and recording why decisions about inclusion or exclusion in the review were made. Software can be used to support the selection process, including text mining tools and machine learning, which can automate aspects of the process.
[46]
The 'Systematic Review Toolbox' is a community driven, web-based catalogue of tools, to help reviewers chose appropriate tools for reviews.
[47]
Analyse and combine the data
[
edit
]
Analysing and combining data can provide an overall result from all the data. Because this combined result may use qualitative or quantitative data from all eligible sources of data, it is considered more reliable as it provides better evidence, as the more data included in reviews, the more confident we can be of conclusions. When appropriate, some systematic reviews include a meta-analysis, which uses statistical methods to combine data from multiple sources. A review might use quantitative data, or might employ a qualitative meta-synthesis, which synthesises data from qualitative studies. A review may also bring together the findings from quantitative and qualitative studies in a mixed methods or overarching synthesis.
[48]
The combination of data from a meta-analysis can sometimes be visualised. One method uses a
forest plot
(also called a
blobbogram
).
[35]
In an intervention effect review, the diamond in the 'forest plot' represents the combined results of all the data included.
[35]
An example of a 'forest plot' is the Cochrane Collaboration logo.
[35]
The logo is a forest plot of one of the first reviews which showed that corticosteroids given to women who are about to give birth prematurely can save the life of the newborn child.
[49]
Recent visualisation innovations include the albatross plot, which plots
p-values
against sample sizes, with approximate effect-size contours superimposed to facilitate analysis.
[50]
The contours can be used to infer effect sizes from studies that have been analysed and reported in diverse ways. Such visualisations may have advantages over other types when reviewing complex interventions.
Communication and dissemination
[
edit
]
Once these stages are complete, the review may be published, disseminated, and translated into practice after being adopted as evidence. The UK
National Institute for Health Research
(NIHR) defines dissemination as "getting the findings of research to the people who can make use of them to maximise the benefit of the research without delay".
[51]
Some users do not have time to invest in reading large and complex documents and/or may lack awareness or be unable to access newly published research. Researchers are therefore developing skills to use creative communication methods such as illustrations, blogs, infographics and board games to share the findings of systematic reviews.
[52]
Automation
[
edit
]
Living systematic reviews are a newer kind of semi-automated, up-to-date online summaries of research that are updated as new research becomes available.
[53]
The difference between a living systematic review and a conventional systematic review is the publication format. Living systematic reviews are "dynamic, persistent, online-only evidence summaries, which are updated rapidly and frequently".
[54]
The automation or semi-automation of the systematic process itself is increasingly being explored. While little evidence exists to demonstrate it is as accurate or involves less manual effort, efforts that promote training and using
artificial intelligence
for the process are increasing.
[55]
[53]
Research fields
[
edit
]
Health and medicine
[
edit
]
Current use of systematic reviews in medicine
[
edit
]
Many organisations around the world use systematic reviews, with the methodology depending on the guidelines being followed. Organisations which use systematic reviews in medicine and human health include the
National Institute for Health and Care Excellence
(NICE, UK), the
Agency for Healthcare Research and Quality
(AHRQ, US), and the
World Health Organization
. Most notable among international organisations is
Cochrane
, a group of over 37,000 specialists in healthcare who systematically review randomised trials of the effects of prevention, treatments, and rehabilitation as well as health systems interventions. They sometimes also include the results of other types of research. Cochrane Reviews are published in
The Cochrane Database of Systematic Reviews
section of the
Cochrane Library
. The 2015
impact factor
for
The Cochrane Database of Systematic Reviews
was 6.103, and it was ranked 12th in the Medicine, General & Internal category.
[56]
There are several types of systematic reviews, including:
[57]
[58]
[59]
[60]
- Intervention reviews
assess the benefits and harms of interventions used in healthcare and health policy.
- Diagnostic test accuracy reviews
assess how well a diagnostic test performs in diagnosing and detecting a particular disease. For conducting diagnostic test accuracy reviews, free software such as MetaDTA and CAST-HSROC in the graphical user interface is available.
[61]
[62]
- Methodology reviews
address issues relevant to how systematic reviews and clinical trials are conducted and reported.
- Qualitative reviews
synthesize qualitative evidence to address questions on aspects other than effectiveness.
- Prognosis reviews
address the probable course or future outcome(s) of people with a health problem.
- Overviews of Systematic Reviews
(
OoRs
) compile multiple pieces of evidence from systematic reviews into a single accessible document, sometimes referred to as
umbrella reviews
.
- Living systematic reviews
are continually updated, incorporating relevant new evidence as it becomes available.
[63]
- Rapid reviews
are a form of knowledge synthesis that "accelerates the process of conducting a traditional systematic review through streamlining or omitting specific methods to produce evidence for stakeholders in a resource-efficient manner".
[64]
- Reviews of complex health interventions in complex systems
are to improve evidence synthesis and guideline development.
[65]
Patient and public involvement in systematic reviews
[
edit
]
There are various ways patients and the public can be involved in producing systematic reviews and other outputs. Tasks for public members can be organised as 'entry level' or higher. Tasks include:
- Joining a collaborative volunteer effort to help categorise and summarise healthcare evidence
[66]
- Data extraction and risk of bias assessment
- Translation of reviews into other languages
A systematic review of how people were involved in systematic reviews aimed to document the evidence-base relating to stakeholder involvement in systematic reviews and to use this evidence to describe how stakeholders have been involved in systematic reviews.
[67]
Thirty percent involved patients and/or carers. The ACTIVE framework provides a way to describe how people are involved in systematic review and may be used as a way to support systematic review authors in planning people's involvement.
[68]
Standardised Data on Initiatives (STARDIT) is another proposed way of reporting who has been involved in which tasks during research, including systematic reviews.
[69]
[70]
There has been some criticism of how Cochrane prioritises systematic reviews.
[71]
Cochrane has a project that involved people in helping identify research priorities to inform Cochrane Reviews.
[72]
[73]
In 2014, the
Cochrane?Wikipedia
partnership was formalised.
[74]
Environmental health and toxicology
[
edit
]
Systematic reviews are a relatively recent innovation in the field of
environmental health
and
toxicology
. Although mooted in the mid-2000s, the first full frameworks for conduct of systematic reviews of environmental health evidence were published in 2014 by the US
National Toxicology Program
's Office of Health Assessment and Translation
[75]
and the Navigation Guide at the University of California San Francisco's Program on Reproductive Health and the Environment.
[76]
Uptake has since been rapid, with the estimated number of systematic reviews in the field doubling since 2016 and the first consensus recommendations on best practice, as a precursor to a more general standard, being published in 2020.
[77]
Social, behavioural, and educational
[
edit
]
In 1959, social scientist and social work educator
Barbara Wootton
published one of the first contemporary systematic reviews of literature on anti-social behavior as part of her work,
Social Science and Social Pathology
.
[78]
[79]
Several organisations use systematic reviews in social, behavioural, and educational areas of evidence-based policy, including the
National Institute for Health and Care Excellence
(NICE, UK),
Social Care Institute for Excellence
(SCIE, UK), the
Agency for Healthcare Research and Quality
(AHRQ, US), the
World Health Organization
, the International Initiative for Impact Evaluation (3ie), the
Joanna Briggs Institute
, and the
Campbell Collaboration
. The quasi-standard for systematic review in the social sciences is based on the procedures proposed by the Campbell Collaboration, which is one of several groups promoting
evidence-based policy
in the
social sciences
.
[80]
Others
[
edit
]
Some attempts to transfer the procedures from medicine to business research have been made,
[81]
including a step-by-step approach,
[82]
[83]
and developing a standard procedure for conducting systematic literature reviews in business and economics.
Systematic reviews are increasingly prevalent in other fields, such as international development research.
[84]
Subsequently, several donors (including the UK
Department for International Development
(DFID) and
AusAid
) are focusing more on testing the appropriateness of systematic reviews in assessing the impacts of development and
humanitarian interventions
.
[84]
The Collaboration for Environmental Evidence (CEE) has a journal titled
Environmental Evidence
, which publishes systematic reviews, review protocols, and systematic maps on the impacts of human activity and the effectiveness of management interventions.
[85]
Review tools
[
edit
]
A 2022 publication identified 24 systematic review tools and ranked them by inclusion of 30 features deemed most important when performing a systematic review in accordance with best practices. The top six software tools (with at least 21/30 key features) are all proprietary paid platforms, typically web-based, and include:
[86]
- Giotto Compliance
- DistillerSR
- Nested Knowledge
- EPPI-Reviewer Web
- LitStream
- JBI SUMARI
The Cochrane Collaboration provides a handbook for systematic reviewers of interventions which "provides guidance to authors for the preparation of Cochrane Intervention reviews."
[37]
The
Cochrane Handbook
also outlines steps for preparing a systematic review
[37]
and forms the basis of two sets of standards for the conduct and reporting of Cochrane Intervention Reviews (MECIR; Methodological Expectations of Cochrane Intervention Reviews).
[87]
It also contains guidance on integrating patient-reported outcomes into reviews.
Limitations
[
edit
]
Out-dated or risk of bias
[
edit
]
While systematic reviews are regarded as the strongest form of evidence, a 2003 review of 300 studies found that not all systematic reviews were equally reliable, and that their reporting can be improved by a universally agreed upon set of standards and guidelines.
[88]
A further study by the same group found that of 100 systematic reviews monitored, 7% needed updating at the time of publication, another 4% within a year, and another 11% within 2 years; this figure was higher in rapidly changing fields of medicine, especially cardiovascular medicine.
[89]
A 2003 study suggested that extending searches beyond major databases, perhaps into
grey literature
, would increase the effectiveness of reviews.
[90]
Some authors have highlighted problems with systematic reviews, particularly those conducted by
Cochrane
, noting that published reviews are often biased, out of date, and excessively long.
[91]
Cochrane reviews have been criticized as not being sufficiently critical in the selection of trials and including too many of low quality. They proposed several solutions, including limiting studies in meta-analyses and reviews to
registered clinical trials
, requiring that original data be made available for statistical checking, paying greater attention to sample size estimates, and eliminating dependence on only published data. Some of these difficulties were noted as early as 1994:
much poor research arises because researchers feel compelled for career reasons to carry out research that they are ill-equipped to perform, and nobody stops them.
Methodological limitations of meta-analysis have also been noted.
[93]
Another concern is that the methods used to conduct a systematic review are sometimes changed once researchers see the available trials they are going to include.
[94]
Some websites have described retractions of systematic reviews and published reports of studies included in published systematic reviews.
[95]
[96]
[97]
Eligibility criteria that is arbitrary may affect the perceived quality of the review.
[98]
[99]
Limited reporting of data from human studies
[
edit
]
The
AllTrials
campaign report that around half of clinical trials have never reported results and works to improve reporting.
[100]
'Positive' trials were twice as likely to be published as those with 'negative' results.
[101]
As of 2016, it is legal for-profit companies to conduct clinical trials and not publish the results.
[102]
For example, in the past 10 years, 8.7 million patients have taken part in trials that have not published results.
[102]
These factors mean that it is likely there is a significant publication bias, with only 'positive' or perceived favourable results being published. A recent systematic review of industry sponsorship and research outcomes concluded that "sponsorship of drug and device studies by the manufacturing company leads to more favorable efficacy results and conclusions than sponsorship by other sources" and that the existence of an industry bias that cannot be explained by standard 'risk of bias' assessments.
[103]
Poor compliance with review reporting guidelines
[
edit
]
The rapid growth of systematic reviews in recent years has been accompanied by the attendant issue of poor compliance with guidelines, particularly in areas such as declaration of registered study protocols, funding source declaration, risk of bias data, issues resulting from data abstraction, and description of clear study objectives.
[104]
[105]
[106]
[107]
[108]
A host of studies have identified weaknesses in the rigour and reproducibility of search strategies in systematic reviews.
[109]
[110]
[111]
[112]
[113]
[114]
To remedy this issue, a new PRISMA guideline extension called PRISMA-S is being developed.
[115]
Furthermore, tools and checklists for peer-reviewing search strategies have been created, such as the Peer Review of Electronic Search Strategies (PRESS) guidelines.
[116]
A key challenge for using systematic reviews in clinical practice and healthcare policy is assessing the quality of a given review. Consequently, a range of appraisal tools to evaluate systematic reviews have been designed. The two most popular measurement instruments and scoring tools for systematic review quality assessment are AMSTAR 2 (a measurement tool to assess the methodological quality of systematic reviews)
[117]
[118]
[119]
and ROBIS (Risk Of Bias In Systematic reviews); however, these are not appropriate for all systematic review types.
[120]
History
[
edit
]
The first publication that is now recognized as equivalent to a modern systematic review was a 1753 paper by
James Lind
, which reviewed all of the previous publications about
scurvy
.
[121]
Systematic reviews appeared only sporadically until the 1980s, and became common after 2000.
[121]
More than 10,000 systematic reviews are published each year.
[121]
History in medicine
[
edit
]
A 1904
British Medical Journal
paper by
Karl Pearson
collated data from several studies in the UK, India and South Africa of
typhoid inoculation
. He used a meta-analytic approach to aggregate the outcomes of multiple clinical studies.
[122]
In 1972, Archie Cochrane wrote: "It is surely a great criticism of our profession that we have not organised a critical summary, by specialty or subspecialty, adapted periodically, of all relevant randomised controlled trials".
[123]
Critical appraisal and synthesis of research findings in a systematic way emerged in 1975 under the term 'meta analysis'.
[124]
[125]
Early syntheses were conducted in broad areas of public policy and social interventions, with systematic research synthesis applied to medicine and health.
[126]
Inspired by his own personal experiences as a senior medical officer in prisoner of war camps,
Archie Cochrane
worked to improve the scientific method in medical evidence.
[127]
His call for the increased use of randomised controlled trials and systematic reviews led to the creation of The Cochrane Collaboration,
[128]
which was founded in 1993 and named after him, building on the work by
Iain Chalmers
and colleagues in the area of pregnancy and childbirth.
[129]
[123]
See also
[
edit
]
References
[
edit
]
This article was submitted to
WikiJournal of Medicine
for external
academic peer review
in 2019 (
reviewer reports
). The updated content was reintegrated into the Wikipedia page under a
CC-BY-SA-3.0
license (
2020
). The version of record as reviewed is:
Jack Nunn; Steven Chang; et al. (9 November 2020).
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.
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