From Wikipedia, the free encyclopedia
Author and cancer biologist
Stuart A. Aaronson
(born February 28, 1942) is an American
author
and
cancer
biologist
.
[1]
[2]
He has authored more than 500 publications and holds over 50 patents, and was the Jane B. and Jack R. Aron Professor of Neoplastic Diseases and Chairman of Oncological Sciences at
The Mount Sinai Hospital
in
New York City
until March 2013, when he assumed the title of Founding Chair Emeritus of the Department of Oncological Sciences.
[3]
The current Chairman of Oncological Sciences is Ramon E. Parsons.
Biography
[
edit
]
Aaronson graduated summa cum laude from the
University of California, Berkeley
, in 1962, with a degree in
chemistry
. He earned his M.D. from the
University of California, San Francisco Medical Center
in 1966, and completed a fellowship at the
University of Cambridge
in
England
and an internship in medicine at Moffitt Hospital in
San Francisco
.
[3]
In 1967, Aaronson joined the
National Institutes of Health
as a Senior Staff Fellow. He headed the Molecular Biology Section of the Viral Carcinogenesis Branch from 1970 until 1977, after which he became Chief of the Laboratory of Cellular and Molecular Biology at the
National Cancer Institute
, until 1993, when he was named Chairman of Oncological Sciences at The Mount Sinai Hospital.
Research
[
edit
]
Aaronson's early research established the transformation-competent but replication-defective nature of mammalian
sarcoma
viruses and molecularly cloned many of their
oncogenes
.
[3]
[4]
His investigations of the v-sis oncogene established the first normal function of an oncogene and its role in growth factor signaling.
[1]
[2]
His discovery of
erbB2
as a v-erbB-related gene amplified in a human breast carcinoma and the demonstration of its transforming properties paved the way for targeted therapies directed against its product,
[4]
and his successful isolation of
KGF
(FGF7), a growth factor present in the epithelialization-phase of wound healing, led to
Amgen
's successful phase III
clinical trial
and
FDA
approval of KGF for treatment of
mucositis
.
[5]
[6]
Current research includes investigations into the mechanisms by which tumor suppressor genes induce permanent growth arrest/
senescence
, the signaling pathways involved, and investigations of the autocrine and paracrine acting growth factors
PDGF
, KGF,
HGF
, and
Wnt
ligands.
[3]
To date, three papers on which Aaronson is author have been retracted, and two papers which he authored have received expressions of concern.
[7]
Awards and honors
[
edit
]
- 1982 Rhoads Memorial Award
- 1982 PHS Meritorious Service Medal
- 1989 Paul Ehrlich Award
- 1989 PHS Distinguished Service Medal
- 1990 Milken Award
- 1991 Chirone Prize
- 1991 Harvey Lecture
- 1991 Wadsworth Memorial Foundation Award
- 2005 FLC Mid-Atlantic Regional Excellence in Technology Transfer Award ? Kepivance
- 2006 National FLC Award for Excellence in Technology Transfer ? Kepivance: Improving the Quality of Life for Cancer Patients
Patents
[
edit
]
Partial list:
Patent Number
|
Title
|
6479255
[8]
|
Polynucleotides encoding human FRP and fragments thereof
|
6225088
[9]
|
DNA encoding plasminogen-like growth factor (PLGF) and related embodiments
|
6228600
[10]
|
Immunoassays for the alpha platelet-derived growth factor receptor
|
6403769
[11]
|
Fusion proteins that include antibody and nonantibody portions
|
6566098
[12]
|
DNA encoding truncated hepatocyte growth factor variants
|
6639060
[13]
|
erbB-3 nucleic acids
|
6653084
[14]
|
Anti-erbB-2 antibodies to human receptor related to but distinct from EGF receptor
|
6660488
[15]
|
Antibodies for the alpha platelet-derived growth factor receptor
|
6709842
[16]
|
DNA encoding a growth factor specific for epithelial cells
|
6833132
[17]
|
Method of stimulating epithelial cells using keratinocyte growth factor (KGF) and method of inhibiting KGF activity
|
Publications
[
edit
]
Partial list:
- Asciutti S, Akiri G, Grumolato L, Vijayakumar S, Aaronson S (2011).
"Diverse mechanisms of Wnt activation and effects of pathway inhibition on proliferation of human gastric carcinoma cells"
.
Oncogene
.
30
(8): 956?966.
doi
:
10.1038/onc.2010.475
.
PMC
3965355
.
PMID
21042278
.
- Akiri G, Cherian M, Vijayakumar S, Liu G, Bafico A, Aaronson S (2009).
"Wnt pathway aberrations including autocrine Wnt activation occur at high frequency in human non-small-cell lung carcinoma"
.
Oncogene
.
28
(21): 2163?2172.
doi
:
10.1038/onc.2009.82
.
PMC
4451819
.
PMID
19377513
.
- Liu G, Grumolato L, Arroyave R, Qiao H, Akiri G, Aaronson S (April 2009).
"Canonical Wnts function as potent regulators of osteogenesis by human mesenchymal stem cells"
.
Journal of Cell Biology
.
185
(1): 67?75.
doi
:
10.1083/jcb.200810137
.
PMC
2700509
.
PMID
19349579
.
- Zhao B, Benson E, Qiao R, Wang X, Kim S, Manfredi J, Lee S, Aaronson S (2009).
"Cellular senescence and organismal ageing in the absence of p21 CIP1/WAF1 in ku80-/-mice"
.
The EMBO Journal
.
10
(1): 71?78.
doi
:
10.1038/embor.2008.220
.
PMC
2613205
.
PMID
19079133
.
- Ongusaha PP, Qi HH, Raj L, Kim YB, Aaronson SA, Davis R, Shi Y, Liao J, Lee SW (2008).
"Identification of ROCK1 as an Upstream Activator of the JIP-3 to JNK Signaling Axis in Response to UVB Damage"
.
Sci Signal
.
1
(47): 14.
doi
:
10.1126/scisignal.1161938
.
PMC
2649725
.
PMID
19036714
.
- Munoz-Fontella C, Macip S, Martinez-Sobrido L, Brown L, Ashour J, Garcia-Sastre A, Lee SW, Aaronson SA (2008).
"Transcriptional role of p53 in Interferon-mediated antiviral immunity"
(PDF)
.
Journal of Experimental Medicine
.
205
(8): 1?10.
doi
:
10.1084/jem.20080383
.
PMC
2525597
.
PMID
18663127
.
- Mahale A, Khan Z, Igarashi M, Nanjangud G, Qiao RF, Yao S, Lee SW, Aaronson SA (2008).
"Clonal Selection in Malignant Transformation of Human Fibroblasts Transduces with Defined Cellular Oncogenes"
.
Cancer Research
.
68
(5): 1417?1426.
doi
:
10.1158/0008-5472.CAN-07-3021
.
PMID
18316605
.
- Brown L, Ongusaha P, Kim H, Nuti S, Mandinova A, Lee J, Khosravi-Far R, Aaronson SA, Lee S, et al. (2007).
"CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner"
.
The EMBO Journal
.
26
(14): 3410?3422.
doi
:
10.1038/sj.emboj.7601779
.
PMC
1933410
.
PMID
17599062
.
- Das S, Raj L, Zhao B, Bernstein A, Aaronson SA, Lee SA (2007).
"Hzf, a key modulator of p53 mediated transcription, functions as a critical determinant of cell survival and death upon genotoxic stress"
.
Cell
.
130
(4): 624?637.
doi
:
10.1016/j.cell.2007.06.013
.
PMC
2779720
.
PMID
17719541
.
References
[
edit
]
- ^
a
b
"ACGT - Scientific Advisory Council - Stuart A. Aaronson, M.D."
Archived from
the original
on June 5, 2013
. Retrieved
2010-01-06
.
- ^
a
b
"Breast Cancer Research Foundation: Stuart Aaronson"
. Archived from
the original
on June 20, 2010
. Retrieved
2010-01-06
.
- ^
a
b
c
d
"The Mount Sinai Hospital - Faculty profile"
. Retrieved
2010-01-06
.
- ^
a
b
"The Black Family Stem Cell Institute"
. Retrieved
2010-01-06
.
- ^
"Human Keratinocyte Growth Factor (KGF) from GenWay Biotech, Inc"
.
Biocompare
. Retrieved
2010-01-06
.
- ^
Ulich, T. R.; Yi, E. S.; Cardiff, R.; Yin, S.; Bikhazi, N.; Biltz, R.; Morris, C. F.; Pierce, G. F. (May 1994).
"Keratinocyte growth factor is a growth factor for mammary epithelium in vivo. The mammary epithelium of lactating rats is resistant to the proliferative action of keratinocyte growth factor"
.
The American Journal of Pathology
.
144
(5): 862?868.
PMC
1887355
.
PMID
8178937
.
- ^
"Retraction Watch Database"
.
- ^
"United States Patent: 6479255"
.
- ^
"United States Patent: 6225088"
.
- ^
"United States Patent: 6228600"
.
- ^
"United States Patent: 6403769"
.
- ^
"United States Patent: 6566098"
.
- ^
"United States Patent: 6639060"
.
- ^
"United States Patent: 6653084"
.
- ^
"United States Patent: 6660488"
.
- ^
"United States Patent: 6709842"
.
- ^
"United States Patent: 6833132"
.
External links
[
edit
]
- The Mount Sinai Hospital homepage
- Icahn School of Medicine at Mount Sinai homepage
- Activation of a Cancer Gene by Single Mutation Reported.
The New York Times
, September 28, 1983
- Cancer Gene Linked to Flaws in Growth of an Ordinary Cell.
The New York Times, February 10, 1984
- The Long Road: Scientists worked for years to unravel Met's role in cancer.
Cover story,
Chemical & Engineering News
, August 20, 2007
- Ongusaha, Pat P; Kim, Hyung-Gu; Boswell, Sarah A; Ridley, Anne J; Der, Channing J; Dotto, G. Paolo; Kim, Young-Bum; Aaronson, Stuart A; Lee, Sam W (2012).
"RhoE is a Pro-Survival p53 Target Gene that Inhibits ROCK I-Mediated Apoptosis in Response to Genotoxic Stress"
.
Current Biology
.
22
(22): 2466?2472.
Bibcode
:
2012CBio...22.2186O
.
doi
:
10.1016/j.cub.2012.11.007
.
- https://web.archive.org/web/20120909024225/http://www.science-fraud.org/?tag=sw-lee
- Ide, Takao; Brown-Endres, Lauren; Chu, Kiki; Ongusaha, Pat P.; Ohtsuka, Takao; El-Deiry, Wafik S.; Aaronson, Stuart A.; Lee, Sam W. (August 2013).
"Retraction Notice to: GAMT, a p53-Inducible Modulator of Apoptosis, Is Critical for the Adaptive Response to Nutrient Stress"
.
Molecular Cell
.
51
(4): 552.
doi
:
10.1016/j.molcel.2013.08.005
.
PMC
3814217
.
PMID
24137726
.
- Ide, Takao; Brown-Endres, Lauren; Chu, Kiki; Ongusaha, Pat P; Ohtsuka, Takao; El-Deiry, Wafik S; Aaronson, Stuart A; Lee, Sam W (2013).
"Retraction Notice to: GAMT, a p53-Inducible Modulator of Apoptosis, is Critical for the Adaptive Response to Nutrient Stress"
.
Molecular Cell
.
51
(4): 552.
doi
:
10.1016/j.molcel.2013.08.005
.
PMC
3814217
.
PMID
24137726
.
- Ongusaha, Pat P.; Kim, Hyung-Gu; Boswell, Sarah A.; Ridley, Anne J.; Der, Channing J.; Dotto, G. Paolo; Kim, Young-Bum; Aaronson, Stuart A.; Lee, Sam W. (17 June 2019).
"Retraction Notice to: RhoE Is a Pro-Survival p53 Target Gene that Inhibits ROCK I-Mediated Apoptosis in Response to Genotoxic Stress"
.
Current Biology
.
29
(12): 2107.
Bibcode
:
2019CBio...29.2107O
.
doi
:
10.1016/j.cub.2019.05.065
.
PMC
6644033
.
PMID
31211968
.
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