Steve David Macleod Brown
FRS
FMedSci
[9]
[1]
is director of the
Medical Research Council (MRC)
Mammalian Genetics Unit, MRC Harwell at
Harwell Science and Innovation Campus
, Oxfordshire,
[9]
[10]
[11]
[12]
[13]
a research centre on mouse genetics. In addition, he leads the Genetics and Pathobiology of Deafness research group.
[14]
Education
[
edit
]
Brown was educated at
Belfast Royal Academy
[8]
and
St Catharine's College, Cambridge
, where he was awarded a Bachelor of Arts degree in 1977
[8]
followed by a PhD in 1981 for research on the
molecular organisation
and
evolution
of
rodent
genomes
[15]
supervised by
Gabriel Dover
.
[4]
Career and research
[
edit
]
Brown conducts research in mouse
genetics
and
genomics
. He has studied
repeated sequences
in the DNA of mice and produced molecular maps of mouse
chromosomes
, which were used to
sequence
the mouse genome.
[4]
[9]
[16]
He subsequently pioneered efforts to functionally annotate the mouse genome and identify and generate novel
disease models
through
mutagenesis
and
phenotyping
. In particular, he has identified key proteins involved in
hearing
, contributing to the understanding of the genetics of
deafness
.
[9]
For example, research in Brown's laboratory has shown that a
mutation
in the
Evi1 gene
increases susceptibility to inflammation of the middle ear (
otitis media
) in mice, leading to hearing loss.
[17]
A particular focus has been the use of mouse models to elucidate the molecular basis of genetic deafness. With
Karen Steel
, he discovered
myosin VIIA
as the gene underlying the
shaker-1 mutant
? one of the first deafness genes to be identified.
[18]
Prior to being appointed director of Harwell in 1998, Brown was a professor at
Imperial College London
.
[19]
He is chair of the
International Mouse Phenotyping Consortium
steering committee and joint editor-in-chief of the journal
Mammalian Genome
.
[20]
[21]
Awards and honours
[
edit
]
Brown was awarded
The Genetics Society
Medal in 2009,
[
citation needed
]
elected a Fellow of the
Academy of Medical Sciences
in 2001,
[1]
and elected a
Fellow of the Royal Society (FRS) in 2015
.
[9]
[18]
His certificate of election reads:
Stephen Brown is distinguished for his research in mouse genetics and genomics. He pioneered studies of repeated sequences in the mouse
genome
and the use of novel approaches to generate molecular maps of mouse
chromosomes
, work that underpinned the sequencing of the mouse genome. He has been at the forefront of new approaches in
mutagenesis
and
phenotyping
for the functional annotation of the mouse genome and the identification and characterisation of disease models. Notably, in collaboration he has utilised the mouse to study the
genetics of deafness
, identifying key
proteins
involved in
auditory transduction
, which has transformed our understanding in this field.
[9]
References
[
edit
]
- ^
a
b
c
"Professor Steve Brown FRS FMedSci"
. London: Academy of Medical Sciences. Archived from
the original
on 4 June 2015.
- ^
Brown, S. D.; Hancock, J. M.; Gates, H (2006).
"Understanding mammalian genetic systems: The challenge of phenotyping in the mouse"
.
PLOS Genetics
.
2
(8): e118.
doi
:
10.1371/journal.pgen.0020118
.
PMC
1557775
.
PMID
16933996
.
- ^
Steel, Karen P.; Brown, Stephen D.M. (1994). "Genes and deafness".
Trends in Genetics
.
10
(12): 428?35.
doi
:
10.1016/0168-9525(94)90113-9
.
PMID
7871592
.
- ^
a
b
c
Brown, S. D. M.; Dover, G. A. (1980). "Conservation of segmental variants of satellite DNA of Mus musculus in a related species: Mus spretus".
Nature
.
285
(5759): 47?49.
Bibcode
:
1980Natur.285...47B
.
doi
:
10.1038/285047a0
.
ISSN
0028-0836
.
PMID
7374752
.
S2CID
4326610
.
- ^
Dover, G. A.; Strachan, T; Coen, E. S.; Brown, S. D. (1982). "Molecular drive".
Science
.
218
(4577): 1069.
Bibcode
:
1982Sci...218.1069D
.
doi
:
10.1126/science.7146895
.
PMID
7146894
.
- ^
Brown, S. D.; Dover, G (1981). "Organization and evolutionary progress of a dispersed repetitive family of sequences in widely separated rodent genomes".
Journal of Molecular Biology
.
150
(4): 441?66.
doi
:
10.1016/0022-2836(81)90374-0
.
PMID
6276556
.
- ^
Fisher, Elizabeth Mary Claire (1987).
Microcloning and molecular mapping of the mouse X chromosome
.
london.ac.uk
(PhD thesis). University of London.
hdl
:
10044/1/66999
.
OCLC
1103939662
.
EThOS
uk.bl.ethos.769180
.
- ^
a
b
c
d
Anon (2016).
"Brown, Stephen David Macleod"
.
Who's Who
(online
Oxford University Press
ed.). Oxford: A & C Black.
doi
:
10.1093/ww/9780199540884.013.U284101
.
(Subscription or
UK public library membership
required.)
- ^
a
b
c
d
e
f
Anon (2015).
"Professor Stephen Brown FMedSci FRS"
. London:
Royal Society
. Archived from
the original
on 2 May 2015.
- ^
Silver, L. M.; Nadeau, J. H.; Brown, S. D. M.; Eppig, J. T.; Peters, J (1998). "Mammalian Genome, Incorporating Mouse Genome".
Mammalian Genome
.
9
(1): 1.
doi
:
10.1007/s003359900669
.
PMID
9435276
.
S2CID
42368624
.
- ^
Brown, S. D.; Moore, M. W. (2012).
"The International Mouse Phenotyping Consortium: Past and future perspectives on mouse phenotyping"
.
Mammalian Genome
.
23
(9?10): 632?40.
doi
:
10.1007/s00335-012-9427-x
.
PMC
3774932
.
PMID
22940749
.
- ^
Brown, S. D. M.; Moore, M. W. (2012).
"Towards an encyclopaedia of mammalian gene function: the International Mouse Phenotyping Consortium"
.
Disease Models & Mechanisms
.
5
(3): 289?292.
doi
:
10.1242/dmm.009878
.
ISSN
1754-8403
.
PMC
3339821
.
PMID
22566555
.
- ^
"Profile: Steve Brown"
. Medical Research Council. Archived from
the original
on 4 June 2015.
- ^
"Genetics and Pathobiology of Deafness research group"
. Harwell: MRC Harwell.
- ^
Brown, Stephen D. M. (1981).
The molecular organisation and evolution of rodent genomes
.
cam.ac.uk
(PhD thesis). University of Cambridge.
OCLC
556404448
.
EThOS
uk.bl.ethos.252843
.
- ^
Brown, S. D.
;
Dover, G
(1981). "Organization and evolutionary progress of a dispersed repetitive family of sequences in widely separated rodent genomes".
Journal of Molecular Biology
.
150
(4): 441?66.
doi
:
10.1016/0022-2836(81)90374-0
.
PMID
6276556
.
- ^
Parkinson, N; Hardisty-Hughes, R. E.; Tateossian, H; Tsai, H. T.; Brooker, D; Morse, S; Lalane, Z; MacKenzie, F; Fray, M; Glenister, P; Woodward, A. M.; Polley, S; Barbaric, I; Dear, N; Hough, T. A.; Hunter, A. J.; Cheeseman, M. T.; Brown, S. D. (2006).
"Mutation at the Evi1 locus in Junbo mice causes susceptibility to otitis media"
.
PLOS Genetics
.
2
(10): e149.
doi
:
10.1371/journal.pgen.0020149
.
PMC
1592239
.
PMID
17029558
.
- ^
a
b
Anon (2015).
"Professor Steve Brown FMedSci FRS"
. London:
Royal Society
. Archived from
the original
on 17 November 2015.
One or more of the preceding sentences incorporates text from the royalsociety.org website where:
"All text published under the heading 'Biography' on Fellow profile pages is available under
Creative Commons Attribution 4.0 International License
." --
"Royal Society Terms, conditions and policies"
. Archived from the original on 25 September 2015
. Retrieved
9 March
2016
.
{{
cite web
}}
: CS1 maint: unfit URL (
link
)
- ^
"MRC Harwell Timeline"
. Medical Research Council. Archived from
the original
on 24 September 2014.
- ^
"Mammalian Genome: Editorial Board"
. Springer
. Retrieved
14 August
2015
.
- ^
"IMPC Steering Committee"
. International Mouse Phenotyping Consortium.
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