From Wikipedia, the free encyclopedia
Danish scientist
Steen Willadsen
|
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Born
| 1943
|
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Alma mater
| Royal Veterinary College of Copenhagen
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Known for
| The first cloning of a sheep.
|
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Awards
| Recipient of the Royal Agricultural Society of England's Gold Medal for Research, 1985, and the International Embryo Transfer Society's Pioneer Award, 2005
[1]
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Scientific career
|
Fields
| embryologist
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|
Steen Malte Willadsen
(born 1943 in
Copenhagen
,
Denmark
) is a Danish
biologist
credited with being the first to
clone
a mammal using
nuclear transfer
.
Willadsen graduated from the
Royal Veterinary College of Copenhagen
in 1969, and received a PhD in reproductive physiology there in 1973. In 1984, at the British
Agricultural Research Council
's Institute of Animal Physiology, Cambridge, he successfully used cells from early embryos to clone sheep by nuclear transfer.
[2]
[3]
The procedure he developed was essentially identical to the one used to create
Dolly the sheep
, although nuclei from a mature sheep were used instead of sheep embryos. Prior to the nuclear transfer experiments, Willadsen had developed methods for freezing sheep and cow embryos,
[4]
embryo manipulation methods for producing genetically identical animals (primarily identical twins in sheep, cattle, pigs, and horses),
[5]
and for producing mammalian chimaeras, including interspecies chimaeras.
[6]
References
[
edit
]
- ^
Reproduction, Fertility and Development 2005, 17
- ^
Willadsen, Steen M. (1986-03-06).
"Nuclear transplantation in sheep embryos"
.
Nature
.
320
(6057): 63?65.
doi
:
10.1038/320063a0
.
ISSN
1476-4687
.
- ^
Willadsen, Steen M. (1989-01-15).
"Cloning of sheep and cow embryos"
.
Genome
.
31
(2): 956?962.
doi
:
10.1139/g89-167
.
ISSN
0831-2796
.
- ^
Willadsen, Steen M. (January 1977). Elliott, Katherine; Whelan, Julie (eds.).
"Factors affecting the survival of sheep embryos during deep-freezing and thawing"
.
Novartis Foundation Symposia
.
52
: 175?201.
doi
:
10.1002/9780470720332.ch9
.
ISBN
978-0-85708-010-3
.
- ^
Willadsen, Steen M. (1979-01-25).
"A method for culture of micromanipulated sheep embryos and its use to produce monozygotic twins"
.
Nature
.
277
(5694): 298?300.
doi
:
10.1038/277298a0
.
ISSN
0028-0836
.
- ^
Fehilly, Carole B.; Willadsen, Steen M.; Tucker, Elizabeth M. (1984-02-16).
"Interspecific chimaerism between sheep and goat"
.
Nature
.
307
(5952): 634?636.
doi
:
10.1038/307634a0
.
ISSN
0028-0836
.
External links
[
edit
]