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Sangassou orthohantavirus

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Sangassou orthohantavirus
Virus classification Edit this classification
(unranked): Virus
Realm : Riboviria
Kingdom: Orthornavirae
Phylum: Negarnaviricota
Class: Ellioviricetes
Order: Bunyavirales
Family: Hantaviridae
Genus: Orthohantavirus
Species:
Sangassou orthohantavirus
Synonyms [1]
  • Sangassou hantavirus
  • Sangassou virus

Sangassou orthohantavirus (SANGV) is single-stranded, negative-sense RNA virus species of the genus Orthohantavirus in the Bunyavirales order. It was first isolated in an African wood mouse ( Hylomyscus simus ) in the forest in Guinea , West Africa in 2010. It is named for the village near where the mouse was trapped. It is the first indigenous Murinae -associated African hantavirus to be discovered. [2]

Genome [ edit ]

The virus genome consists of three segments of negative-stranded RNA; the large (L) segment encodes the viral RNA-dependent RNA polymerase , the medium (M) segment encodes the envelope glycoproteins Gn and Gc (cotranslationally cleaved from a glycoprotein precursor), and the small (S) segment encodes the nucleocapsid (N) protein. [2]

Renal syndrome [ edit ]

In rodents, hantavirus produces a chronic infection with no adverse sequelae . In humans, hantavirus produces two major clinical syndromes: hemorrhagic fever or pulmonary syndrome . European, Asian, and African rodent-borne hantaviruses cause hemorrhagic fever. The pulmonary syndrome, caused by the species Sin Nombre orthohantavirus , has not been found anywhere other than the United States [ dubious – discuss ] where deer mice are the natural hosts. It was discovered in 1993 during an outbreak in the Four Corners region of the southwestern United States. [3] [4]

Reservoirs [ edit ]

Natural reservoirs for this hantavirus species include the slit faced bat , moles , and shrews . Rodent-borne hantaviruses form three major evolutionary clades corresponding to the subfamilies of their rodent hosts. HTNV , SEOV , and DOBV are examples of Murinae-associated hantaviruses. PUUV and Tula orthohantavirus (TULV) belong to the Arvicolinae -associated hantaviruses, and SNV and ANDV are representatives of Neotominae - and Sigmodontinae -associated hantaviruses. [2] [5]

See also [ edit ]

References [ edit ]

  1. ^ Briese, Thomas; et al. (15 June 2015). "Implementation of non-Latinized binomial species names in the family Bunyaviridae " (PDF) . International Committee on Taxonomy of Viruses (ICTV) . Retrieved 8 March 2019 .
  2. ^ a b c Klempa, B.; Witkowski, P. T.; Popugaeva, E.; Auste, B.; Koivogui, L.; Fichet-Calvet, E.; Strecker, T.; Ter Meulen, J.; Kruger, D. H. (2012). "Sangassou Virus, the First Hantavirus Isolate from Africa, Displays Genetic and Functional Properties Distinct from Those of Other Murinae-Associated Hantaviruses" . Journal of Virology . 86 (7): 3819?3827. doi : 10.1128/JVI.05879-11 . PMC   3302504 . PMID   22278233 .
  3. ^ "CDC?Hemorrhagic Fever with Renal Syndrome (HFRS)?Hantavirus" . Cdc.gov. 2011-05-17 . Retrieved 2013-04-13 .
  4. ^ Peters CJ, Simpson GL, Levy H (1999). "Spectrum of hantavirus infection: hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome". Annu. Rev. Med . 50 : 531?45. doi : 10.1146/annurev.med.50.1.531 . PMID   10073292 .
  5. ^ Klempa, B.; Fichet-Calvet, E.; Lecompte, E.; Auste, B.; Aniskin, V.; Meisel, H.; Barriere, P.; Koivogui, L.; Ter Meulen, J.; Kruger, D. H. (2007). "Novel Hantavirus Sequences in Shrew, Guinea" . Emerging Infectious Diseases . 13 (3): 520?522. doi : 10.3201/eid1303.061198 . PMC   2725914 . PMID   17554814 .

External links [ edit ]

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