From Wikipedia, the free encyclopedia
Radiosynthesis
is a
fully automated synthesis
method in which
radioactive compounds
are produced.
[1]
Radiosynthesis is generally carried out by several
nuclear interface modules
, which are protected by the
lead shielding
and controlled by a computer semi-automatically. The set-ups of modules are different depending on the type of product and
synthesis process
. Consequently, the modules should be adapted with the synthesis stages. In some cases, such stages of synthesis are carried out manually in order to optimize the
radiochemical
yield or due to the incompatibility or lack of module.
[2]
Module
[
edit
]
Radiosynthesis modules consist of following constant components:
There are also some components which are added based on the synthesis set-up such as stirrers, sterile filters, Sep-Paks™, vials, bottles, detectors etc..
Before every synthesis, the modules should be washed. It should also be mentioned that according to Half-life of radionuclides, a relaxation time is needed between the syntheses in each module. Fig.1 shows the schematic of a sample module.
Radiosynthesis modules are often combined with a
cyclotron
or other
radio nuclide generator
.
See also
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References
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