Peter Colman

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Peter Colman
AC FRS FAA FTSE
Peter Colman at the Royal Society admissions day in 2014
Born
Peter Malcolm Colman

( 1944-04-03 ) 3 April 1944 (age 80) [5]
Adelaide [3]
Alma mater
Known for
Awards
Scientific career
Fields
Institutions
Thesis The physical structure of two parabanic acid complexes and an investigation of short intermolecular carbon-oxygen contacts   (1969)
Doctoral advisor Harry Medlin [4]
Website www .wehi .edu .au /people /peter-colman

Peter Malcolm Colman AC FRS FAA FTSE (born 1944) [5] is the head of the structural biology division at the Walter and Eliza Hall Institute of Medical Research in Melbourne , Australia. [7]

Education [ edit ]

Colman was educated at the University of Adelaide , where he received a Bachelor of Science degree in physics in 1966 [5] and a PhD in 1969 for research on the chemical structure of parabanic acid complexes supervised by Harry Medlin . [4]

Research and career [ edit ]

Colman's research interests are in structural biology , [8] [9] [10] especially of human B-cell lymphoma 2 (BCL-2) . [11] [12] [13] [14] Colman determined the three-dimensional structure of the influenza virus neuraminidase and, in one of the earliest cases of structure-based drug design, discovered zanamivir , the first-in-class neuraminidase inhibitor for influenza . [15] His subsequent structural studies on resistance to this drug class suggested how to design drugs against moving targets. [15] His discoveries underpin drug stockpiling for pandemic preparedness . [15] He has made seminal contributions to structural studies of antibodies and antibody-antigen complexes . [15] Recent [ when? ] work on apoptosis solves the long-standing problem of how pro-apoptotic Bax changes conformation to dimerise and then oligomerise and permeabilise the mitochondrial membrane , an essential step in the intrinsic cell-death pathway . [15]

His work has been published in leading peer reviewed scientific journals including Nature , [8] [16] [17] [18] [19] [20] the Journal of Molecular Biology , [21] and Nature Reviews Molecular Cell Biology . [22]

Awards and honours [ edit ]

Peter Colman, showing his flu protein (neuraminidase) model to Frank Macfarlane Burnet .

In the Queen's 2017 Birthday Honours Colman was appointed a Companion of the Order of Australia (AC), Australia's highest civilian honour, "for eminent service to medical research, particularly in the fields of structural biology and medicinal chemistry, as a leader in the commercial translation of scientific discoveries, to professional organisations, and as a mentor of young scientists". [23]

Colman was elected a Fellow of the Royal Society (FRS) in 2014. [15] In 2001 he was awarded a Centenary Medal "For service to Australian society and science in structural biology". [2] Colman was also elected a Fellow of the Australian Academy of Science in 1989 and a Fellow of the Australian Academy of Technological Sciences and Engineering in 1997. [5] He was awarded the Lemberg Medal in 1988 [24] and the Macfarlane Burnet Medal and Lecture in 1995. [25]

References [ edit ]

  1. ^ "Professor Peter Colman" . aips.net . Australian Institute of Policy and Science .
  2. ^ a b COLMAN, Peter Malcolm - Centenary Medal , 1 January 2001, It's an Honour.
  3. ^ a b Peter Malcolm Colman, CSIROpedia , Commonwealth Scientific and Industrial Research Organisation
  4. ^ a b Colman, Peter Malcolm (1969). The physical structure of two parabanic acid complexes and an investigation of short intermolecular carbon-oxygen contacts . trove.nla.gov.au (PhD thesis). University of Adelaide. hdl : 2440/19998 . OCLC   222734513 . Free access icon
  5. ^ a b c d Anon (2014). "Colman, Dr Peter Malcolm" . Who's Who (online Oxford University Press  ed.). A & C Black. doi : 10.1093/ww/9780199540884.013.U23546 . (Subscription or UK public library membership required.)
  6. ^ Colman, P. M. (1994). "Influenza virus neuraminidase: Structure, antibodies, and inhibitors" . Protein Science . 3 (10): 1687?96. doi : 10.1002/pro.5560031007 . PMC   2142611 . PMID   7849585 .
  7. ^ Peter Colman publications indexed by the Scopus bibliographic database. (subscription required)
  8. ^ a b Huber, R. ; Deisenhofer, J. ; Colman, P. M. ; Matsushima, M.; Palm, W. (1976). "Crystallographic structure studies of an IgG molecule and an Fc fragment". Nature . 264 (5585): 415?20. Bibcode : 1976Natur.264..415H . doi : 10.1038/264415a0 . PMID   1004567 . S2CID   4193312 .
  9. ^ Colman, P. M. (1994). "Effects of amino acid sequence changes on antibody-antigen interactions". Research in Immunology . 145 (1): 33?6. doi : 10.1016/S0923-2494(94)80039-1 . PMID   7516563 .
  10. ^ Type 1 Diabetes Research Update ? with Professor Peter Colman on YouTube
  11. ^ Lessene, G.; Czabotar, P. E.; Colman, P. M. (2008). "BCL-2 family antagonists for cancer therapy". Nature Reviews Drug Discovery . 7 (12): 989?1000. doi : 10.1038/nrd2658 . PMID   19043450 . S2CID   7385925 .
  12. ^ Brady, R. M.; Vom, A.; Roy, M. J.; Toovey, N.; Smith, B. J.; Moss, R. M.; Hatzis, E.; Huang, D. C. S.; Parisot, J. P.; Yang, H.; Street, I. P.; Colman, P. M.; Czabotar, P. E.; Baell, J. B.; Lessene, G. (2014). "De-Novo Designed Library of Benzoylureas as Inhibitors of BCL-XL: Synthesis, Structural and Biochemical Characterization". Journal of Medicinal Chemistry . 57 (4): 1323?43. doi : 10.1021/jm401948b . PMID   24456288 .
  13. ^ Koehler, M. F. T.; Bergeron, P.; Choo, E. F.; Lau, K.; Ndubaku, C.; Dudley, D.; Gibbons, P.; Sleebs, B. E.; Rye, C. S.; Nikolakopoulos, G.; Bui, C.; Kulasegaram, S.; Kersten, W. J. A.; Smith, B. J.; Czabotar, P. E.; Colman, P. M.; Huang, D. C. S.; Baell, J. B.; Watson, K. G.; Hasvold, L.; Tao, Z. F.; Wang, L.; Souers, A. J.; Elmore, S. W.; Flygare, J. A.; Fairbrother, W. J.; Lessene, G. (2014). "Structure-Guided Rescaffolding of Selective Antagonists of BCL-XL" . ACS Medicinal Chemistry Letters . 5 (6): 662?7. doi : 10.1021/ml500030p . PMC   4060937 . PMID   24944740 .
  14. ^ Chen, L.; Willis, S. N.; Wei, A.; Smith, B. J.; Fletcher, J. I.; Hinds, M. G.; Colman, P. M.; Day, C. L.; Adams, J. M.; Huang, D. C. S. (2005). "Differential Targeting of Prosurvival Bcl-2 Proteins by Their BH3-Only Ligands Allows Complementary Apoptotic Function" . Molecular Cell . 17 (3): 393?403. doi : 10.1016/j.molcel.2004.12.030 . PMID   15694340 .
  15. ^ a b c d e f Anon (2014). "Professor Peter Colman FRS" . royalsociety.org . London: Royal Society . Archived from the original on 5 May 2015. One or more of the preceding sentences incorporates text from the royalsociety.org website where:

    “All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License .” -- Royal Society Terms, conditions and policies at the Wayback Machine (archived 2016-11-11)

  16. ^ von Itzstein, M.; Wu, W. Y.; Kok, G. B.; Pegg, M. S.; Dyason, J. C.; Jin, B.; Phan, T. V.; Smythe, M. L.; White, H. F.; Oliver, S. W.; Colman, P. M.; Varghese, J. N.; Ryan, D. M.; Woods, J. M.; Bethell, R. C.; Hotham, V. J.; Cameron, J. M.; Penn, C. R. (1993). "Rational design of potent sialidase-based inhibitors of influenza virus replication". Nature . 363 (6428): 418?23. Bibcode : 1993Natur.363..418V . doi : 10.1038/363418a0 . PMID   8502295 . S2CID   4359333 .
  17. ^ Chothia, C. ; Lesk, A. M. ; Tramontano, A.; Levitt, M. ; Smith-Gill, S. J.; Air, G.; Sheriff, S.; Padlan, E. A.; Davies, D.; Tulip, W. R.; Colman, P. M. ; Spinelli, S.; Alzari, P. M.; Poljak, R. J. (1989). "Conformations of immunoglobulin hypervariable regions". Nature . 342 (6252): 877?883. Bibcode : 1989Natur.342..877C . doi : 10.1038/342877a0 . PMID   2687698 . S2CID   4241051 .
  18. ^ Varghese, J. N.; Laver, W. G.; Colman, P. M. (1983). "Structure of the influenza virus glycoprotein antigen neuraminidase at 2.9 A resolution". Nature . 303 (5912): 35?40. Bibcode : 1983Natur.303...35V . doi : 10.1038/303035a0 . PMID   6843658 . S2CID   4363648 .
  19. ^ Colman, P. M.; Laver, W. G.; Varghese, J. N.; Baker, A. T.; Tulloch, P. A.; Air, G. M.; Webster, R. G. (1987). "Three-dimensional structure of a complex of antibody with influenza virus neuraminidase". Nature . 326 (6111): 358?63. Bibcode : 1987Natur.326..358C . doi : 10.1038/326358a0 . PMID   2436051 . S2CID   4239913 .
  20. ^ Colman, P. M.; Varghese, J. N.; Laver, W. G. (1983). "Structure of the catalytic and antigenic sites in influenza virus neuraminidase". Nature . 303 (5912): 41?4. Bibcode : 1983Natur.303...41C . doi : 10.1038/303041a0 . PMID   6188957 . S2CID   4325977 .
  21. ^ Lawrence, M. C.; Colman, P. M. (1993). "Shape Complementarity at Protein/Protein Interfaces". Journal of Molecular Biology . 234 (4): 946?50. doi : 10.1006/jmbi.1993.1648 . PMID   8263940 .
  22. ^ Colman, P. M.; Lawrence, M. C. (2003). "The structural biology of type I viral membrane fusion". Nature Reviews Molecular Cell Biology . 4 (4): 309?19. doi : 10.1038/nrm1076 . PMID   12671653 . S2CID   31703688 .
  23. ^ Companion (AC) in the General Division of the Order of Australia Archived 22 March 2018 at the Wayback Machine , Media Notes, Queen's Birthday 2017, www.gg.gov.au
  24. ^ "Lemberg Medal Winners" . Australian Society for Biochemistry and Molecular Biology . Retrieved 31 January 2024 .
  25. ^ "Macfarlane Burnet Medal and Lecture" . Australian Academy of Science . Retrieved 22 February 2017 .

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