From Wikipedia, the free encyclopedia
Chemical compound
Oxolinic acid
is a
quinolone
antibiotic
developed in Japan in the 1970s.
[1]
[2]
Dosages 12?20 mg/kg orally administered for five to ten days. The antibiotic works by inhibiting the enzyme
DNA gyrase
. It also acts as a
dopamine reuptake inhibitor
and has stimulant effects in mice.
[3]
See also
[
edit
]
References
[
edit
]
- ^
JP Patent 49138244
- ^
Gleckman R, Alvarez S, Joubert DW, Matthews SJ (August 1979). "Drug therapy reviews: oxolinic acid".
American Journal of Hospital Pharmacy
.
36
(8): 1077?9.
PMID
384788
.
- ^
Garcia de Mateos-Verchere J, Vaugeois JM, Naudin B, Costentin J (December 1998). "Behavioural and neurochemical evidence that the antimicrobial agent oxolinic acid is a dopamine uptake inhibitor".
European Neuropsychopharmacology
.
8
(4): 255?9.
doi
:
10.1016/S0924-977X(97)00083-7
.
PMID
9928913
.
S2CID
22626555
.