Human sleep disorder
Medical condition
Narcolepsy
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![](//upload.wikimedia.org/wikipedia/commons/thumb/2/2d/1R02_crystallography.png/220px-1R02_crystallography.png) |
The concentration of
orexin-A
neuropeptides in the
cerebrospinal fluid
of narcoleptic individuals is usually very low
|
Pronunciation
| |
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Specialty
| Sleep medicine
,
neurology
|
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Symptoms
| Excessive daytime sleepiness
, involuntary sleep episodes,
sudden loss of muscle strength
,
hallucinations
[1]
|
---|
Complications
| Motor vehicle collisions
,
falls
[1]
|
---|
Usual onset
| Childhood
[1]
|
---|
Duration
| Long term
[1]
|
---|
Causes
| Orexin
deficiency
[1]
|
---|
Risk factors
| Family history, brain injury
[1]
|
---|
Diagnostic method
| Based on the symptoms and
sleep studies
[1]
|
---|
Differential diagnosis
| Sleep apnea
,
major depressive disorder
,
anemia
,
heart failure
, drinking
alcohol
,
idiopathic hypersomnia
,
Sleep deprivation
[1]
|
---|
Treatment
| Medication, regular short naps,
sleep hygiene
[1]
|
---|
Medication
| Modafinil
,
sodium oxybate
,
pitolisant
,
methylphenidate
,
amphetamine
,
stimulants
,
antidepressants
[1]
|
---|
Frequency
| 0.2 to 600 per 100,000
[2]
|
---|
Narcolepsy
is a
chronic
neurological disorder
that impairs the ability to regulate
sleep?wake cycles
, and specifically impacts REM (rapid eye movement) sleep.
[1]
The pentad symptoms of narcolepsy include
excessive daytime sleepiness
(EDS), sleep related hallucinations, sleep paralysis, disturbed nocturnal sleep (DNS) and cataplexy.
[1]
There are two recognized forms of narcolepsy, narcolepsy type 1 and type 2.
[3]
Narcolepsy type 1 (NT1) can be clinically characterized by symptoms of EDS and
cataplexy
, and/or will have CSF orexin levels of less than 110 pg/ml. Cataplexy are transient episodes of aberrant tone, most typically loss of tone, that can be associated with strong emotion.
[4]
In pediatric onset narcolepsy, active motor phenomena are not uncommon.
[5]
Cataplexy may be mistaken for syncope, tic disorder or
seizures
.
[1]
Narcolepsy type 2 (NT2) does not have features of cataplexy and CSF orexin levels are normal. Sleep related hallucinations, also known as hypnogogic (going to sleep) and hypnopompic (on awakening) are vivid
hallucinations
that can be auditory, visual or tactile and may occur independent of or in combination with an inability to move (
sleep paralysis
). People with narcolepsy tend to sleep about the same number of hours per day as people without it, but the quality of sleep is typically compromised.
[1]
Narcolepsy is a clinical syndrome of hypothalamic disorder,
[6]
but the exact cause of narcolepsy is unknown, with potentially several causes.
[7]
A leading consideration for the cause of narcolepsy type 1 is that it is an
autoimmune disorder
.
[8]
Proposed pathophysiology as an autoimmune disease suggest antigen presentation by DQ0602 to specific CD4+ T cells resulting in CD8+ T-cell activation and consequent injury to orexin producing neurons.
[9]
Familial trends of narcolepsy are suggested to be higher than previously appreciated. Familial risk of narcolepsy among first degree relatives is high. Relative risk for narcolepsy in a first degree relative has been reported to be 361.8.
[10]
However, it is important to note that there is a spectrum of symptoms found in this study, including asymptomatic abnormal sleep test findings to significantly symptomatic.
[11]
The autoimmune process is thought to be triggered in genetically susceptible individuals by an immune provoking experience, such as infection with
H1N1 influenza
.
[12]
Secondary narcolepsy can occur as a consequence of another neurologic disorder. Secondary narcolepsy can be seen in some individuals with traumatic brain injury, tumors, Prader Willi Syndrome or other diseases affecting the parts of the brain that regulate wakefulness or
REM sleep
. Diagnosis is typically based on the symptoms and
sleep studies
, after excluding alternative caused of EDS. EDS can also be caused by other
sleep disorders
such as insufficient sleep syndrome,
sleep apnea
,
major depressive disorder
,
anemia
,
heart failure
, and drinking
alcohol
.
While there is no cure, behavioral strategies, lifestyle changes, social support and medications may help. Lifestyle and behavioral strategies can include identifying and avoiding or desensitizing emotional triggers for cataplexy, dietary strategies that may reduce sleep inducing foods and drinks, scheduled or strategic naps and maintaining a regular sleep wake schedule. Social support, social networks, and social integration are resources
[13]
that may lie in the communities related to living with narcolepsy. Medications used to treat narcolepsy are primarily targeting EDS and/or cataplexy. These medications include alerting agents (
modafinil
, armodafinil, pitolisant and solriamfetol), Oxybate medications (twice nightly
sodium oxybate
, twice nightly mixed salts oxybate and once nightly extended release sodium oxybate), and stimulants (
methylphenidate
and amphetamines). There is also the use of antidepressants, such as
Tricyclic antidepressants
,
selective serotonin reuptake inhibitors
(SSRIs), and selective norepinephrine reuptake inhibitors (SNRIs) for the treatment of cataplexy.
[1]
Estimates of frequency range from 0.2 to 600 per 100,000 people in various countries.
[2]
The condition often begins in childhood, with males and females being affected equally. Untreated narcolepsy increases the risk of
motor vehicle collisions
and
falls
.
[1]
Narcolepsy generally occurs anytime between early childhood and 50 years of age, and most commonly between 15 and 36 years of age. However, it may also rarely appear at any time outside of this range.
[14]
Signs and symptoms
[
edit
]
There are two main characteristics of narcolepsy:
excessive daytime sleepiness
and abnormal
REM sleep
.
[15]
Excessive daytime sleepiness occurs even after adequate night time sleep. A person with narcolepsy is likely to become drowsy or fall asleep, often at inappropriate or undesired times and places, or just be very tired throughout the day. Narcoleptics may not be able to experience the amount of restorative deep sleep that healthy people experience due to abnormal REM regulation ? they are not "over-sleeping". Narcoleptics typically have higher REM sleep density than non-narcoleptics, but also experience more REM sleep without
atonia
.
[16]
Many narcoleptics have sufficient REM sleep, but do not feel refreshed or alert throughout the day.
[17]
This can feel like living their entire lives in a constant state of sleep deprivation.
[
medical citation needed
]
Excessive sleepiness can vary in severity, and it appears most commonly during monotonous situations that do not require much interaction.
[17]
Daytime naps may occur with little warning and may be physically irresistible. These naps can occur several times a day. They are typically refreshing, but only for a few hours or less. Vivid dreams may be experienced on a regular basis, even during very brief naps. Drowsiness may persist for prolonged periods or remain constant. In addition, night-time sleep may be fragmented, with frequent awakenings. A second prominent symptom of narcolepsy is abnormal REM sleep. Narcoleptics are unique in that they enter into the REM phase of sleep in the beginnings of sleep, even when sleeping during the day.
[15]
The classic symptoms of the disorder, often referred to as the "tetrad of narcolepsy", are
cataplexy
,
sleep paralysis
,
hypnagogic hallucinations
, and excessive daytime sleepiness.
[18]
Other symptoms may include automatic behaviors and night-time wakefulness.
[15]
[19]
[20]
These symptoms may not occur in all people with narcolepsy.
- An episodic loss of muscle function, known as cataplexy, ranging from slight weakness such as limpness at the neck or knees, sagging facial muscles, weakness at the knees often referred to as "knee buckling",
[21]
or inability to speak clearly, to a complete body collapse. Episodes may be triggered by sudden emotional reactions such as
laughter
,
anger
, surprise, or
fear
. The person remains conscious throughout the episode. In some cases, cataplexy may resemble epileptic seizures.
[22]
Usually speech is slurred and vision is impaired (double vision, inability to focus), but hearing and awareness remain normal. Cataplexy also has a severe emotional impact on narcoleptics, as it can cause extreme anxiety, fear, and avoidance of people or situations that might elicit an attack. Cataplexy is generally considered to be unique to narcolepsy and is analogous to sleep paralysis in that the usually protective paralysis mechanism occurring during sleep is inappropriately activated. The opposite of this situation (failure to activate this protective paralysis) occurs in
rapid eye movement behavior disorder
.
[
medical citation needed
]
- Periods of wakefulness at night
[15]
- The temporary inability to talk or move when waking (or less often, when falling asleep), known as sleep paralysis. It may last a few seconds to minutes. This is often frightening but is not dangerous.
[
medical citation needed
]
- Vivid, often frightening, dreamlike experiences that occur while dozing or falling asleep, known as hypnagogic hallucinations. Hypnopompic hallucinations refer to the same sensations while awakening from sleep. These hallucinations may manifest in the form of visual or auditory sensations.
[15]
In most cases, the first symptom of narcolepsy to appear is excessive and overwhelming daytime sleepiness. The other symptoms may begin alone or in combination months or years after the onset of the daytime naps. There are wide variations in the development, severity, and order of appearance of cataplexy, sleep paralysis, and hypnagogic hallucinations in individuals. Only about 20 to 25 percent of people with narcolepsy experience all four symptoms. The excessive daytime sleepiness generally persists throughout life, but sleep paralysis and hypnagogic hallucinations may not.
Many people with narcolepsy also have
insomnia
for extended periods of time. The excessive daytime sleepiness and cataplexy often become severe enough to cause serious problems in a person's social, personal, and professional life. Normally, when an individual is awake,
brain waves
show a regular rhythm. When a person first falls asleep, the brain waves become slower and less regular, which is called non-rapid eye movement (
NREM
) sleep. After about an hour and a half of NREM sleep, the brain waves begin to show a more active pattern again, called
REM sleep
(rapid eye movement sleep), when most remembered
dreaming
occurs. Associated with the EEG-observed waves during REM sleep, muscle atonia is present called
REM atonia
.
[
medical citation needed
]
In narcolepsy, the order and length of NREM and REM sleep periods are disturbed, with REM sleep occurring at sleep onset instead of after a period of NREM sleep. Also, some aspects of REM sleep that normally occur only during sleep, like lack of muscular control, sleep paralysis, and vivid dreams, occur at other times in people with narcolepsy. For example, the lack of muscular control can occur during wakefulness in a cataplexy episode; it is said that there is an intrusion of REM atonia during wakefulness. Sleep paralysis and vivid dreams can occur while falling asleep or waking up. Simply put, the brain does not pass through the normal stages of dozing and deep sleep but goes directly into (and out of) rapid eye movement (REM) sleep.
[
medical citation needed
]
As a consequence night time sleep does not include as much deep sleep, so the brain tries to "catch up" during the day, hence excessive daytime sleepiness. People with narcolepsy may visibly fall asleep at unpredicted moments (such motions as head bobbing are common). People with narcolepsy fall quickly into what appears to be very deep sleep, and they wake up suddenly and can be disoriented when they do (dizziness is a common occurrence). They have very vivid dreams, which they often remember in great detail. People with narcolepsy may dream even when they only fall asleep for a few seconds. Along with vivid dreaming, people with narcolepsy are known to have audio or visual hallucinations prior to
falling asleep
or before
waking up
.
[23]
Narcoleptics can
gain excess weight
; children can gain 20 to 40 pounds (9.1 to 18.1 kg) when they first develop narcolepsy; in adults the body-mass index is about 15% above average.
[24]
[25]
Causes
[
edit
]
The exact cause of narcolepsy is unknown, and it may be caused by several distinct factors.
[1]
[7]
The mechanism involves the loss of
orexin
-releasing neurons within the
lateral hypothalamus
(about 70,000 neurons
[26]
).
[27]
[28]
Some researches indicated that people with type 1 narcolepsy (narcolepsy with cataplexy) have a lower level of orexin (hypocretin), which is a chemical contributing to the regulation of wakefulness and REM sleep.
[29]
It also acts as a neurotransmitter to enable nerve cells to communicate.
[14]
In up to 10% of cases there is a family history of the disorder. Family history is more common in narcolepsy with cataplexy.
[1]
There is a strong link with certain genetic variants,
[27]
which may make T-cells susceptible to react to the orexin-releasing neurons (
autoimmunity
)
[30]
after being stimulated by infection with H1N1 influenza.
[12]
In addition to genetic factors, low levels of orexin peptides have been correlated with a history of infection, diet, contact with toxins such as pesticides, and brain injuries due to head trauma, brain tumors or strokes.
[15]
[27]
Genetics
[
edit
]
The primary genetic factor that has been strongly implicated in the development of narcolepsy involves an area of
chromosome 6
known as the
human leukocyte antigen
(HLA) complex.
[27]
[31]
Specific variations in HLA genes are strongly correlated with the presence of narcolepsy (HLA DQB1*06:02, frequently in combination with HLA DRB1*15:01);
[27]
however, these variations are not required for the condition to occur and sometimes occur in individuals without narcolepsy.
[27]
[32]
These genetic variations in the HLA complex are thought to increase the risk of an
auto-immune
response to
orexin
-releasing neurons in the
lateral hypothalamus
.
[27]
[28]
[32]
The
allele
HLA-DQB1*06:02 of the human gene
HLA-DQB1
was reported in more than 90% of people with narcolepsy, and alleles of other
HLA
genes such as HLA-DQA1*01:02 have been linked. A 2009 study found a strong association with polymorphisms in the
TRAC
gene locus (
dbSNP
IDs rs1154155, rs12587781, and rs1263646).
[26]
A 2013 review article reported additional but weaker links to the loci of the genes
TNFSF4
(rs7553711),
Cathepsin H
(rs34593439), and
P2RY11
-
DNMT1
(rs2305795).
[33]
Another
gene locus
that has been associated with narcolepsy is
EIF3G
(rs3826784).
[34]
H1N1 influenza
[
edit
]
Type 1 narcolepsy is caused by
hypocretin/orexin
neuronal loss. T-cells have been demonstrated to be cross-reactive to both a particular piece of the hemagglutinin flu protein of the pandemic 2009 H1N1 and the amidated terminal ends of the secreted hypocretin peptides.
[12]
Genes associated with narcolepsy mark the particular HLA heterodimer (DQ0602) involved in presentation of these antigens and modulate expression of the specific T cell receptor segments (TRAJ24 and TRBV4-2) involved in T cell receptor recognition of these antigens, suggesting causality.
[12]
A link between
GlaxoSmithKline
's H1N1 flu vaccine
Pandemrix
and narcolepsy has been found in both children and adults.
[35]
In 2010, Finland's
National Institute of Health and Welfare
recommended that Pandemrix vaccinations be suspended pending further investigation into narcolepsy.
[36]
[37]
In 2018, it was demonstrated that T-cells stimulated by Pandemrix were cross-reactive by
molecular mimicry
with part of the hypocretin peptide, the loss of which is associated with type I narcolepsy.
[12]
Pathophysiology
[
edit
]
Loss of neurons
[
edit
]
Orexin, otherwise known as hypocretin, is a
neuropeptide
that acts within the brain to regulate appetite and wakefulness as well as a number of other cognitive and physiological processes.
[27]
[38]
[39]
Loss of these orexin-producing neurons causes narcolepsy and most individuals with narcolepsy have a reduced number of these neurons in their brains.
[27]
[28]
[32]
Selective destruction of the HCRT/OX neurons with preservation of proximate structures suggests a highly specific autoimmune pathophysiology.
[40]
Cerebrospinal fluid HCRT-1/OX-A is undetectable in up to 95% of patients with type 1 narcolepsy.
[40]
The system which regulates sleep, arousal, and transitions between these states in humans is composed of three interconnected subsystems: the
orexin
projections from the
lateral hypothalamus
, the
reticular activating system
, and the
ventrolateral preoptic nucleus
.
[28]
In narcoleptic individuals, these systems are all associated with impairments due to a greatly reduced number of hypothalamic orexin projection neurons and significantly fewer orexin neuropeptides in
cerebrospinal fluid
and neural tissue, compared to non-narcoleptic individuals.
[28]
Those with narcolepsy generally experience the
REM
stage of sleep within five minutes of falling asleep, while people who do not have narcolepsy (unless they are significantly sleep deprived)
[41]
do not experience REM until after a period of
slow-wave sleep
, which lasts for about the first hour or so of a sleep cycle.
[1]
Disturbed sleep states
[
edit
]
The neural control of normal sleep states and the relationship to narcolepsy are only partially understood. In humans, narcoleptic sleep is characterized by a tendency to go abruptly from a waking state to
REM sleep
with little or no intervening
non-REM sleep
. The changes in the motor and
proprioceptive
systems during REM sleep have been studied in both human and animal models. During normal REM sleep, spinal and brainstem
alpha motor neuron
hyperpolarization
produces almost complete
atonia
of
skeletal muscles
via an inhibitory descending reticulospinal pathway.
Acetylcholine
may be one of the
neurotransmitters
involved in this pathway. In narcolepsy, the reflex inhibition of the motor system seen in
cataplexy
has features normally seen only in normal REM sleep.
[1]
Diagnosis
[
edit
]
The third edition of the
International Classification of Sleep Disorders
(ICSD-3) differentiates between narcolepsy with cataplexy (type 1) and narcolepsy without cataplexy (type 2), while the fifth edition of the
Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) uses the diagnosis of narcolepsy to refer to type 1 narcolepsy only. The DSM-5 refers to narcolepsy without cataplexy as hypersomnolence disorder.
[42]
The most recent edition of the
International Classification of Diseases
, ICD-11, currently identifies three types of narcolepsy: type 1 narcolepsy, type 2 narcolepsy, and unspecified narcolepsy.
[43]
ICSD-3 diagnostic criteria posits that the individual must experience "daily periods of irrepressible need to sleep or daytime lapses into sleep" for both subtypes of narcolepsy.
[42]
This symptom must last for at least three months. For a diagnosis of type 1 narcolepsy, the person must present with either cataplexy, a mean
sleep latency
of less than 8 minutes, and two or more sleep-onset REM periods (SOREMPs), or they must present with a hypocretin-1 concentration of less than 110 pg/mL.
[42]
A diagnosis of type 2 narcolepsy requires a mean sleep latency of less than 8 minutes, two or more SOREMPs, and a hypocretin-1 concentration of more than 110 pg/mL. In addition, the hypersomnolence and sleep latency findings cannot be better explained by other causes.
[42]
DSM-5 narcolepsy criteria requires that the person to display recurrent periods of "an irrepressible need to sleep, lapsing into sleep, or napping" for at least three times a week over a period of three months.
[42]
The individual must also display one of the following: cataplexy, hypocretin-1 concentration of less than 110 pg/mL, REM sleep latency of less than 15 minutes, or a
multiple sleep latency test (MSLT)
showing sleep latency of less than 8 minutes and two or more SOREMPs.
[42]
For a diagnosis of
hypersomnolence disorder
, the individual must present with excessive sleepiness despite at least 7 hours of sleep as well as either recurrent lapses into daytime sleep, nonrestorative sleep episodes of 9 or more hours, or difficulty staying awake after awakening. In addition, the hypersomnolence must occur at least three times a week for a period of three months, and must be accompanied by significant distress or impairment. It also cannot be explained by another sleep disorder, coexisting mental or medical disorders, or medication.
[44]
Tests
[
edit
]
Diagnosis is relatively easy when all the symptoms of narcolepsy are present, but if the sleep attacks are isolated and cataplexy is mild or absent, diagnosis is more difficult. Three tests that are commonly used in diagnosing narcolepsy are
polysomnography (PSG)
, the
multiple sleep latency test (MSLT)
, and the
Epworth Sleepiness Scale (ESS)
. These tests are usually performed by a
sleep specialist
.
[45]
Polysomnography involves the continuous recording of sleep brain waves and a number of nerve and muscle functions during night time sleep. When tested, people with narcolepsy fall asleep rapidly, enter REM sleep early, and may often awaken during the night. The polysomnogram also helps to detect other possible sleep disorders that could cause daytime sleepiness.
[
citation needed
]
The Epworth Sleepiness Scale is a brief questionnaire that is administered to determine the likelihood of the presence of a sleep disorder, including narcolepsy.
[
citation needed
]
The multiple sleep latency test is performed after the person undergoes an overnight sleep study. The person will be asked to sleep once every 2 hours, and the time it takes for them to do so is recorded. Most individuals will fall asleep within 5 to 8 minutes, as well as display REM sleep faster than non-narcoleptic people.
[
citation needed
]
Measuring orexin levels in a person's
cerebrospinal fluid
sampled in a
spinal tap
may help in diagnosing narcolepsy, with abnormally low levels serving as an indicator of the disorder.
[46]
This test can be useful when MSLT results are inconclusive or difficult to interpret.
[47]
Treatment
[
edit
]
Orexin replacement
[
edit
]
People with narcolepsy can be substantially helped, but not cured currently. However, the technology exists in early form such as experiments in using the
prepro-orexin
transgene via gene editing restored normal function in mice models by making other neurons produce orexin after the original set have been destroyed, or replacing the missing orexinergic neurons with hypocretin stem cell transplantation, are both steps in that direction for fixing the biology effectively permanently once applied in humans.
[48]
[49]
Additionally effective ideal non-gene editing and chemical-drug methods involve hypocretin treatments methods such as future drugs like hypocretin agonists (such as
danavorexton
)
[50]
or hypocretin replacement, in the form of
hypocretin 1
given
intravenous
(injected into the veins),
intracisternal
(direct injection into the brain), and
intranasal
(sprayed through the nose), the latter being low in efficacy, at the low amount used in current experiments but may be effective at very high doses in the future.
[51]
[52]
Behavioral
[
edit
]
General strategies like people and family education, sleep hygiene and medication compliance, and discussion of safety issues for example driving license can be useful. Potential side effects of medication can also be addressed.
[17]
Regular follow-up is useful to be able to monitor the response to treatment, to assess the presence of other sleep disorders like obstructive sleep apnea, and to discuss psychosocial issues.
[17]
In many cases, planned regular short naps can reduce the need for pharmacological treatment of the EDS, but only improve symptoms for a short duration. A 120-minute nap provided benefit for 3 hours in the person's alertness whereas a 15-minute nap provided no benefit.
[53]
Daytime naps are not a replacement for night time sleep. Ongoing communication between the health care provider, person, and their family members is important for optimal management of narcolepsy.
Medications
[
edit
]
As described above, medications used to treat narcolepsy primarily target EDS and/or cataplexy. Internationally there are differences in the availability of medications as well as guidelines for treatment. The alerting agents are medications typically used to improve wakefulness and include
modafinil
,
armodafinil
,
Pitolisant
and
Solriamfetol
. In late 2007, an alert for severe adverse skin reactions to modafinil was issued by the
FDA
.
[54]
Solriamfetol
is a new molecule indicated for narcolepsy of type 1 and 2.
[55]
Solriamfetol works by inhibiting the reuptake of the monoamines via the interaction with both the dopamine transporter and the norepinephrine transporter. This mechanism differs from that of the wake-promoting agents modafinil and armodafinil. These are thought to bind primarily at the dopamine transporter to inhibit the reuptake of dopamine. Solriamfetol also differs from amphetamines as it does not promote the release of norepinephrine in the brain.
[56]
Uniquely,
Pitolisant
has a novel mechanism of action as an
H3 antagonists
, which promotes the release of the wakefulness-promoting molecule amine histamine. It was initially available in France, United Kingdom's (
NHS
as of September 2016
[update]
[57]
[58]
[59]
[60]
) after being given marketing authorisation by European Commission on the advice of the
European Medicines Agency
and then in the United States by the approval of the
Food and Drug Administration
(FDA) as of August 2019
[update]
.
[61]
Pemoline
was previously used but was withdrawn due to toxicity.
[62]
Traditional stimulants, such as
methylphenidate
and
amphetamine
,
dextroamphetamine
can be used, but are commonly considered second or third line therapy.
Sodium oxybate
,
[63]
also known as sodium
gamma-hydroxybutyrate
(GHB) can be used for
cataplexy
associated with narcolepsy and
excessive daytime sleepiness
associated with narcolepsy.
[63]
[64]
[17]
[65]
There are now three formulations of oxybate medications (twice nightly
sodium oxybate
, twice nightly mixed salts oxybate and once nightly extended release sodium oxybate). This class of medication is taken once or twice during the night, as opposed to other medications for EDS and cataplexy that are typically taken during the day.
Other medications that suppress REM sleep
[66]
may also be used for the treatment of cataplexy as well as potentially other REM dissociative symptoms.
Tricyclic antidepressants
(
clomipramine
,
imipramine
, or
protriptyline
),
selective serotonin reuptake inhibitors
(SSRIs), and selective norepinephrine reuptake inhibitors (SNRIs) (
Venlafaxine
) are used for the treatment of cataplexy.
[1]
Atomoxetine
, a
non-stimulant
and a
norepinephrine reuptake inhibitor
(NRI), which has no addiction liability or recreational effects has been used with variable benefit.
[62]
Other NRIs like
viloxazine
and
reboxetine
have also been used in the treatment of narcolepsy.
[62]
Additional related medications include
mazindol
and
selegiline
.
[62]
Children
[
edit
]
Common behavioral treatments for childhood narcolepsy include improved sleep hygiene, scheduled naps, and physical exercise.
[67]
Many medications are used in treating adults and may be used to treat children. These medications include central nervous system stimulants such as methylphenidate, modafinil, amphetamine, and dextroamphetamine.
[68]
Other medications, such as
sodium oxybate
[55]
or
atomoxetine
, may also be used to counteract sleepiness. Medications such as sodium oxybate,
venlafaxine
,
fluoxetine
, and
clomipramine
may be prescribed if the child presents with cataplexy.
[69]
Epidemiology
[
edit
]
Estimates of frequency range from 0.2 per 100,000 in Israel to 600 per 100,000 in Japan.
[2]
These differences may be due to how the studies were conducted or the populations themselves.
[2]
In the
United States
, narcolepsy is estimated to affect as many as 200,000 Americans, but fewer than 50,000 are diagnosed. The prevalence of narcolepsy is about 1 per 2,000 persons.
[70]
Narcolepsy is often mistaken for
depression
,
epilepsy
, the
side effects
of medications, poor sleeping habits or
recreational drug use
, making misdiagnosis likely.
[
citation needed
]
While narcolepsy symptoms are often confused with depression, there is a link between the two disorders. Research studies have mixed results on co-occurrence of depression in people with narcolepsy, as the numbers quoted by different studies are anywhere between 6% and 50%.
[71]
Narcolepsy can occur in both men and women at any age, although typical symptom onset occurs in
adolescence
and young adulthood. There is about a ten-year delay in diagnosing narcolepsy in adults.
[25]
Cognitive, educational, occupational, and psychosocial problems associated with the excessive daytime sleepiness of narcolepsy have been documented. For these to occur in the crucial teen years when education, development of self-image, and development of occupational choice are taking place is especially devastating. While cognitive impairment does occur, it may only be a reflection of the excessive daytime somnolence.
[72]
Society and culture
[
edit
]
In 2015, it was reported that the British
Department of Health
was paying for
sodium oxybate
medication at a cost of £12,000 a year for 80 people who are taking legal action over problems linked to the use of the
Pandemrix
swine flu vaccine. Sodium oxybate is not available to people with narcolepsy through the
National Health Service
.
[73]
Name
[
edit
]
The term "narcolepsy" is from the French
narcolepsie
.
[74]
The French term was first used in 1880 by
Jean-Baptiste-Edouard Gelineau
, who used the
Greek
ν?ρκη (
nark?
), meaning "numbness", and λ?ψι? (
lepsis
) meaning "attack".
[74]
Research
[
edit
]
GABA-directed medications
[
edit
]
Given the possible role of hyper-active
GABA
A
receptors in the primary hypersomnias (narcolepsy and idiopathic hypersomnia), medications that could counteract this activity are being studied to test their potential to improve sleepiness. These currently include
clarithromycin
and
flumazenil
.
[75]
[76]
Flumazenil
[
edit
]
Flumazenil is the only GABA
A
receptor antagonist on the market as of January 2013, and it is currently manufactured only as an intravenous formulation. Given its pharmacology, researchers consider it to be a promising medication in the treatment of primary hypersomnias. Results of a small, double-blind, randomized, controlled clinical trial were published in November 2012. This research showed that flumazenil provides relief for most people whose CSF contains the unknown "somnogen" that enhances the function of
GABA
A
receptors
, making them more susceptible to the sleep-inducing effect of GABA. For one person, daily administration of flumazenil by sublingual lozenge and topical cream has proven effective for several years.
[75]
[77]
A 2014 case report also showed improvement in primary hypersomnia symptoms after treatment with a continuous subcutaneous flumazenil infusion.
[78]
The supply of generic flumazenil was initially thought to be too low to meet the potential demand for treatment of primary hypersomnias.
[79]
However, this scarcity has eased, and dozens of people are now being treated with flumazenil off-label.
[80]
Clarithromycin
[
edit
]
In a test tube model,
clarithromycin
(an antibiotic approved by the FDA for the treatment of infections) was found to return the function of the GABA system to normal in people with primary hypersomnias. Investigators therefore treated a few people with narcolepsy with off-label clarithromycin, and most felt their symptoms improved with this treatment. In order to help further determine whether clarithromycin is truly beneficial for the treatment of narcolepsy and idiopathic hypersomnia, a small, double-blind, randomized, controlled clinical trial was completed in 2012.
[76]
"In this pilot study, clarithromycin improved subjective sleepiness in GABA-related hypersomnia. Larger trials of longer duration are warranted."
[81]
In 2013, a retrospective review evaluating longer-term clarithromycin use showed efficacy in a large percentage of people with GABA-related hypersomnia.
[82]
"It is important to note that the positive effect of clarithromycin is secondary to a benzodiazepine antagonist-like effect, not its antibiotic effects, and treatment must be maintained."
[83]
Orexin receptor agonists
[
edit
]
Orexin-A
(
a.k.a.
hypocretin-1) has been shown to be strongly wake-promoting in animal models, but it does not cross the
blood?brain barrier
. The first line treatment for narcolepsy,
modafinil
, has been found to interact indirectly with the orexin system. It is also likely that an
orexin receptor
agonist
will be found and developed for the treatment of hypersomnia.
[83]
One such agent which is currently in clinical trials is
danavorexton
.
[84]
[85]
L-carnitine
[
edit
]
Abnormally low levels of
acylcarnitine
have been observed in people with narcolepsy.
[86]
These same low levels have been associated with primary hypersomnia in general in mouse studies. "Mice with systemic carnitine deficiency exhibit a higher frequency of fragmented wakefulness and rapid eye movement (REM) sleep, and reduced locomotor activity." Administration of
acetyl-L-carnitine
was shown to improve these symptoms in mice.
[87]
A subsequent human trial found that people with narcolepsy given L-carnitine spent less total time in daytime sleep than people who were given a placebo.
[88]
Animal models
[
edit
]
Animal studies try to mimic the disorder in humans by either modifying the Hypocretin/Orexin receptors or by eliminating this peptide.
[89]
An orexin deficit caused by the degeneration of hypothalamic neurons is suggested to be one of the causes of narcolepsy.
[90]
More recent clinical studies on both animals and humans have also revealed that hypocretin is involved in other functions beside regulation of wakefulness and sleep. These functions include autonomic regulation, emotional processing, reward learning behaviour or energy homeostasis. In studies where the concentration of the hypocretin was measured under different circumstances, it was observed that the hypocretin levels increased with the positive emotion, anger or social interaction but stayed low during sleep or during pain experience.
[91]
The most reliable and valid animal models developed are the canine (narcoleptic dogs) and the rodent (orexin-deficient mice) ones which helped investigating the narcolepsy and set the focus on the role of orexin in this disorder.
[90]
Dog models
[
edit
]
Dogs, as well as other species like cats or horses, can also exhibit spontaneous narcolepsy with similar symptoms as the ones reported in humans. The attacks of cataplexy in dogs can involve partial or full collapse.
[90]
Narcolepsy with cataplexy was identified in a few breeds like Labrador retrievers or Doberman pinschers where it was investigated the possibility to inherit this disorder in the autosomal recessive mode.
[92]
According to
[89]
a reliable canine model for narcolepsy would be the one in which the narcoleptic symptoms are the result of a mutation in the gene HCRT 2. The animals affected exhibited excessive daytime sleepiness with a reduced state of vigilance and severe cataplexy resulted after palatable food and interactions with the owners or with other animals.
[89]
Rodent models
[
edit
]
Mice that are genetically engineered to lack orexin genes demonstrate many similarities to human narcolepsy. During nocturnal hours, when mice are normally present, those lacking orexin demonstrated
murine
cataplexy and displayed brain and muscle electrical activity similar to the activity present during REM and NREM sleep. This cataplexy is able to be triggered through social interaction, wheel running, and ultrasonic vocalizations. Upon awakening, the mice also display behavior consistent with excessive daytime sleepiness.
[90]
Mouse models have also been used to test whether the lack of orexin
neurons
is correlated with narcolepsy. Mice whose orexin neurons have been ablated have shown sleep fragmentation, SOREMPs, and obesity.
[90]
Rat models have been used to demonstrate the association between orexin deficiency and narcoleptic symptoms. Rats who lost the majority of their orexinergic neurons exhibited multiple SOREMPs as well as less wakefulness during nocturnal hours, shortened REM latency, and brief periods of cataplexy.
[90]
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