From Wikipedia, the free encyclopedia
American biochemist
John Kuriyan
is the dean of basic sciences and a professor of biochemistry at
Vanderbilt University School of Medicine
. He was formerly the Chancellor's Professor at the
University of California, Berkeley
in the departments of molecular and cell biology (MCB) and chemistry, a faculty scientist in
Berkeley Lab
's physical biosciences division, and a
Howard Hughes Medical Institute
investigator. He is a member of the
National Academy of Sciences
[1]
and he has also been on the Life Sciences jury for the
Infosys Prize
in 2009, 2019 and 2020.
[3]
Education
[
edit
]
Kuriyan received his B.S. in chemistry from
Juniata College
in Pennsylvania, followed by his PhD in physical chemistry at the
Massachusetts Institute of Technology
supervised by
Gregory Petsko
and
Martin Karplus
.
[4]
Research and career
[
edit
]
Kuriyan did
postdoctoral research
work for one year supervised by Karplus at
Harvard
before becoming an assistant professor at the
Rockefeller University
. As of 2015
[update]
Kuriyan's laboratory studies the structure and mechanism of enzymes and other proteins that transduce cellular signals and perform
DNA replication
. The laboratory primarily uses
x-ray crystallography
to determine 3-D protein structures as well as biochemical, biophysical, and computational techniques to uncover the mechanisms used by these proteins.
Awards and honors
[
edit
]
In 1989, Kuriyan was named a
Pew Scholar
in the Biomedical Sciences, and was the recipient of the 2005 Loundsbery Award by the
National Academy of Sciences
, .
[5]
He has also received the Cornelius Rhoads Memorial Award from the
American Association for Cancer Research
(1999),
[6]
the
Eli Lilly Award in Biological Chemistry
of the
American Chemical Society
(1998), the Dupont-Merck Award of the Protein Society (1997), and the Schering-Plough Award of the
American Society for Biochemistry and Molecular Biology
(1994). In 2009 he received the ASBMB Merck award for his contributions to structural biology. Kuriyan was elected a
Foreign Member of the Royal Society (ForMemRS) in 2015
.
[2]
He was elected to the
National Academy of Medicine
in 2018.
[7]
Books
[
edit
]
- The molecules of life: physical and chemical principles
with Konforti, Boyana; Wemmer, David (2013)
[8]
- Mechanisms of RAS activation at the membrane
(2006)
[9]
Publications
[
edit
]
- Crystallographic R factor refinement by molecular dynamics
[10]
- Structural mechanism for STI-571 inhibition of abelson tyrosine kinase
[11]
- Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia
- The conformational plasticity of protein kinases
- An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor
References
[
edit
]
- ^
a
b
"John Kuriyan"
.
www.nasonline.org
.
- ^
a
b
"John Kuriyan - Royal Society"
.
royalsociety.org
.
- ^
"Infosys Prize - Jury 2020"
.
www.infosys-science-foundation.com
. Retrieved
2020-12-10
.
- ^
Kuriyan, John (1986).
The structure and flexibility of myoglobin: molecular dynamics and x-ray crystallography
(Thesis).
OCLC
15862419
.
- ^
"Richard Lounsbery Award"
.
www.nasonline.org
. Retrieved
2020-02-08
.
- ^
Journal of the National Cancer Institute: JNCI
. U.S. Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health. May 1999. p. 830.
- ^
"National Academy of Medicine Elects 85 New Members"
.
National Academy of Medicine
. 15 October 2018
. Retrieved
2 May
2019
.
- ^
Kuriyan, John; Konforti, Boyana; Wemmer, David (2013).
The molecules of life: physical and chemical principles
.
ISBN
978-0-8153-4188-8
.
OCLC
779577263
.
- ^
Kuriyan, John; Harvard University; Department of Chemistry and Chemical Biology (2006),
Mechanisms of RAS activation at the membrane
,
OCLC
232369650
- ^
Brunger, Axel T.; Kuriyan, John; Karplus, Martin (1987-01-23). "Crystallographic R Factor Refinement by Molecular Dynamics".
Science
.
235
(4787): 458?460.
Bibcode
:
1987Sci...235..458B
.
doi
:
10.1126/science.235.4787.458
.
ISSN
0036-8075
.
PMID
17810339
.
S2CID
38261757
.
- ^
Schindler, T.; Bornmann, W.; Pellicena, P.; Miller, W. T.; Clarkson, B.; Kuriyan, J. (2000-09-15). "Structural mechanism for STI-571 inhibition of abelson tyrosine kinase".
Science
.
289
(5486): 1938?1942.
Bibcode
:
2000Sci...289.1938S
.
doi
:
10.1126/science.289.5486.1938
.
ISSN
0036-8075
.
PMID
10988075
.
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