IL1F10

IL1F10
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5BOW
Identifiers
Aliases	IL1F10 , FIL1-theta, IL-1HY2, IL-38, IL1-theta, IL1HY2, FKSG75, interleukin 1 family member 10 (theta), interleukin 1 family member 10
External IDs	OMIM : 615296 ; MGI : 2652548 ; HomoloGene : 17690 ; GeneCards : IL1F10 ; OMA : IL1F10 - orthologs
Gene location ( Human )
Chr.	Chromosome 2 (human)
End	113,075,843 bp
Gene location ( Mouse )
Chr.	Chromosome 2 (mouse)
End	24,183,832 bp
RNA expression pattern
	Top expressed in
	skin of limb ; ; skin of leg ; ; skin of abdomen ; ; skin of thigh ; ; human penis ; ; amniotic fluid ; ; gonad ; ; pharynx ; ; tonsil ; ; placenta ;
	Top expressed in
	lip ; ; skin of abdomen ; ; skin of external ear ; ; skin of back ; ; hair follicle ; ; cervix ; ; thymus ;
	More reference expression data
	n/a
Gene ontology
Molecular function	cytokine activity ; interleukin-1 receptor binding ;
Cellular component	extracellular space ; extracellular region ;
Biological process	inflammatory response ; immune response ; regulation of signaling receptor activity ; cytokine-mediated signaling pathway ; cellular response to cytokine stimulus ; neutrophil chemotaxis ; positive regulation of interleukin-6 production ; positive regulation of I-kappaB kinase/NF-kappaB signaling ; positive regulation of JNK cascade ; cellular response to lipopolysaccharide ;
	Sources: Amigo / QuickGO
Orthologs
	84639
	215274
	ENSG00000136697
	ENSMUSG00000046845
	Q8WWZ1
	Q8R459
	NM_173161 ; NM_032556
	NM_153077
	NP_115945 ; NP_775184
	NP_694717
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin-1 family member 10 is a protein that in humans is encoded by the IL1F10 gene . ^[5]^[6]^[7]^[8]

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. This cytokine is thought to participate in a network of interleukin 1 family members to regulate adapted and innate immune responses. Two alternatively spliced transcript variants encoding the same protein have been reported. ^[8]

References [ edit ]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000136697 – Ensembl , May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000046845 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Bensen JT, Dawson PA, Mychaleckyj JC, Bowden DW (Dec 2001). "Identification of a novel human cytokine gene in the interleukin gene cluster on chromosome 2q12-14". J Interferon Cytokine Res . 21 (11): 899?904. doi : 10.1089/107999001753289505 . PMID 11747621 .
^ Taylor SL, Renshaw BR, Garka KE, Smith DE, Sims JE (May 2002). "Genomic organization of the interleukin-1 locus". Genomics . 79 (5): 726?33. doi : 10.1006/geno.2002.6752 . PMID 11991723 .
^ Nicklin MJ, Barton JL, Nguyen M, FitzGerald MG, Duff GW, Kornman K (May 2002). "A sequence-based map of the nine genes of the human interleukin-1 cluster". Genomics . 79 (5): 718?25. doi : 10.1006/geno.2002.6751 . PMID 11991722 .
^ ^a ^b "Entrez Gene: IL1F10 interleukin 1 family, member 10 (theta)" .

Further reading [ edit ]

Nicklin MJ, Weith A, Duff GW (1994). "A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genes". Genomics . 19 (2): 382?4. doi : 10.1006/geno.1994.1076 . PMID 8188271 .
Nothwang HG, Strahm B, Denich D, et al. (1997). "Molecular cloning of the interleukin-1 gene cluster: construction of an integrated YAC/PAC contig and a partial transcriptional map in the region of chromosome 2q13". Genomics . 41 (3): 370?8. doi : 10.1006/geno.1997.4654 . PMID 9169134 .
Mulero JJ, Pace AM, Nelken ST, et al. (1999). "IL1HY1: A novel interleukin-1 receptor antagonist gene". Biochem. Biophys. Res. Commun . 263 (3): 702?6. doi : 10.1006/bbrc.1999.1440 . PMID 10512743 .
Smith DE, Renshaw BR, Ketchem RR, et al. (2000). "Four new members expand the interleukin-1 superfamily" . J. Biol. Chem . 275 (2): 1169?75. doi : 10.1074/jbc.275.2.1169 . PMID 10625660 .
Kumar S, McDonnell PC, Lehr R, et al. (2000). "Identification and initial characterization of four novel members of the interleukin-1 family" . J. Biol. Chem . 275 (14): 10308?14. doi : 10.1074/jbc.275.14.10308 . PMID 10744718 .
Busfield SJ, Comrack CA, Yu G, et al. (2000). "Identification and gene organization of three novel members of the IL-1 family on human chromosome 2". Genomics . 66 (2): 213?6. doi : 10.1006/geno.2000.6184 . PMID 10860666 .
Barton JL, Herbst R, Bosisio D, et al. (2001). "A tissue specific IL-1 receptor antagonist homolog from the IL-1 cluster lacks IL-1, IL-1ra, IL-18 and IL-18 antagonist activities" . Eur. J. Immunol . 30 (11): 3299?308. doi : 10.1002/1521-4141(200011)30:11<3299::AID-IMMU3299>3.0.CO;2-S . PMID 11093146 .
Pan G, Risser P, Mao W, et al. (2001). "IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1Rrp". Cytokine . 13 (1): 1?7. doi : 10.1006/cyto.2000.0799 . PMID 11145836 .
Lin H, Ho AS, Haley-Vicente D, et al. (2001). "Cloning and characterization of IL-1HY2, a novel interleukin-1 family member" . J. Biol. Chem . 276 (23): 20597?602. doi : 10.1074/jbc.M010095200 . PMID 11278614 .
Debets R, Timans JC, Homey B, et al. (2001). "Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2". Journal of Immunology . 167 (3): 1440?6. doi : 10.4049/jimmunol.167.3.1440 . PMID 11466363 . S2CID 85986577 .
Sims JE, Nicklin MJ, Bazan JF, et al. (2001). "A new nomenclature for IL-1-family genes". Trends Immunol . 22 (10): 536?7. doi : 10.1016/S1471-4906(01)02040-3 . PMID 11574262 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899?903. Bibcode : 2002PNAS...9916899M . doi : 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment" . Genome Res . 13 (10): 2265?70. doi : 10.1101/gr.1293003 . PMC 403697 . PMID 12975309 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121?7. doi : 10.1101/gr.2596504 . PMC 528928 . PMID 15489334 .
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4" . Nature . 434 (7034): 724?31. Bibcode : 2005Natur.434..724H . doi : 10.1038/nature03466 . PMID 15815621 .

This article on a gene on human chromosome 2 is a stub . You can help Wikipedia by expanding it .

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000136697 – Ensembl , May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000046845 – Ensembl , May 2017

[3] "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[4] "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[pmid11747621-5] Bensen JT, Dawson PA, Mychaleckyj JC, Bowden DW (Dec 2001). "Identification of a novel human cytokine gene in the interleukin gene cluster on chromosome 2q12-14". J Interferon Cytokine Res . 21 (11): 899?904. doi : 10.1089/107999001753289505 . PMID 11747621 .

[pmid11991723-6] Taylor SL, Renshaw BR, Garka KE, Smith DE, Sims JE (May 2002). "Genomic organization of the interleukin-1 locus". Genomics . 79 (5): 726?33. doi : 10.1006/geno.2002.6752 . PMID 11991723 .

[pmid11991722-7] Nicklin MJ, Barton JL, Nguyen M, FitzGerald MG, Duff GW, Kornman K (May 2002). "A sequence-based map of the nine genes of the human interleukin-1 cluster". Genomics . 79 (5): 718?25. doi : 10.1006/geno.2002.6751 . PMID 11991722 .

[entrez-8] "Entrez Gene: IL1F10 interleukin 1 family, member 10 (theta)" .

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