Doravirine

Clinical data
Trade names	Pifeltro
Other names	MK-1439
AHFS / Drugs.com	Monograph
MedlinePlus	a618048
License data	US   DailyMed :  Doravirine
Routes of administration	By mouth [1] [2]
ATC code	J05AG06 ( WHO )
Legal status
Legal status	AU : S4 (Prescription only) CA : ?-only [3] [4] UK : POM (Prescription only) [5] US : ?-only [1] EU : Rx-only [6]
Identifiers
IUPAC name 3-Chloro-5-({1-[(4-methyl-5-oxo-4,5-dihydro-1 H -1,2,4-triazol-3-yl)methyl]-2-oxo-4-(trifluoromethyl)-1,2-dihydro-3-pyridinyl}oxy)benzonitrile
CAS Number	1338225-97-0
PubChem CID	58460047
DrugBank	DB12301
ChemSpider	28424197
UNII	913P6LK81M
KEGG	D10624
ChEMBL	ChEMBL2364608
PDB ligand	2KW ( PDBe , RCSB PDB )
CompTox Dashboard ( EPA )	DTXSID30158386
ECHA InfoCard	100.234.454
Chemical and physical data
Formula	C 17 H 11 Cl F 3 N 5 O 3
Molar mass	425.75  g·mol ?1
3D model ( JSmol )	Interactive image
SMILES Cn1c(n[nH]c1=O)Cn2ccc(c(c2=O)Oc3cc(cc(c3)Cl)C#N)C(F)(F)F
InChI InChI=1S/C17H11ClF3N5O3/c1-25-13(23-24-16(25)28)8-26-3-2-12(17(19,20)21)14(15(26)27)29-11-5-9(7-22)4-10(18)6-11/h2-6H,8H2,1H3,(H,24,28) Key:ZIAOVIPSKUPPQW-UHFFFAOYSA-N

Doravirine , sold under the brand name Pifeltro , is a non-nucleoside reverse transcriptase inhibitor medication developed by Merck & Co. for use in the treatment of HIV/AIDS .

Doravirine was approved for medical use in the United States in August 2018. ^[7]

Doravirine is available in fixed-dose combinations with other HIV drugs such as doravirine/lamivudine/tenofovir (sold under the brand name Delstrigo). ^[8]

References [ edit ]

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