American cancer biologist and neurobiologist
Don W. Cleveland
(born 1950 in
Waynesville, MO
) is an American cancer
biologist
and
neurobiologist
.
Cleveland is currently the Department Chair of Cellular and Molecular Medicine
[1]
and Distinguished Professor of Medicine, Cellular and Molecular Medicine and Neurosciences
[2]
at the
University of California at San Diego
, and Head, Laboratory for Cell Biology at the San Diego branch of
Ludwig Cancer Research
.
[3]
Biography
[
edit
]
Cleveland grew up in Las Cruces, New Mexico. He earned a B.S. in physics in 1972 from
New Mexico State University
, and graduated as the valedictorian for the College of Arts and Sciences.
[3]
Cleveland started graduate school at
Princeton University
in 1972, switching mid-year into biochemistry. He worked with
Marc Kirschner
and graduated with a Ph.D. in 1977. Cleveland's doctoral dissertation was titled "Purification and properties of tau, a microtubule associated protein which induces assembly of microtubules from purified tubulin".
[4]
As a graduate student, Cleveland provided the initial identification and characterization of
tau
, showing it to have characteristics of a natively unfolded protein.
[5]
Tau is now recognized to accumulate in Alzheimer's disease and to be the basis for chronic brain injury.
[6]
He also developed and published a peptide fingerprinting technique
[7]
that was so popular that it became a citation classic
[8]
Cleveland did postdoctoral work with
William J. Rutter
at the
University of California at San Francisco
from 1978 to 1981. Cleveland was the first to clone
tubulin
[9]
[10]
actin
and
keratin
[11]
From 1981 through 1995, Cleveland was on the faculty of the Department of Biological Chemistry at the
Johns Hopkins University School of Medicine
. In 1995, he accepted a position at the San Diego Branch of Ludwig Cancer Research at the
University of California at San Diego
. Since 2008, he has been Chair of the Department of Cellular and Molecular Medicine.
Contributions to Science
[
edit
]
Cleveland has made pioneering discoveries of the mechanisms of chromosome movement and cell-cycle control during normal cellular division, as well as of the principles of neuronal cell development and their relationship to the defects that contribute to inherited neurodegenerative disease.
[12]
Cleveland's research looks at the molecular genetics of axonal growth and motor neuron disease and the cell biology of mammalian chromosome movement.
[13]
Most recently, his research has achieved a significant breakthrough in treating Huntington's disease, an inherited and degenerative brain disorder for which there is no cure. A one-time injection of a new DNA-based drug treatment - known as ASO (short for antisense oligonucleotide) - blocked the activity of the gene whose mutation causes the disease. A single treatment silenced the mutated gene responsible for the disease, slowing and partially reversing progression of the fatal neurodegenerative disorder in animal models.
[14]
This drug, called IONIS-HTTRx, was developed by scientists at Ionis Pharmaceuticals in collaboration with partners CHDI Foundation, Roche Pharmaceuticals and academic collaborators at University of California, San Diego and is now in a Phase 1/2a clinical study.
[15]
Books
[
edit
]
Cell and Molecular Biology of the Cytoskeleton: Molecular Mechanisms Controlling Tubulin Synthesis
Edited by Jerry W. Shay
(Plenum Press, 1986),
ISBN
978-1-4612-9269-2
With Toni L. Williamson,
Mouse Models in the Study of Genetic Neurological Disorders: Mouse Models of Amyotrophic Lateral Sclerosis
Edited by Brian Popko
(Kluwer Academic/Plenum Publishers, 1999),
ISBN
0-306-45965-5
With Nicholas G. Theodorakis,
Control of Messenger RNA Stability: Translationally Coupled Degradation of Tubulin mRNA
Edited by Joel Belasco and George Brawerman
(Academic Press, Inc., 1993)
ISBN
0-12-084782-5
Select honors
[
edit
]
- Elected Member,
National Academy of Sciences
, 2006
[16]
- Elected Member, Institute of Medicine (IOM), 2012
[17]
- Elected Fellow,
American Academy of Arts and Sciences
, 2006
[18]
- Elected Fellow,
American Academy of Microbiology
, 2006
[19]
[20]
- Elected Fellow,
American Association for the Advancement of Science
(AAAS), 2009
[21]
- President,
American Society for Cell Biology
, 2013
[22]
- Sheila Essey Prize,
American Academy of Neurology
, April 1999
[23]
- Outstanding Scientist Award, Playing to Win for Life Foundation, September 2004
- Wings Over Wall Street and MDA Outstanding Scientist, October 2007
[24]
- 2012 Research Award, The Huntington's Disease Society of America
- Katharine Berkan Judd Award,
Memorial Sloan Kettering
, 2012
[25]
- The Ricketts Award, University of Chicago, 2012
- The Gerson Distinguished Scholar Award, Univ. of Pittsburgh, 2014
- Essey Prize for ALS Research,
The ALS Association
, 2014
[26]
- UCSD Chancellor's Award for Excellence in Postdoctoral Scholar Mentoring, 2014
[27]
- Thomas Reuters' 2015 listing of "The World's Most Influential Scientific Minds" 2015
[28]
- Breakthrough Prize in Life Sciences
, 2018
[29]
- NOMIS Distinguished Scientist Awardee, 2018
[30]
- ASCB E.B. Wilson Medal, 2022
[31]
References
[
edit
]
- ^
"Don Cleveland Named New Chair Cellular and Molecular Medicine at UC San Diego School of Medicine"
. Debra Kain
. Retrieved
December 15,
2008
.
- ^
"Four Department of Medicine Faculty Members Are on 2015 Thomson Reuters Highly Cited Researchers List"
.
News From The Department of Medicine
. Regents of the University of California. Archived from
the original
on January 24, 2017
. Retrieved
February 2,
2016
.
- ^
a
b
"DON CLEVELAND LAB"
.
DON CLEVELAND LAB
. LUDWIG INSTITUTE FOR CANCER RESEARCH LTD. Archived from
the original
on December 12, 2018
. Retrieved
September 28,
2015
.
- ^
Cleveland, Don W. (1977).
Purification and properties of tau, a microtubule associated protein which induces assembly of microtubules from purified tubulin
.
- ^
Mandelkow, E.-M.; Mandelkow, E. (March 20, 2012).
"Biochemistry and Cell Biology of Tau Protein in Neurofibrillary Degeneration"
(PDF)
.
Cold Spring Harbor Perspectives in Medicine
.
2
(7): a006247.
doi
:
10.1101/cshperspect.a006247
.
PMC
3385935
.
PMID
22762014
.
- ^
McKee; et al. (2009).
"Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury"
.
J Neuropathol Exp Neurol
.
68
(7): 709?35.
doi
:
10.1097/NEN.0b013e3181a9d503
.
PMC
2945234
.
PMID
19535999
.
- ^
Cleveland, D.W.; Fischer, S.G.; Kirschner, M.W. & Laemmli, U.K. (1977).
"Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis"
(PDF)
.
J. Biol. Chem
.
252
(3): 1102?6.
doi
:
10.1016/S0021-9258(19)75212-0
.
PMID
320200
.
- ^
Kresge, Nicole; Simoni, Robert D.; Hill, Robert L. (August 18, 2006).
"The Development of Cleveland Peptide Mapping by Don W. Cleveland"
.
The Journal of Biological Chemistry
.
281
(33): e27.
doi
:
10.1016/S0021-9258(19)46364-3
.
- ^
Janke, Carsten (August 18, 2014).
"The tubulin code: Molecular components, readout mechanisms, and functions"
.
The Journal of Cell Biology
.
206
(4): 461?472.
doi
:
10.1083/jcb.201406055
.
PMC
4137062
.
PMID
25135932
.
- ^
Cleveland, Don W.; Lopata, Margaret A.; MacDonald, Raymond J.; Cowan, Nicholas J.; Rutter, William J.; Kirschner, Marc (May 1980).
"Number and evolutionary conservation of alpha- and beta-tubulin and cytoplasmic beta- and gamma-actin genes using specific cloned cDNA probes"
(PDF)
.
Cell
.
20
(1): 95?105.
doi
:
10.1016/0092-8674(80)90238-x
.
PMID
6893015
.
S2CID
54326866
.
- ^
Fuchs, Elaine V.; Coppock, Susan M.; Green, Howard; Cleveland, Don W. (November 1981).
"Two distinct classes of keratin genes and their evolutionary significance"
(PDF)
.
Cell
.
27
(1): 75?84.
doi
:
10.1016/0092-8674(81)90362-7
.
PMID
6173133
.
S2CID
38166670
.
- ^
"Dr. Don Cleveland of Ludwig Institute for Cancer Research elected to Institute of Medicine"
.
EurekAlert!
. American Association for the Advancement of Science (AAAS).
- ^
"UC San Diego Researchers Cited Among "World's Most Influential Scientific Minds"
"
.
UC San Diego News Center
. UC San Diego.
- ^
"Potential treatment for Huntington's disease, found effective, safe in mice, monkeys"
.
EurekAlert!
. American Association for the Advancement of Science (AAAS).
- ^
"Huntington's Drug That Silences Gene at Root of Disease Now in Phase 1 Clinical Test"
.
Huntington's Disease News
. BioNews Services LLC.
- ^
"UCSD Faculty Members of the National Academy of Sciences"
. UC San Diego.
- ^
"Two from UCSD School of Medicine Named Members of the Institute of Medicine"
.
- ^
American Academy of Arts & Sciences.
"Six UCSD scholars elected fellows of American Academy of Arts and Sciences"
.
- ^
"ASM Society Directory"
. American Society for Microbiology. Archived from
the original
on May 25, 2017
. Retrieved
September 23,
2015
.
- ^
"ASM Members Elected to National Academy of Sciences"
(PDF)
. American Society for Microbiology. Archived from
the original
(PDF)
on January 24, 2017
. Retrieved
April 12,
2016
.
- ^
"AAAS Members Elected as Fellows"
. December 18, 2009.
- ^
"President's Column"
(PDF)
.
The American Society for Cell Biology
.
- ^
"The Sheila Essey Award for ALS Research"
.
- ^
"Wings Over Wall Street Diamond Award"
.
- ^
"2012 Commencement and Academic Convocation"
. June 13, 2012.
- ^
"A Night at the Esseys"
. June 5, 2014.
- ^
"Excellence in Postdoctoral Scholar Mentoring and Postdoctoral Scholar Awards"
. September 18, 2014.
- ^
"Ludwig scientists named to Thomson Reuters' list of world's most influential scientific minds"
.
Ludwig Cancer Research
. 2016 LUDWIG INSTITUTE FOR CANCER RESEARCH LTD
. Retrieved
October 30,
2018
.
- ^
"Breakthrough Prize ? Life Sciences Breakthrough Prize ? Laureates"
.
breakthroughprize.org
. Retrieved
December 13,
2021
.
- ^
Foundation, Nomis.
"Don W. Cleveland, NOMIS Distinguished Scientist Awardee 2018"
.
Nomis Foundation
. 2016 The NOMIS Foundation, Zurich, Switzerland
. Retrieved
October 30,
2018
.
- ^
"American Society for Cell Biology announces 2022 honorific awards and recognition"
.
External links
[
edit
]
|
---|
Mathematics
| |
---|
Fundamental
physics
|
- Nima Arkani-Hamed
,
Alan Guth
,
Alexei Kitaev
,
Maxim Kontsevich
,
Andrei Linde
,
Juan Maldacena
,
Nathan Seiberg
,
Ashoke Sen
,
Edward Witten
(2012)
- Special
:
Stephen Hawking
,
Peter Jenni
,
Fabiola Gianotti
(ATLAS),
Michel Della Negra
,
Tejinder Virdee
,
Guido Tonelli
,
Joseph Incandela
(CMS) and
Lyn Evans
(LHC) (2013)
- Alexander Polyakov
(2013)
- Michael Green
and
John Henry Schwarz
(2014)
- Saul Perlmutter
and members of the
Supernova Cosmology Project
;
Brian Schmidt
,
Adam Riess
and members of the
High-Z Supernova Team
(2015)
- Special
:
Ronald Drever
,
Kip Thorne
,
Rainer Weiss
and contributors to
LIGO
project (2016)
- Yifang Wang
,
Kam-Biu Luk
and the
Daya Bay team
,
Atsuto Suzuki
and the
KamLAND
team,
K?ichir? Nishikawa
and the
K2K
/
T2K
team,
Arthur B. McDonald
and the
Sudbury Neutrino Observatory
team,
Takaaki Kajita
and
Y?ichir? Suzuki
and the
Super-Kamiokande
team (2016)
- Joseph Polchinski
,
Andrew Strominger
,
Cumrun Vafa
(2017)
- Charles L. Bennett
,
Gary Hinshaw
,
Norman Jarosik
,
Lyman Page Jr.
,
David Spergel
(2018)
- Special
:
Jocelyn Bell Burnell
(2018)
- Charles Kane
and
Eugene Mele
(2019)
- Special
:
Sergio Ferrara
,
Daniel Z. Freedman
,
Peter van Nieuwenhuizen
(2019)
- The Event Horizon Telescope Collaboration
(2020)
- Eric Adelberger
,
Jens H. Gundlach
and
Blayne Heckel
(2021)
- Special
:
Steven Weinberg
(2021)
- Hidetoshi Katori
and
Jun Ye
(2022)
- Charles H. Bennett
,
Gilles Brassard
,
David Deutsch
,
Peter W. Shor
(2023)
- John Cardy
and
Alexander Zamolodchikov
(2024)
|
---|
Life sciences
|
- Cornelia Bargmann
,
David Botstein
,
Lewis C. Cantley
,
Hans Clevers
,
Titia de Lange
,
Napoleone Ferrara
,
Eric Lander
,
Charles Sawyers
,
Robert Weinberg
,
Shinya Yamanaka
and
Bert Vogelstein
(2013)
- James P. Allison
,
Mahlon DeLong
,
Michael N. Hall
,
Robert S. Langer
,
Richard P. Lifton
and
Alexander Varshavsky
(2014)
- Alim Louis Benabid
,
Charles David Allis
,
Victor Ambros
,
Gary Ruvkun
,
Jennifer Doudna
and
Emmanuelle Charpentier
(2015)
- Edward Boyden
,
Karl Deisseroth
,
John Hardy
,
Helen Hobbs
and
Svante Paabo
(2016)
- Stephen J. Elledge
,
Harry F. Noller
,
Roeland Nusse
,
Yoshinori Ohsumi
,
Huda Zoghbi
(2017)
- Joanne Chory
,
Peter Walter
,
Kazutoshi Mori
,
Kim Nasmyth
,
Don W. Cleveland
(2018)
- C. Frank Bennett
and
Adrian R. Krainer
,
Angelika Amon
,
Xiaowei Zhuang
,
Zhijian Chen
(2019)
- Jeffrey M. Friedman
,
Franz-Ulrich Hartl
,
Arthur L. Horwich
,
David Julius
,
Virginia Man-Yee Lee
(2020)
- David Baker
,
Catherine Dulac
,
Dennis Lo
,
Richard J. Youle
[
de
]
(2021)
- Jeffery W. Kelly
,
Katalin Kariko
,
Drew Weissman
,
Shankar Balasubramanian
,
David Klenerman
and
Pascal Mayer
(2022)
- Clifford P. Brangwynne
,
Anthony A. Hyman
,
Demis Hassabis
,
John Jumper
,
Emmanuel Mignot
,
Masashi Yanagisawa
(2023)
- Carl June
,
Michel Sadelain
,
Sabine Hadida
,
Paul Negulescu
,
Fredrick Van Goor
,
Thomas Gasser
,
Ellen Sidransky
and
Andrew Singleton
(2024)
|
---|
|
---|
International
| |
---|
National
| |
---|
Academics
| |
---|
People
| |
---|
Other
| |
---|