From Wikipedia, the free encyclopedia
Chemical compound
Acetylpyrazine
is an
organic compound
with the
chemical formula
C
6
H
6
N
2
O
. It is a yellow-brown powder at room temperature.
[1]
Chemically, acetylpyrazine is a
pyrazine
and a
ketone
.
[2]
Natural occurrence
[
edit
]
Acetylpyrazine is found in foods such as
seeds
,
nuts
and
meats
.
Uses
[
edit
]
It is used in frozen dairy products such as
ice cream
.
It is considered
generally recognized as safe
by the
U.S. Food and Drug Administration
.
[3]
"Essence formula for increasing cigarette fragrance and improving smoke quality".
[4]
It is also known to be part of the formulation of e-cigarettes (vapes):
[5]
Synthesis
[
edit
]
Note that modern synthesis is for 2-cyanopyrazine from
2-methylpyrazine
[109-08-0].
[6]
[7]
Pyrazinamide
[98-96-4] (
1
)
2-Cyanopyrazine [19847-12-2] (
2
)
More modern syntheses have also been reported in recent years:
[10]
[11]
[12]
References
[
edit
]
- ^
a
b
Acetylpyrazine on Chemical Book
- ^
a
b
Acetylpyrazine on Sigma Aldrich
- ^
Martin, Terry (8 Feb 2004).
"Acetylpyrazine"
. About.com Smoking Cessation. Archived from
the original
on 6 January 2016
. Retrieved
16 June
2014
.
- ^
Mao Deshou, et al. CN115216363 (2022 to China Tobacco Yunnan Industrial Co Ltd).
- ^
National Academies of Sciences, Engineering, and Medicine; Health And Medicine, Division; Board on Population Health and Public Health Practice; Committee on the Review of the Health Effects of Electronic Nicotine Delivery Systems; Eaton, D. L.; Kwan, L. Y.; Stratton, K. (2018). Stratton, Kathleen; Kwan, Leslie Y.; Eaton, David L. (eds.).
Public Health Consequences of E-Cigarettes
.
doi
:
10.17226/24952
.
ISBN
978-0-309-46834-3
.
PMID
29894118
.
CS1 maint: multiple names: authors list (
link
)
- ^
Rao, K. Narasimha; Gopinath, Rajesh; Prasad, P. S. Sai (2001). "Highly selective molybdenum phosphate catalyst for the ammoxidation of 2-methylpyrazine to 2-cyanopyrazine".
Green Chemistry
.
3
(1): 20?22.
doi
:
10.1039/b005643j
.
- ^
Hong, Chun; Li, Yong (2006). "2-Cyanopyrazine Prepared from 2-Methylpyrazine by Catalytic Ammoxidation on MoVPO Catalyst".
Chinese Journal of Chemical Engineering
.
14
(5): 670?675.
doi
:
10.1016/S1004-9541(06)60133-X
.
- ^
Donald L Roberts,
U.S. patent 3,402,051
(1968 to RJ Reynolds Tobacco Co).
- ^
Jr Victor K Smith & Kushner Samuel,
U.S. patent 2,677,686
(1954 to Wyeth Holdings LLC).
- ^
Mao, Lin; Niu, Dong-Fang; Hu, Shuo-Zhen; Zhang, Xin-Sheng (2022-05-28). "Electrochemical Synthesis of Acetylpyrazine".
Journal of Electrochemistry
.
28
(5): 2107061.
doi
:
10.13208/j.electrochem.210706
.
- ^
Wang et al.:
Progress in the Synthesis and Application of Acetylpyrazine
, 2011.
- ^
任?, et al. CN106588785 (2017 to Yoshida Spice Ltd By Share Ltd Shandong).