PKIA

PKIA
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??? ?????? ????????	Ortholog search: PDBe RCSB
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	1CMK , 1JLU , 1Q8T , 1XH4 , 1XH5 , 1XH6 , 1XH7 , 1XH8 , 1XH9 , 1XHA , 1YDR , 2C1A , 2C1B , 2F7E , 2GNI , 2JDS , 2JDT , 2JDV , 2L1L , 2UVY , 2UVZ , 2UW0 , 2UW3 , 2UW4 , 2UW5 , 2UW6 , 2UW7 , 2UW8 , 2VNW , 2VNY , 2VO0 , 2VO3 , 2VO6 , 2VO7 , 3AMA , 3AMB , 3L9L , 3L9M , 3L9N , 3MVJ , 3NX8 , 3OOG , 3OVV , 3OWP , 3OXT , 3P0M , 3POO , 3VQH , 3WYG , 4AXA , 4IAC , 4IAD , 4IAF , 4IAI , 4IAK , 4IAY , 4IAZ , 4IB0 , 4IB1 , 4IB3 , 4IE9 , 4IJ9 , 4O21 , 4O22 , 4WB5 , 4WB6 , 4WB7 , 4WB8 , 4Z83 , 4Z84 , 5DH9 , 1Q61 , 3X2U , 3X2W , 1Q62 , 3X2V , 4UJA , 4UJ9 , 4UJB , 4UJ2 , 4UJ1
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????? ?????	PKIA , PRKACN1, protein kinase (cAMP-dependent, catalytic) inhibitor alpha, cAMP-dependent protein kinase inhibitor alpha
?????? ??????	??????? ???????? ??????? ??? ???????? 606059 MGI: MGI:104747 HomoloGene: 7473 GeneCards: 5569
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????? ??????	? protein kinase inhibitor activity ; ? ?GO:0001948? ?GO:0016582 ??? ??????? ; ? cAMP-dependent protein kinase inhibitor activity ; ? protein kinase A catalytic subunit binding ; ? kinase activity ;
?????? ?????	? ????????? ; ? ???? ;
?????? ?????	? regulation of G2/M transition of mitotic cell cycle ; ? ?GO:0048553 negative regulation of catalytic activity ; ? ?GO:1901227 negative regulation of transcription by RNA polymerase II ; ? negative regulation of cAMP-dependent protein kinase activity ; ? negative regulation of protein kinase activity ; ? negative regulation of protein import into nucleus ; ? negative regulation of protein serine/threonine kinase activity ; ? ????? ;
	???????: Amigo / QuickGO
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	P61925 ; A0A024R7Y9
	P63248
	?NM_006823? ?XM_017013620? ?XM_017013621? ?XM_017013622? ?XM_047421953 NM_181839? ?NM_006823? ?XM_017013620? ?XM_017013621? ?XM_017013622? ?XM_047421953
	?XM_006530056? ?XM_036162941? ?XM_036162942 NM_008862? ?XM_006530056? ?XM_036162941? ?XM_036162942
	?NP_862822? ?XP_016869109? ?XP_016869110? ?XP_016869111 NP_006814? ?NP_862822? ?XP_016869109? ?XP_016869110? ?XP_016869111 ; ?NP_862822.1 NP_006814.1? ?NP_862822.1
	?XP_006530119? ?XP_036018834? ?XP_036018835 NP_032888? ?XP_006530119? ?XP_036018834? ?XP_036018835
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PKIA ? ( CAMP-dependent protein kinase inhibitor alpha ) ??? ?????? ?????? ?????? ??? PKIA ?? ??????? . ^[1]^[2]

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^ Olsen SR? Uhler MD (?????? 1992). "Inhibition of protein kinase-A by overexpression of the cloned human protein kinase inhibitor". Mol Endocrinol . ?. 5 ?. 9: 1246?56. DOI : 10.1210/mend-5-9-1246 . PMID : 1770951 .
^ "Entrez Gene: PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha" . ????? ?? ????? ?? 2010-12-05.

????? ?????? [ ??? ]

Olsen SR? Uhler MD (1991). "Isolation and characterization of cDNA clones for an inhibitor protein of cAMP-dependent protein kinase". J. Biol. Chem . ?. 266 ?. 17: 11158?62. PMID : 1710219 .
Knighton DR? Zheng JH? Ten Eyck LF? ?????? (1991). "Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase". Science . ?. 253 ?. 5018: 414?20. DOI : 10.1126/science.1862343 . PMID : 1862343 .
Van Patten SM? Heisermann GJ? Cheng HC? Walsh DA (1987). "Tyrosine kinase catalyzed phosphorylation and inactivation of the inhibitor protein of the cAMP-dependent protein kinase". J. Biol. Chem . ?. 262 ?. 7: 3398?403. PMID : 2434500 .
Scott JD? Fischer EH? Demaille JG? Krebs EG (1985). "Identification of an inhibitory region of the heat-stable protein inhibitor of the cAMP-dependent protein kinase" . Proc. Natl. Acad. Sci. U.S.A . ?. 82 ?. 13: 4379?83. DOI : 10.1073/pnas.82.13.4379 . PMC : 390417 . PMID : 2989819 .
Scott JD? Glaccum MB? Fischer EH? Krebs EG (1986). "Primary-structure requirements for inhibition by the heat-stable inhibitor of the cAMP-dependent protein kinase" . Proc. Natl. Acad. Sci. U.S.A . ?. 83 ?. 6: 1613?6. DOI : 10.1073/pnas.83.6.1613 . PMC : 323133 . PMID : 3456605 .
Wen W? Taylor SS? Meinkoth JL (1995). "The expression and intracellular distribution of the heat-stable protein kinase inhibitor is cell cycle regulated". J. Biol. Chem . ?. 270 ?. 5: 2041?6. DOI : 10.1074/jbc.270.5.2041 . PMID : 7836431 . {{ ??????? ?????? ????? }}: ????? ?????????: ??? ????? ??? ???? ( link )
Baude EJ? Dignam SS? Olsen SR? ?????? (1994). "Glutamic acid 203 of the cAMP-dependent protein kinase catalytic subunit participates in the inhibition by two isoforms of the protein kinase inhibitor". J. Biol. Chem . ?. 269 ?. 3: 2316?23. PMID : 7905001 .
Baude EJ? Dignam SS? Reimann EM? Uhler MD (1994). "Evidence for the importance of hydrophobic residues in the interactions between the cAMP-dependent protein kinase catalytic subunit and the protein kinase inhibitors". J. Biol. Chem . ?. 269 ?. 27: 18128?33. PMID : 8027074 .
Fritz CC? Green MR (1997). "HIV Rev uses a conserved cellular protein export pathway for the nucleocytoplasmic transport of viral RNAs". Curr. Biol . ?. 6 ?. 7: 848?54. DOI : 10.1016/S0960-9822(02)00608-5 . PMID : 8805303 .
Zimmermann B? Chiorini JA? Ma Y? ?????? (1999). "PrKX is a novel catalytic subunit of the cAMP-dependent protein kinase regulated by the regulatory subunit type I". J. Biol. Chem . ?. 274 ?. 9: 5370?8. DOI : 10.1074/jbc.274.9.5370 . PMID : 10026146 . {{ ??????? ?????? ????? }}: ????? ?????????: ??? ????? ??? ???? ( link )
Yu J? Yu L? Chen Z? ?????? (2002). "Protein inhibitor of neuronal nitric oxide synthase interacts with protein kinase A inhibitors". Brain Res. Mol. Brain Res . ?. 99 ?. 2: 145?9. DOI : 10.1016/S0169-328X(02)00104-3 . PMID : 11978406 .
Strausberg RL? Feingold EA? Grouse LH? ?????? (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . ?. 99 ?. 26: 16899?903. DOI : 10.1073/pnas.242603899 . PMC : 139241 . PMID : 12477932 .
Gassel M? Breitenlechner CB? Ruger P? ?????? (2003). "Mutants of protein kinase A that mimic the ATP-binding site of protein kinase B (AKT)". J. Mol. Biol . ?. 329 ?. 5: 1021?34. DOI : 10.1016/S0022-2836(03)00518-7 . PMID : 12798691 .
Gerhard DS? Wagner L? Feingold EA? ?????? (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . ?. 14 ?. 10B: 2121?7. DOI : 10.1101/gr.2596504 . PMC : 528928 . PMID : 15489334 .

??? ???? ????? ?? ??? ??? ???????? 8 ????? ???????. ????? ???? ?? ???????.

[1] Olsen SR? Uhler MD (?????? 1992). "Inhibition of protein kinase-A by overexpression of the cloned human protein kinase inhibitor". Mol Endocrinol . ?. 5 ?. 9: 1246?56. DOI : 10.1210/mend-5-9-1246 . PMID : 1770951 .

[2] "Entrez Gene: PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha" . ????? ?? ????? ?? 2010-12-05.

[1]

[2]

????????? ??????	???? ??????? ???????? ??? ????? (OMIM) : 606059
???????? ????????	Ensembl Transcript ID : ENST00000396418 ???? ????? ?????? ??????? (UMLS CUI) : C1418606