LEKTI

SPINK5
??? ??????
??? ?????? ????????	Ortholog search: PDBe RCSB
????? ???? ?????? ??? ?????? ????????
	1H0Z , 1HDL , 1UUC , 1UVF , 1UVG
??????
????? ?????	SPINK5 , LEKTI, LETKI, NETS, NS, VAKTI, serine peptidase inhibitor, Kazal type 5, serine peptidase inhibitor Kazal type 5
?????? ??????	??????? ???????? ??????? ??? ???????? 605010 MGI: MGI:1919682 HomoloGene: 4987 GeneCards: 11005
??? ?????? ??????
????? ??????	? peptidase inhibitor activity ; ? serine-type endopeptidase inhibitor activity ;
?????? ?????	? ????????? ; ? ????? ????? ; ? endoplasmic reticulum membrane ; ? ???? ?????? ; ? ???? ??????????? ; ? perinuclear region of cytoplasm ; ? epidermal lamellar body ; ? ?????? ???? ?????? ; ? intracellular membrane-bounded organelle ;
?????? ?????	? epidermal cell differentiation ; ? negative regulation of proteolysis ; ? negative regulation of serine-type peptidase activity ; ? negative regulation of peptidase activity ; ? epithelial cell differentiation ; ? hair cell differentiation ; ? extracellular matrix organization ; ? negative regulation of antibacterial peptide production ; ? negative regulation of immune response ; ? regulation of cell adhesion ; ? negative regulation of angiogenesis ; ? negative regulation of serine-type endopeptidase activity ; ? regulation of T cell differentiation ; ? cornification ; ? regulation of timing of anagen ;
	???????: Amigo / QuickGO
??? ??????? ?? ????? ?????? ????????
	?????? ?? ?????? ??????? ????????
??????? ???????
	Q9NQ38
	Q148R4
	?NM_001127698? ?NM_001127699? ?NM_006846? ?XM_047416662? ?XM_047416663 XM_011537551? ?NM_001127698? ?NM_001127699? ?NM_006846? ?XM_047416662? ?XM_047416663
	?XM_006526279? ?XM_006526280 NM_001081180? ?XM_006526279? ?XM_006526280
	?NP_001121171? ?NP_006837? ?XP_011535853 NP_001121170? ?NP_001121171? ?NP_006837? ?XP_011535853
	?XP_006526342? ?XP_006526343 NP_001074649? ?XP_006526342? ?XP_006526343
	???? ??????
????/???? ?????	????/???? ???

LEKTI ? ( Serine peptidase inhibitor, Kazal type 5 ) ??? ?????? ?????? ?????? ??? LEKTI ?? ??????? . ^[1]^[2]

????? ????? ????? ?????? ?? ????? ???? ??????? ??????? .

??????? [ ??? ]

??????? ???????? [ ??? ]

??????? [ ??? ]

^ "Entrez Gene: SPINK5 serine peptidase inhibitor, Kazal type 5" . ????? ?? ????? ?? 2010-12-05.
^ Magert HJ? Standker L? Kreutzmann P? Zucht HD? Reinecke M? Sommerhoff CP? Fritz H? Forssmann WG (????? 1999). "LEKTI, a novel 15-domain type of human serine proteinase inhibitor". J Biol Chem . ?. 274 ?. 31: 21499?502. DOI : 10.1074/jbc.274.31.21499 . PMID : 10419450 . {{ ??????? ?????? ????? }}: ????? ?????????: ??? ????? ??? ???? ( link )

????? ?????? [ ??? ]

Norgett EE? Kelsell DP (2002). "SPINK5: both rare and common skin disease". Trends in Molecular Medicine . ?. 8 ?. 1: 7. DOI : 10.1016/S1471-4914(01)02228-6 . PMID : 11796258 .
Magert HJ? Kreutzmann P? Standker L? ?????? (2002). "LEKTI: a multidomain serine proteinase inhibitor with pathophysiological relevance". Int. J. Biochem. Cell Biol . ?. 34 ?. 6: 573?6. DOI : 10.1016/S1357-2725(01)00179-0 . PMID : 11943586 .
Walden M? Kreutzmann P? Drogemuller K? ?????? (2003). "Biochemical features, molecular biology and clinical relevance of the human 15-domain serine proteinase inhibitor LEKTI". Biol. Chem . ?. 383 ?. 7?8: 1139?41. DOI : 10.1515/BC.2002.124 . PMID : 12437098 .
Chavanas S? Garner C? Bodemer C? ?????? (2000). "Localization of the Netherton syndrome gene to chromosome 5q32, by linkage analysis and homozygosity mapping" . Am. J. Hum. Genet . ?. 66 ?. 3: 914?21. DOI : 10.1086/302824 . PMC : 1288172 . PMID : 10712206 .
Chavanas S? Bodemer C? Rochat A? ?????? (2000). "Mutations in SPINK5, encoding a serine protease inhibitor, cause Netherton syndrome". Nat. Genet . ?. 25 ?. 2: 141?2. DOI : 10.1038/75977 . PMID : 10835624 .
Sprecher E? Chavanas S? DiGiovanna JJ? ?????? (2001). "The spectrum of pathogenic mutations in SPINK5 in 19 families with Netherton syndrome: implications for mutation detection and first case of prenatal diagnosis" . J. Invest. Dermatol . ?. 117 ?. 2: 179?87. DOI : 10.1046/j.1523-1747.2001.01389.x . PMID : 11511292 .
Walley AJ? Chavanas S? Moffatt MF? ?????? (2001). "Gene polymorphism in Netherton and common atopic disease". Nat. Genet . ?. 29 ?. 2: 175?8. DOI : 10.1038/ng728 . PMID : 11544479 .
Ahmed A? Kandola P? Ziada G? Parenteau N (2002). "Purification and partial amino acid sequence of proteins from human epidermal keratinocyte conditioned medium". J. Protein Chem . ?. 20 ?. 4: 273?8. DOI : 10.1023/A:1010902815953 . PMID : 11594460 .
Bitoun E? Chavanas S? Irvine AD? ?????? (2002). "Netherton syndrome: disease expression and spectrum of SPINK5 mutations in 21 families" . J. Invest. Dermatol . ?. 118 ?. 2: 352?61. DOI : 10.1046/j.1523-1747.2002.01603.x . PMID : 11841556 .
Komatsu N? Takata M? Otsuki N? ?????? (2002). "Elevated stratum corneum hydrolytic activity in Netherton syndrome suggests an inhibitory regulation of desquamation by SPINK5-derived peptides" . J. Invest. Dermatol . ?. 118 ?. 3: 436?43. DOI : 10.1046/j.0022-202x.2001.01663.x . PMID : 11874482 .
Bitoun E? Micheloni A? Lamant L? ?????? (2004). "LEKTI proteolytic processing in human primary keratinocytes, tissue distribution and defective expression in Netherton syndrome". Hum. Mol. Genet . ?. 12 ?. 19: 2417?30. DOI : 10.1093/hmg/ddg247 . PMID : 12915442 .
Nishio Y? Noguchi E? Shibasaki M? ?????? (2004). "Association between polymorphisms in the SPINK5 gene and atopic dermatitis in the Japanese". Genes Immun . ?. 4 ?. 7: 515?7. DOI : 10.1038/sj.gene.6363889 . PMID : 14551605 .
Raghunath M? Tontsidou L? Oji V? ?????? (2004). "SPINK5 and Netherton syndrome: novel mutations, demonstration of missing LEKTI, and differential expression of transglutaminases" . J. Invest. Dermatol . ?. 123 ?. 3: 474?83. DOI : 10.1111/j.0022-202X.2004.23220.x . PMID : 15304086 .
Tidow H? Lauber T? Vitzithum K? ?????? (2004). "The solution structure of a chimeric LEKTI domain reveals a chameleon sequence". Biochemistry . ?. 43 ?. 35: 11238?47. DOI : 10.1021/bi0492399 . PMID : 15366933 .
Yang T? Liang D? Koch PJ? ?????? (2004). "Epidermal detachment, desmosomal dissociation, and destabilization of corneodesmosin in Spink5-/- mice" . Genes Dev . ?. 18 ?. 19: 2354?8. DOI : 10.1101/gad.1232104 . PMC : 522985 . PMID : 15466487 .
Ishida-Yamamoto A? Deraison C? Bonnart C? ?????? (2005). "LEKTI is localized in lamellar granules, separated from KLK5 and KLK7, and is secreted in the extracellular spaces of the superficial stratum granulosum". J. Invest. Dermatol . ?. 124 ?. 2: 360?6. DOI : 10.1111/j.0022-202X.2004.23583.x . PMID : 15675955 .

??? ???? ????? ?? ??? ??? ???????? 5 ????? ???????. ????? ???? ?? ???????.

[entrez-1] "Entrez Gene: SPINK5 serine peptidase inhibitor, Kazal type 5" . ????? ?? ????? ?? 2010-12-05.

[pmid10419450-2] Magert HJ? Standker L? Kreutzmann P? Zucht HD? Reinecke M? Sommerhoff CP? Fritz H? Forssmann WG (????? 1999). "LEKTI, a novel 15-domain type of human serine proteinase inhibitor". J Biol Chem . ?. 274 ?. 31: 21499?502. DOI : 10.1074/jbc.274.31.21499 . PMID : 10419450 . {{ ??????? ?????? ????? }}: ????? ?????????: ??? ????? ??? ???? ( link )

[1]

[2]

????????? ??????	???? ??????? ???????? ??? ????? (OMIM) : 605010
???????? ????????	Ensembl Transcript ID : ENST00000508733 ???? ????? ?????? ??????? (UMLS CUI) : C1423506