BCL9

BCL9
??? ??????
??? ?????? ????????	Ortholog search: PDBe RCSB
????? ???? ?????? ??? ?????? ????????
	2GL7 , 2VP7 , 2VPB , 2VPD , 2VPE , 2VPG , 3SL9
??????
????? ?????	BCL9 , LGS, B-cell CLL/lymphoma 9, B cell CLL/lymphoma 9, transcription coactivator, transcription coactivator
?????? ??????	??????? ???????? ??????? ??? ???????? 602597 MGI: MGI:1924828 HomoloGene: 3191 GeneCards: 607
??? ?????? ??????
????? ??????	? beta-catenin binding ; ? ?GO:0001948? ?GO:0016582 ??? ??????? ; ? ?GO:0001105 transcription coactivator activity ;
?????? ?????	? ????????? ; ? cis-Golgi network ; ? ???? ????? ; ? ???? ; ? ????? ???? ; ? beta-catenin-TCF complex ;
?????? ?????	? skeletal muscle cell differentiation ; ? canonical Wnt signaling pathway ; ? ?????? ?????.??.?? ; ? somatic stem cell population maintenance ; ? myotube differentiation involved in skeletal muscle regeneration ; ? ?GO:0003257? ?GO:0010735? ?GO:1901228? ?GO:1900622? ?GO:1904488 ??? ????? ????? ??????? ?? ???? ????????? ????? ?????? ; ? regulation of transforming growth factor beta receptor signaling pathway ; ? beta-catenin-TCF complex assembly ;
	???????: Amigo / QuickGO
??? ??????? ?? ????? ?????? ????????
	?????? ?? ?????? ??????? ????????
??????? ???????
	O00512
	Q9D219
	NM_004326
	?XM_006502288? ?XM_006502289? ?XM_006502290? ?XM_006502292? ?XM_030252891? ?XM_030252892? ?XM_036163404 NM_029933? ?XM_006502288? ?XM_006502289? ?XM_006502290? ?XM_006502292? ?XM_030252891? ?XM_030252892? ?XM_036163404
	?XP_005273028? ?XP_005277474? ?XP_005277475? ?XP_016857515 NP_004317? ?XP_005273028? ?XP_005277474? ?XP_005277475? ?XP_016857515
	?XP_006502351? ?XP_006502352? ?XP_006502353? ?XP_006502355? ?XP_030108751? ?XP_030108752? ?XP_036019297 NP_084209? ?XP_006502351? ?XP_006502352? ?XP_006502353? ?XP_006502355? ?XP_030108751? ?XP_030108752? ?XP_036019297
	???? ??????
????/???? ?????	????/???? ???

BCL9 ? ( B cell CLL/lymphoma 9 ) ??? ?????? ?????? ?????? ??? BCL9 ?? ??????? . ^[1]^[2]

??????? [ ??? ]

??????? ???????? [ ??? ]

??????? [ ??? ]

^ Willis TG? Zalcberg IR? Coignet LJ? Wlodarska I? Stul M? Jadayel DM? Bastard C? Treleaven JG? Catovsky D? Silva ML? Dyer MJ (???? 1998). "Molecular cloning of translocation t(1;14)(q21;q32) defines a novel gene (BCL9) at chromosome 1q21". Blood . ?. 91 ?. 6: 1873?81. PMID : 9490669 .
^ "Entrez Gene: BCL9 B-cell CLL/lymphoma 9" . ????? ?? ????? ?? 2010-12-05.

????? ?????? [ ??? ]

Busson-Le Coniat M? Salomon-Nguyen F? Dastugue N? Maarek O? Lafage-Pochitaloff M? Mozziconacci MJ? Baranger L? Brizard F? Radford I? Jeanpierre M? Bernard OA? Berger R (?????? 1999). "Fluorescence in situ hybridization analysis of chromosome 1 abnormalities in hematopoietic disorders: rearrangements of DNA satellite II and new recurrent translocations". Leukemia . ?. 13 ?. 12: 1975?81. DOI : 10.1038/sj/leu/2401587 . PMID : 10602418 .
Kramps T? Peter O? Brunner E? Nellen D? Froesch B? Chatterjee S? Murone M? Zullig S? Basler K (????? 2002). "Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex". Cell . ?. 109 ?. 1: 47?60. DOI : 10.1016/S0092-8674(02)00679-7 . PMID : 11955446 .
Knoll A? Dvorak J? Rohrer GA? Cepica S (????? 2002). "Linkage and cytogenetic mapping of the BCL9 gene to porcine chromosome 4" . Animal Genetics . ?. 33 ?. 2: 162?3. DOI : 10.1046/j.1365-2052.2002.0831e.x . PMID : 12047235 .
Townsley FM? Thompson B? Bienz M (?????? 2004). "Pygopus residues required for its binding to Legless are critical for transcription and development". The Journal of Biological Chemistry . ?. 279 ?. 7: 5177?83. DOI : 10.1074/jbc.M309722200 . PMID : 14612447 . {{ ??????? ?????? ????? }}: ????? ?????????: ??? ????? ??? ???? ( link )
Hoffmans R? Basler K (?????? 2004). "Identification and in vivo role of the Armadillo-Legless interaction". Development . ?. 131 ?. 17: 4393?400. DOI : 10.1242/dev.01296 . PMID : 15294866 .
Beausoleil SA? Jedrychowski M? Schwartz D? Elias JE? Villen J? Li J? Cohn MA? Cantley LC? Gygi SP (????? 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins" . Proceedings of the National Academy of Sciences of the United States of America . ?. 101 ?. 33: 12130?5. DOI : 10.1073/pnas.0404720101 . PMC : 514446 . PMID : 15302935 .
Sampietro J? Dahlberg CL? Cho US? Hinds TR? Kimelman D? Xu W (?????? 2006). "Crystal structure of a beta-catenin/BCL9/Tcf4 complex". Molecular Cell . ?. 24 ?. 2: 293?300. DOI : 10.1016/j.molcel.2006.09.001 . PMID : 17052462 .
Hoffmans R? Basler K (????? 2007). "BCL9-2 binds Arm/beta-catenin in a Tyr142-independent manner and requires Pygopus for its function in Wg/Wnt signaling". Mechanisms of Development . ?. 124 ?. 1: 59?67. DOI : 10.1016/j.mod.2006.09.006 . PMID : 17113272 .

??? ???? ????? ?? ??? ??? ???????? 1 ????? ???????. ????? ???? ?? ???????.

[pmid9490669-1] Willis TG? Zalcberg IR? Coignet LJ? Wlodarska I? Stul M? Jadayel DM? Bastard C? Treleaven JG? Catovsky D? Silva ML? Dyer MJ (???? 1998). "Molecular cloning of translocation t(1;14)(q21;q32) defines a novel gene (BCL9) at chromosome 1q21". Blood . ?. 91 ?. 6: 1873?81. PMID : 9490669 .

[entrez-2] "Entrez Gene: BCL9 B-cell CLL/lymphoma 9" . ????? ?? ????? ?? 2010-12-05.

[1]

[2]

????????? ??????	???? ??????? ???????? ??? ????? (OMIM) : 602597
???????? ????????	Ensembl Transcript ID : ENST00000684121 ???? ????? ?????? ??????? (UMLS CUI) : C1332402