APBB2

APBB2
??? ??????
??? ?????? ????????	Ortholog search: PDBe RCSB
????? ???? ?????? ??? ?????? ????????
	1WGU , 2ROZ , 2YSZ , 2YT0 , 2YT1
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????? ?????	APBB2 , FE65L, FE65L1, amyloid beta precursor protein binding family B member 2
?????? ??????	??????? ???????? ??????? ??? ???????? 602710 MGI: MGI:108405 HomoloGene: 32079 GeneCards: 323
??? ?????? ??????
????? ??????	? ?GO:0001948? ?GO:0016582 ??? ??????? ; ? transcription factor binding ; ? amyloid-beta binding ;
?????? ?????	? ????? ????? ; ? ???? ; ? ????????? ; ? lamellipodium ; ? ???? ???? ; ? ???? ;
?????? ?????	? positive regulation of apoptotic process ; ? ?GO:0007243 intracellular signal transduction ; ? negative regulation of cell growth ; ? negative regulation of apoptotic process ; ? extracellular matrix organization ; ? axon guidance ; ? neuron migration ; ? ?GO:0009373 ??? ??? ????? ;
	???????: Amigo / QuickGO
??? ??????? ?? ????? ?????? ????????
	; ; ; ;
	?????? ?? ?????? ??????? ????????
??????? ???????
	Q92870 ; D6RAJ4
	Q9DBR4
	?NM_001166050? ?NM_001166051? ?NM_001166052? ?NM_001166053? ?NM_001166054? ?NM_004307? ?NM_173075? ?XM_006714005? ?XM_006714007? ?XM_006714008? ?XM_006714009? ?XM_006714010? ?XM_006714011? ?XM_006714012? ?XM_011513686? ?XM_011513687? ?XM_017008143? ?XM_017008144? ?XM_017008145? ?XM_017008146? ?XM_017008147? ?XM_017008148? ?XM_017008149? ?XM_017008151? ?XM_017008152? ?XM_017008154? ?XM_017008156? ?XM_017008157? ?XM_017008158? ?NM_001330656? ?NM_001330658 XM_011513688? ?NM_001166050? ?NM_001166051? ?NM_001166052? ?NM_001166053? ?NM_001166054? ?NM_004307? ?NM_173075? ?XM_006714005? ?XM_006714007? ?XM_006714008? ?XM_006714009? ?XM_006714010? ?XM_006714011? ?XM_006714012? ?XM_011513686? ?XM_011513687? ?XM_017008143? ?XM_017008144? ?XM_017008145? ?XM_017008146? ?XM_017008147? ?XM_017008148? ?XM_017008149? ?XM_017008151? ?XM_017008152? ?XM_017008154? ?XM_017008156? ?XM_017008157? ?XM_017008158? ?NM_001330656? ?NM_001330658
	?NM_001201414? ?NM_001201415? ?NM_001201416? ?NM_009686? ?XM_006503688? ?XM_006503690? ?XM_006503691? ?XM_006503692? ?XM_006503693? ?XM_006503694? ?XM_006503696? ?XM_006503697? ?NM_001310626? ?XM_011240693? ?XM_017320620? ?XM_017320622? ?XM_030254078? ?XM_030254079? ?XM_030254080? ?XM_030254081? ?XM_030254082? ?XM_036164746? ?XM_036164747? ?XM_036164748? ?XM_036164749 NM_001201413? ?NM_001201414? ?NM_001201415? ?NM_001201416? ?NM_009686? ?XM_006503688? ?XM_006503690? ?XM_006503691? ?XM_006503692? ?XM_006503693? ?XM_006503694? ?XM_006503696? ?XM_006503697? ?NM_001310626? ?XM_011240693? ?XM_017320620? ?XM_017320622? ?XM_030254078? ?XM_030254079? ?XM_030254080? ?XM_030254081? ?XM_030254082? ?XM_036164746? ?XM_036164747? ?XM_036164748? ?XM_036164749
	?NP_001159523? ?NP_001159524? ?NP_001159525? ?NP_001159526? ?NP_001317585? ?NP_001317587? ?NP_004298? ?NP_775098? ?XP_006714068? ?XP_006714070? ?XP_006714071? ?XP_006714072? ?XP_006714073? ?XP_006714074? ?XP_006714075? ?XP_011511988? ?XP_011511989? ?XP_011511990? ?XP_016863632? ?XP_016863633? ?XP_016863634? ?XP_016863635? ?XP_016863636? ?XP_016863637? ?XP_016863638? ?XP_016863640? ?XP_016863641? ?XP_016863643? ?XP_016863645? ?XP_016863646? ?XP_016863647 NP_001159522? ?NP_001159523? ?NP_001159524? ?NP_001159525? ?NP_001159526? ?NP_001317585? ?NP_001317587? ?NP_004298? ?NP_775098? ?XP_006714068? ?XP_006714070? ?XP_006714071? ?XP_006714072? ?XP_006714073? ?XP_006714074? ?XP_006714075? ?XP_011511988? ?XP_011511989? ?XP_011511990? ?XP_016863632? ?XP_016863633? ?XP_016863634? ?XP_016863635? ?XP_016863636? ?XP_016863637? ?XP_016863638? ?XP_016863640? ?XP_016863641? ?XP_016863643? ?XP_016863645? ?XP_016863646? ?XP_016863647
	?NP_001188343? ?NP_001188344? ?NP_001188345? ?NP_001297555? ?NP_033816? ?XP_006503751? ?XP_006503753? ?XP_006503754? ?XP_006503755? ?XP_006503756? ?XP_006503757? ?XP_006503759? ?XP_006503760? ?XP_011238995? ?XP_017176109? ?XP_017176111? ?XP_030109938? ?XP_030109939? ?XP_030109940? ?XP_030109941? ?XP_030109942? ?XP_036020639? ?XP_036020640? ?XP_036020641? ?XP_036020642 NP_001188342? ?NP_001188343? ?NP_001188344? ?NP_001188345? ?NP_001297555? ?NP_033816? ?XP_006503751? ?XP_006503753? ?XP_006503754? ?XP_006503755? ?XP_006503756? ?XP_006503757? ?XP_006503759? ?XP_006503760? ?XP_011238995? ?XP_017176109? ?XP_017176111? ?XP_030109938? ?XP_030109939? ?XP_030109940? ?XP_030109941? ?XP_030109942? ?XP_036020639? ?XP_036020640? ?XP_036020641? ?XP_036020642
	???? ??????
????/???? ?????	????/???? ???

APBB2 ? ( Amyloid beta precursor protein binding family B member 2 ) ??? ?????? ?????? ?????? ??? APBB2 ?? ??????? . ^[1]^[2]^[3]^[3]

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^ Blanco G? Irving NG? Brown SD? Miller CC? McLoughlin DM (????? 1998). "Mapping of the human and murine X11-like genes (APBA2 and apba2), the murine Fe65 gene (Apbb1), and the human Fe65-like gene (APBB2): genes encoding phosphotyrosine-binding domain proteins that interact with the Alzheimer's disease amyloid precursor protein". Mamm Genome . ?. 9 ?. 6: 473?5. DOI : 10.1007/s003359900800 . PMID : 9585438 .
^ McLoughlin DM? Miller CC (????? 1997). "The intracellular cytoplasmic domain of the Alzheimer's disease amyloid precursor protein interacts with phosphotyrosine-binding domain proteins in the yeast two-hybrid system". FEBS Lett . ?. 397 ?. 2?3: 197?200. DOI : 10.1016/S0014-5793(96)01128-3 . PMID : 8955346 .
^ ^? ^? "Entrez Gene: APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 (Fe65-like)" . ????? ?? ????? ?? 2010-03-06.

????? ?????? [ ??? ]

Guenette SY? Chen J? Jondro PD? Tanzi RE (1996). "Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein" . Proc. Natl. Acad. Sci. U.S.A . ?. 93 ?. 20: 10832?7. DOI : 10.1073/pnas.93.20.10832 . PMC : 38241 . PMID : 8855266 .
Bruni P? Minopoli G? Brancaccio T? ?????? (2002). "Fe65, a ligand of the Alzheimer's beta-amyloid precursor protein, blocks cell cycle progression by down-regulating thymidylate synthase expression". J. Biol. Chem . ?. 277 ?. 38: 35481?8. DOI : 10.1074/jbc.M205227200 . PMID : 12089154 . {{ ??????? ?????? ????? }}: ????? ?????????: ??? ????? ??? ???? ( link )
Strausberg RL? Feingold EA? Grouse LH? ?????? (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . ?. 99 ?. 26: 16899?903. DOI : 10.1073/pnas.242603899 . PMC : 139241 . PMID : 12477932 .
Chang Y? Tesco G? Jeong WJ? ?????? (2004). "Generation of the beta-amyloid peptide and the amyloid precursor protein C-terminal fragment gamma are potentiated by FE65L1". J. Biol. Chem . ?. 278 ?. 51: 51100?7. DOI : 10.1074/jbc.M309561200 . PMID : 14527950 . {{ ??????? ?????? ????? }}: ????? ?????????: ??? ????? ??? ???? ( link )
Gerhard DS? Wagner L? Feingold EA? ?????? (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . ?. 14 ?. 10B: 2121?7. DOI : 10.1101/gr.2596504 . PMC : 528928 . PMID : 15489334 .
Li Y? Hollingworth P? Moore P? ?????? (2006). "Genetic association of the APP binding protein 2 gene (APBB2) with late onset Alzheimer disease". Hum. Mutat . ?. 25 ?. 3: 270?7. DOI : 10.1002/humu.20138 . PMID : 15714520 .
Lange A? Thon L? Mathieu S? Adam D (2005). "The apoptosis inhibitory domain of FE65-like protein 1 regulates both apoptotic and caspase-independent programmed cell death mediated by tumor necrosis factor". Biochem. Biophys. Res. Commun . ?. 335 ?. 2: 575?83. DOI : 10.1016/j.bbrc.2005.07.125 . PMID : 16083851 .
Rual JF? Venkatesan K? Hao T? ?????? (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . ?. 437 ?. 7062: 1173?8. DOI : 10.1038/nature04209 . PMID : 16189514 .
Hong Q? Hsu LJ? Schultz L? ?????? (2007). "Zfra affects TNF-mediated cell death by interacting with death domain protein TRADD and negatively regulates the activation of NF-κB, JNK1, p53 and WOX1 during stress response" . BMC Mol. Biol . ?. 8: 50. DOI : 10.1186/1471-2199-8-50 . PMC : 1904229 . PMID : 17567906 . {{ ??????? ?????? ????? }}: ????? ?????????: ??? ????? ??? ???? ( link )

??? ???? ????? ?? ??? ??? ???????? 4 ????? ???????. ????? ???? ?? ???????.

[pmid9585438-1] Blanco G? Irving NG? Brown SD? Miller CC? McLoughlin DM (????? 1998). "Mapping of the human and murine X11-like genes (APBA2 and apba2), the murine Fe65 gene (Apbb1), and the human Fe65-like gene (APBB2): genes encoding phosphotyrosine-binding domain proteins that interact with the Alzheimer's disease amyloid precursor protein". Mamm Genome . ?. 9 ?. 6: 473?5. DOI : 10.1007/s003359900800 . PMID : 9585438 .

[pmid8955346-2] McLoughlin DM? Miller CC (????? 1997). "The intracellular cytoplasmic domain of the Alzheimer's disease amyloid precursor protein interacts with phosphotyrosine-binding domain proteins in the yeast two-hybrid system". FEBS Lett . ?. 397 ?. 2?3: 197?200. DOI : 10.1016/S0014-5793(96)01128-3 . PMID : 8955346 .

[entrez-3] ? ^? "Entrez Gene: APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 (Fe65-like)" . ????? ?? ????? ?? 2010-03-06.

[1]

[2]

[3]

????????? ??????	???? ??????? ???????? ??? ????? (OMIM) : 602710
???????? ????????	Ensembl Transcript ID : ENST00000514920 ???? ????? ?????? ??????? (UMLS CUI) : C1412460