AKAP5

AKAP5
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??? ?????? ????????	Ortholog search: PDBe RCSB
????? ???? ?????? ??? ?????? ????????
	2H9R , 3LL8
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????? ?????	AKAP5 , AKAP75, AKAP79, H21, A-kinase anchoring protein 5
?????? ??????	??????? ???????? ??????? ??? ???????? 604688 MGI: MGI:2685104 HomoloGene: 15854 GeneCards: 9495
??? ?????? ??????
????? ??????	? protein kinase A binding ; ? calmodulin binding ; ? ?GO:0001948? ?GO:0016582 ??? ??????? ; ? protein kinase A regulatory subunit binding ; ? adenylate cyclase binding ; ? SH3 domain binding ; ? protein phosphatase 2B binding ; ? beta-2 adrenergic receptor binding ; ? ?GO:0032947 molecular adaptor activity ; ? glutamate receptor binding ; ? GABA receptor binding ; ? scaffold protein binding ;
?????? ?????	? ????? ????? ; ? ???? ; ? ???? ???? ; ? cytoplasmic side of plasma membrane ; ? ?GO:0097483? ?GO:0097481 ????? ??? ??????? ; ? dendrite membrane ; ? ???? ?????? ; ? ?????? ????? ; ? excitatory synapse ; ? ???? ???? ;
?????? ?????	? ????? ???????? ; ? ?GO:0072468 ????? ??????? ; ? positive regulation of protein kinase A signaling ; ? chemical synaptic transmission ; ? adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ; ? negative regulation of adenylate cyclase activity ; ? regulation of protein kinase A signaling ; ? positive regulation of adenylate cyclase activity ; ? positive regulation of protein localization to plasma membrane ;
	???????: Amigo / QuickGO
??? ??????? ?? ????? ?????? ????????
	?????? ?? ?????? ??????? ????????
??????? ???????
	P24588 ; Q6PG46
	D3YVF0
	NM_004857
	?XM_006515842 NM_001101471? ?XM_006515842
	NP_004848 ; NP_004848.3
	?XP_006515905 NP_001094941? ?XP_006515905
	???? ??????
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AKAP5 ? ( A-kinase anchoring protein 5 ) ??? ?????? ?????? ?????? ??? AKAP5 ?? ??????? . ^[1]^[2]^[3]

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^ "Entrez Gene: AKAP5 A kinase (PRKA) anchor protein 5" . ????? ?? ????? ?? 2010-12-05.
^ Carr DW? Hausken ZE? Fraser ID? Stofko-Hahn RE? Scott JD (????? 1992). "Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain". J Biol Chem . ?. 267 ?. 19: 13376?82. PMID : 1618839 .
^ Carr DW? Stofko-Hahn RE? Fraser ID? Cone RD? Scott JD (?????? 1992). "Localization of the cAMP-dependent protein kinase to the postsynaptic densities by A-kinase anchoring proteins. Characterization of AKAP 79". J Biol Chem . ?. 267 ?. 24: 16816?23. PMID : 1512224 .

????? ?????? [ ??? ]

Lester LB? Scott JD (1997). "Anchoring and scaffold proteins for kinases and phosphatases". Recent Prog. Horm. Res . ?. 52: 409?29, discussion 429?30. PMID : 9238861 .
Michel JJ? Scott JD (2002). "AKAP mediated signal transduction" . Annu. Rev. Pharmacol. Toxicol . ?. 42: 235?57. DOI : 10.1146/annurev.pharmtox.42.083101.135801 . PMID : 11807172 .
Hirsch AH? Glantz SB? Li Y? ?????? (1992). "Cloning and expression of an intron-less gene for AKAP 75, an anchor protein for the regulatory subunit of cAMP-dependent protein kinase II beta". J. Biol. Chem . ?. 267 ?. 4: 2131?4. PMID : 1733921 .
Carr DW? Stofko-Hahn RE? Fraser ID? ?????? (1991). "Interaction of the regulatory subunit (RII) of cAMP-dependent protein kinase with RII-anchoring proteins occurs through an amphipathic helix binding motif". J. Biol. Chem . ?. 266 ?. 22: 14188?92. PMID : 1860836 .
Coghlan VM? Perrino BA? Howard M? ?????? (1995). "Association of protein kinase A and protein phosphatase 2B with a common anchoring protein". Science . ?. 267 ?. 5194: 108?11. DOI : 10.1126/science.7528941 . PMID : 7528941 .
Glantz SB? Li Y? Rubin CS (1993). "Characterization of distinct tethering and intracellular targeting domains in AKAP75, a protein that links cAMP-dependent protein kinase II beta to the cytoskeleton". J. Biol. Chem . ?. 268 ?. 17: 12796?804. PMID : 8509414 .
Faux MC? Scott JD (1997). "Regulation of the AKAP79-protein kinase C interaction by Ca2+/Calmodulin". J. Biol. Chem . ?. 272 ?. 27: 17038?44. DOI : 10.1074/jbc.272.27.17038 . PMID : 9202019 . {{ ??????? ?????? ????? }}: ????? ?????????: ??? ????? ??? ???? ( link )
Kashishian A? Howard M? Loh C? ?????? (1998). "AKAP79 inhibits calcineurin through a site distinct from the immunophilin-binding region". J. Biol. Chem . ?. 273 ?. 42: 27412?9. DOI : 10.1074/jbc.273.42.27412 . PMID : 9765270 . {{ ??????? ?????? ????? }}: ????? ?????????: ??? ????? ??? ???? ( link )
Paolillo M? Feliciello A? Porcellini A? ?????? (1999). "The type and the localization of cAMP-dependent protein kinase regulate transmission of cAMP signals to the nucleus in cortical and cerebellar granule cells". J. Biol. Chem . ?. 274 ?. 10: 6546?52. DOI : 10.1074/jbc.274.10.6546 . PMID : 10037748 . {{ ??????? ?????? ????? }}: ????? ?????????: ??? ????? ??? ???? ( link )
Dodge KL? Carr DW? Sanborn BM (1999). "Protein kinase A anchoring to the myometrial plasma membrane is required for cyclic adenosine 3',5'-monophosphate regulation of phosphatidylinositide turnover". Endocrinology . ?. 140 ?. 11: 5165?70. DOI : 10.1210/en.140.11.5165 . PMID : 10537145 .
Fraser ID? Cong M? Kim J? ?????? (2000). "Assembly of an A kinase-anchoring protein-beta(2)-adrenergic receptor complex facilitates receptor phosphorylation and signaling". Curr. Biol . ?. 10 ?. 7: 409?12. DOI : 10.1016/S0960-9822(00)00419-X . PMID : 10753752 .
Sik A? Gulacsi A? Lai Y? ?????? (2000). "Localization of the A kinase anchoring protein AKAP79 in the human hippocampus". Eur. J. Neurosci . ?. 12 ?. 4: 1155?64. DOI : 10.1046/j.1460-9568.2000.00002.x . PMID : 10762347 .
Colledge M? Dean RA? Scott GK? ?????? (2000). "Targeting of PKA to glutamate receptors through a MAGUK-AKAP complex". Neuron . ?. 27 ?. 1: 107?19. DOI : 10.1016/S0896-6273(00)00013-1 . PMID : 10939335 .
Indolfi C? Stabile E? Coppola C? ?????? (2001). "Membrane-bound protein kinase A inhibits smooth muscle cell proliferation in vitro and in vivo by amplifying cAMP-protein kinase A signals". Circ. Res . ?. 88 ?. 3: 319?24. DOI : 10.1161/01.res.88.3.319 . PMID : 11179200 .
Dart C? Leyland ML (2001). "Targeting of an A kinase-anchoring protein, AKAP79, to an inwardly rectifying potassium channel, Kir2.1". J. Biol. Chem . ?. 276 ?. 23: 20499?505. DOI : 10.1074/jbc.M101425200 . PMID : 11287423 . {{ ??????? ?????? ????? }}: ????? ?????????: ??? ????? ??? ???? ( link )
Xie G? Raufman JP (2001). "Association of protein kinase A with AKAP150 facilitates pepsinogen secretion from gastric chief cells". Am. J. Physiol. Gastrointest. Liver Physiol . ?. 281 ?. 4: G1051?8. PMID : 11557526 .

??? ??? ?? ????:Wikidata2 ??? ????? 69: assign to undeclared variable 'isvalid'.

??? ???? ????? ?? ??? ??? ???????? 14 ????? ???????. ????? ???? ?? ???????.

[entrez-1] "Entrez Gene: AKAP5 A kinase (PRKA) anchor protein 5" . ????? ?? ????? ?? 2010-12-05.

[pmid1618839-2] Carr DW? Hausken ZE? Fraser ID? Stofko-Hahn RE? Scott JD (????? 1992). "Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain". J Biol Chem . ?. 267 ?. 19: 13376?82. PMID : 1618839 .

[pmid1512224-3] Carr DW? Stofko-Hahn RE? Fraser ID? Cone RD? Scott JD (?????? 1992). "Localization of the cAMP-dependent protein kinase to the postsynaptic densities by A-kinase anchoring proteins. Characterization of AKAP 79". J Biol Chem . ?. 267 ?. 24: 16816?23. PMID : 1512224 .

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