AFAP1

AFAP1
??????
????? ?????	AFAP1 , AFAP, AFAP-110, 10, actin filament associated protein 1
?????? ??????	??????? ???????? ??????? ??? ???????? 608252 MGI: MGI:1917542 HomoloGene: 11009 GeneCards: 60312
??? ?????? ??????
????? ??????	? actin binding ; ? SH3 domain binding ; ? SH2 domain binding ;
?????? ?????	? ????????? ; ? ???? ???? ; ? ???????? ????? ; ? ????? ????? ; ? actin cytoskeleton ;
?????? ?????	? regulation of signal transduction ; ? regulation of cytoskeleton organization ;
	???????: Amigo / QuickGO
??? ??????? ?? ????? ?????? ????????
	?????? ?? ?????? ??????? ????????
??????? ???????
	Q8N556
	Q80YS6
	?NM_021638? ?NM_198595? ?XM_006713909? ?XM_011513544? ?XM_017008535? ?XM_017008536? ?NM_001371090? ?NM_001371091? ?XM_047416061 NM_001134647? ?NM_021638? ?NM_198595? ?XM_006713909? ?XM_011513544? ?XM_017008535? ?XM_017008536? ?NM_001371090? ?NM_001371091? ?XM_047416061
	?XM_006504098? ?XM_030254799? ?XM_030254800 NM_027373? ?XM_006504098? ?XM_030254799? ?XM_030254800
	?NP_940997? ?XP_006713972? ?XP_011511846? ?XP_016864024? ?XP_016864025? ?NP_001358019? ?NP_001358020 NP_001128119? ?NP_940997? ?XP_006713972? ?XP_011511846? ?XP_016864024? ?XP_016864025? ?NP_001358019? ?NP_001358020
	?XP_006504161? ?XP_030110659? ?XP_030110660? ?NP_001390348? ?NP_001390349? ?NP_001390350 NP_081649? ?XP_006504161? ?XP_030110659? ?XP_030110660? ?NP_001390348? ?NP_001390349? ?NP_001390350
	???? ??????
????/???? ?????	????/???? ???

AFAP1 ? ( Actin filament associated protein 1 ) ??? ?????? ?????? ?????? ??? AFAP1 ?? ??????? . ^[1]^[2]^[3]^[4]

??????? [ ??? ]

??????? ???????? [ ??? ]

??????? [ ??? ]

^ "Entrez Gene: AFAP1 actin filament associated protein 1" . ????? ?? ????? ?? 2010-12-05.
^ Qian Y? Gatesman AS? Baisden JM? Zot HG? Cherezova L? Qazi I? Mazloum N? Lee MY? Guappone-Koay A? Flynn DC (?????? 2004). "Analysis of the role of the leucine zipper motif in regulating the ability of AFAP-110 to alter actin filament integrity". J Cell Biochem . ?. 91 ?. 3: 602?20. DOI : 10.1002/jcb.10725 . PMID : 14755689 .
^ Baisden JM? Gatesman AS? Cherezova L? Jiang BH? Flynn DC (?????? 2001). "The intrinsic ability of AFAP-110 to alter actin filament integrity is linked with its ability to also activate cellular tyrosine kinases". Oncogene . ?. 20 ?. 45: 6607?16. DOI : 10.1038/sj.onc.1204802 . PMID : 11641786 .
^ Baisden JM? Qian Y? Zot HM? Flynn DC (?????? 2001). "The actin filament-associated protein AFAP-110 is an adaptor protein that modulates changes in actin filament integrity". Oncogene . ?. 20 ?. 44: 6435?47. DOI : 10.1038/sj.onc.1204784 . PMID : 11607843 .

????? ?????? [ ??? ]

Ishida Y? Hadano S? Nagayama T? ?????? (1995). "Isolation and characterization of 21 novel expressed DNA sequences from the distal region of human chromosome 4p". Genomics . ?. 22 ?. 2: 302?12. DOI : 10.1006/geno.1994.1388 . PMID : 7545969 .
Qian Y? Baisden JM? Westin EH? ?????? (1998). "Src can regulate carboxy terminal interactions with AFAP-110, which influence self-association, cell localization and actin filament integrity". Oncogene . ?. 16 ?. 17: 2185?95. DOI : 10.1038/sj.onc.1201753 . PMID : 9619827 .
Guappone AC? Weimer T? Flynn DC (1998). "Formation of a stable src-AFAP-110 complex through either an amino-terminal or a carboxy-terminal SH2-binding motif". Mol. Carcinog . ?. 22 ?. 2: 110?9. DOI : 10.1002/(SICI)1098-2744(199806)22:2<110::AID-MC6>3.0.CO;2-Q . PMID : 9655255 .
Qian Y? Baisden JM? Zot HG? ?????? (2000). "The carboxy terminus of AFAP-110 modulates direct interactions with actin filaments and regulates its ability to alter actin filament integrity and induce lamellipodia formation". Exp. Cell Res . ?. 255 ?. 1: 102?13. DOI : 10.1006/excr.1999.4795 . PMID : 10666339 .
Qian Y? Baisden JM? Cherezova L? ?????? (2003). "PC phosphorylation increases the ability of AFAP-110 to cross-link actin filaments" . Mol. Biol. Cell . ?. 13 ?. 7: 2311?22. DOI : 10.1091/mbc.E01-12-0148 . PMC : 117315 . PMID : 12134071 .
Strausberg RL? Feingold EA? Grouse LH? ?????? (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . ?. 99 ?. 26: 16899?903. DOI : 10.1073/pnas.242603899 . PMC : 139241 . PMID : 12477932 .
Brandenberger R? Wei H? Zhang S? ?????? (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol . ?. 22 ?. 6: 707?16. DOI : 10.1038/nbt971 . PMID : 15146197 .
Ballif BA? Villen J? Beausoleil SA? ?????? (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics . ?. 3 ?. 11: 1093?101. DOI : 10.1074/mcp.M400085-MCP200 . PMID : 15345747 . {{ ??????? ?????? ????? }}: ????? ?????????: ??? ????? ??? ???? ( link )
Rual JF? Venkatesan K? Hao T? ?????? (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . ?. 437 ?. 7062: 1173?8. DOI : 10.1038/nature04209 . PMID : 16189514 .
Kimura K? Wakamatsu A? Suzuki Y? ?????? (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes" . Genome Res . ?. 16 ?. 1: 55?65. DOI : 10.1101/gr.4039406 . PMC : 1356129 . PMID : 16344560 .
Dorfleutner A? Stehlik C? Zhang J? ?????? (2007). "AFAP-110 is required for actin stress fiber formation and cell adhesion in MDA-MB-231 breast cancer cells". J. Cell. Physiol . ?. 213 ?. 3: 740?9. DOI : 10.1002/jcp.21143 . PMID : 17520695 .

??? ???? ????? ?? ??? ??? ???????? 4 ????? ???????. ????? ???? ?? ???????.

[1] "Entrez Gene: AFAP1 actin filament associated protein 1" . ????? ?? ????? ?? 2010-12-05.

[2] Qian Y? Gatesman AS? Baisden JM? Zot HG? Cherezova L? Qazi I? Mazloum N? Lee MY? Guappone-Koay A? Flynn DC (?????? 2004). "Analysis of the role of the leucine zipper motif in regulating the ability of AFAP-110 to alter actin filament integrity". J Cell Biochem . ?. 91 ?. 3: 602?20. DOI : 10.1002/jcb.10725 . PMID : 14755689 .

[3] Baisden JM? Gatesman AS? Cherezova L? Jiang BH? Flynn DC (?????? 2001). "The intrinsic ability of AFAP-110 to alter actin filament integrity is linked with its ability to also activate cellular tyrosine kinases". Oncogene . ?. 20 ?. 45: 6607?16. DOI : 10.1038/sj.onc.1204802 . PMID : 11641786 .

[4] Baisden JM? Qian Y? Zot HM? Flynn DC (?????? 2001). "The actin filament-associated protein AFAP-110 is an adaptor protein that modulates changes in actin filament integrity". Oncogene . ?. 20 ?. 44: 6435?47. DOI : 10.1038/sj.onc.1204784 . PMID : 11607843 .

[1]

[2]

[3]

[4]

????????? ??????	???? ??????? ???????? ??? ????? (OMIM) : 608252
???????? ????????	Ensembl Transcript ID : ENST00000612691 ???? ????? ?????? ??????? (UMLS CUI) : C1842350