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???? ?????????? ?????? ???? ? ?? ??? ?? ?????? ?????????? ???? ???? ?? ???? ???? ???? ??????? ??? ??????? ?? ??????????. ^[1] ???? ???? ??????? ??? ??????? ???????? ???? ?? ????? ??? 2016 ?? ??????? ???????? ???? ?????????? ?????? ????? ?? ??? ?? ??????? ?????? ??? ???? 2013 ? 2016? ^[2]^[3] ???? ???? ??? ??????? ?? ???? ?? ?????? ??? 2018 ???? ?????? ?????????? ?? ??????? 2018- 2019. ^[4]

???? ?????? ?? ??? ?????? ???? ?????? ??? ??? ???? ?????? ?????????? ???? ???? ????? ?? ?????? ??????. ????? ???? ?????????? ?????? ???? ?? ???? ????? ? ????? ????? ???????? ???????? ?? ???? ????? ??????. ????? ???? ?????????? ?????? ???? ??? ????? ??????? ??? ???? FluMist ?? ???????? ??????? ????? ??????? ????? Fluenz Tetra ?? ?????? . ???? ???? ???????? ???? ??? ???? ?????? ????? ???? ??? ?? ??? 2003. ^[5]^[6]^[7]

??????????? ?????? [ ??? ]

???? ???? ??????? ??? ??????? ???????? ???? ?? ??? 2016 ???? ??????? ???? ?????????? ?????? ???? ?? ???? ?????????? ???? 2016-2017? ????? -????? ?? ???- ???????? ??? ??? ?? ?????? ??????????. ???? ??? ??????? ???? ??? ?????? ??? ????? ?? ???????? ??? ???? 2013 ?2016? ?? ??? ?????? ??? ???? ???? ???? 2015- 2016. ????? ?????? 2012 ??? ?? ???? ?????????? ?????? ???? ???? ??????? ??????????? ??? ??? ???? ?? ?? ??? ????? ??? ?? ???????. ??? ????? ??? ????? ??? ???????? ??????? ?? ??????? ?? ?????????? ???? ???? ??????? ?????? ????? ???? ???? 50%. ??? ?????? ??? ???? ?? ???????? ???? ??? ?? ?????? ???? ??? ?????? ???????? ??? ?????. ^[8]^[9]

??? ???? ????? ?????? ?????????? ???????? ?????? ??????? ???????? ???? ?? ?????? ??? 2018 ??????? ???????? ???? ?????????? ?????? ???? ??????? ?? ???? ?????????? 2018- 2019. ?? ??? ?????? ?????????? ???????? ????? ??? ?????? ?????????? ???????? ?????? ??????? ???????? ???? ??? ???. ^[4]

????? ????????? [ ??? ]

???? ??????? ???? ?????????? ?????? ???? ?? ????????? ???????? ???????:

??????? ??? ?? 24 ????? ???? ?????? ????? ???????? ?? ??????. ^[10]
??????? ????? ????? ?? ?????? ?? ??? ???????? ????? ????? ???? ?? ??????????. ^[10]
??????? ????? ?????? ?? ??? ???????? ?????? ?? ????? ?? ???????? ????? ?? ??????????? ?? ????????? ?? ????????? ?? ??? ?? ???? ??? ?? ?????? ??????. ^[10]
??????? ????? ?????? ?? ???? ???? ?????? ???????? ???????? ?????? ??? ?? ??? ???????? ?????? ????? ?? ????? ??????? ??? ????? ?? ??? ???? ?????? ?????????. ^[11]
??????? ????? ?????? ?? ?????? ?? ????? ?????? ?? ???????? ?????? ???? ???? ??????? ?? ????? ???????? ????? ???? ???? ???????. ^[11]
??????? ????? ??? ??????? ?? 5 ????? ??????? ?? ?????? ???????. ^[11]
???????? ???????? ????????? ?????????. ^[11]
??????? ????? ????? ?????? ?? ??????? ????? ????? ??? ?????? ???? ???? ?????? ??????. ^[11]
?????? ???????. ^[11]
??????? ????? ?????? ?? ???????? ???? ??? ?????? ?? ?? ???? ?? ?????? ???? ?????. ^[11]

??????? [ ??? ]

????? ?????? ?????? ??????? ??? ????? ?? ?????????? ?? ???? ????? ? ??????? ???? ??? ?? ????? ????? ????? ?????? (????? ??????? ????? ????? ????? ???? ???? 25 ???? ?????)? ????? ?????? ???? ??? ?? ???? ????? ????? (??? ???? ?? ??????? ???? ????? ??? ?????). ????? ??????? ???? ???? ?????????? ??????? (????????? ?????????) ?? ??? ?????? ???????? ????? ????? ??????? ??????? ?? ?????? ?????? ???? ?????? ??? ???? ???? ?? ?????? ???????. ???? ??? ????? ?????? ????????? ??????? ?? ??? ?????? ???????? ??????? ????? ??????. ???? ??????? ??????? ??? ????? ??????? ???????? ????? ????? ??????? ?????? ??????? ???? ?????? ??????? ?? ??????? ?? ????? ???????? ???? ????? ??? ??????? ????????? ??????????? ?????????? ?????????? ??????? ?? ???????? ????? ??? ?????? ?????? ???????? ???????. ^[12]

??????? [ ??? ]

??? ????? ?? ?? ??????? ?? ???? ?????????? ?????? ???? ???? (????? ?? ??????)? ???? ?? ???? ????? ??? ?? ?? ????? ?? ??????? ?????? ?? ???? ??????? ?????? ???? ?? ??????? ????? ?????? ?? ??? ?? ????? ??????? ?? ?? ????? ???? ???? ?????. ???? ???????? ???? ?????????? ?????? ???? ???????? ?? ??? 2010 ??????? ????? ?????? ??????? ??? 2 ?49 ??? ???? ??? ???? ?? ??????? ????? ?????? ?? ??? ?????? ??????? ?? ?????? ??????? ?? ??????? ????? ?????? ?? ????? ????? ?????. ?? ???????? ?? ????? ?????? ????????? ???????? ??? ????? ??? ??? ???? ?? ???? ????? ?????. ?? ???? ??????? ????? ?????? ???? ?????????? ?????? ???? ????? ????? ?? ????? ?????? ???? ??????? ?????? ???? ?? ????? ??????? ???????? ????????? ?????? ???? ???? ?????? ?????? ????? ??? ??? ???? ??????? ???????? ????? ?????? (??? ???? ??????: ?? ???? ????? ??? ??? ???). ?? ???? ?????? ?????? ??????? ?? ?????? ???????? ???? (?????? ???? ?? ???).

?????? ???????? [ ??? ]

????? ???? ???? ???? ???? ??????? ??????? ????? ?????????? ?????? ???? ???? ????? ??? ????? ??????? ≪???????- FluMist≫ ?? ???????? ??????? ?≪?????? ?????- Fluenz Tetra≫ ?? ?????? . ??? ??? ???? ?? ???? ?????????? 2010- 2011 ?? ???? ?????????? ?????? ???? ?????? ??????? ?? ??? ????? ?????? ??????? ????????? ?? ???????? ??????? ?????????. ???? ???? ???????? ?????? ???? ????? ????? ????? ??????? ??????? ????? ?? ?????? ???????? ??????. ???? ???????? ??? ???? ?????????? ?????? ???? ???? ????? ?? ???? ?????? ?????? ?????? ???????? ???????? H1N1 ?????? ?? ?????? ??? 2009? ????? ????? ????? ??????? ????????? ??? ??????? ???? ????? ??????? ?? ??????? ???????? ?? ??? 2011? ???? ?? ???? ??????? ??? ??? 2012 . ^[13]^[14]^[15]

???????? ?? ??? 2007? ???? ?????? ??????? ?????? ???? ????? ???? ???? ?????????? ?????? ???? ?? ???? ??????? ??????????. ???? ??????? ???? ????? ?????? ?? ????? ????? ????????? ?? ?? ??? ?? ??????????? ??????? ?????? ???? ?? ????? ?????? ?? ????? ?????? ?? ????? ????? ????????. ???? ?? ?? ??? ?? ?????? ???? ?????????? ?????? ???? ????? ??????? ????????? ???????? H1N1 ????? ????? ??? 2016. ???? ???? ?? ?? ??? ?? ??? ???????? ??????? ?????? ??? ??????? ?????? ?? ????? ????? ???????? ?? ???????? ??????? ??? ?? ???? ???? ??????? ????? ??????? ?? ????? ??????? ??????? ??? ???????. ???? ??????? ???? ???????? ????? ????? ?? ????? ???? ???? ?????? ????? ??????? ?? ??????? ?????????? ??????? ????? ??????? ????????? ???????? ???????? ?????????? ????????? ??????? ????????? ??????? ?? ???????? . ??? ??? ?????? ??? ??? 2007 ????? ?????? ?????? ???? ?????????? ??????? ???? ??????. ???? ???????? ??? ???? ??????? ?????? ???? ?????? ????????? ???????? ?? ?????? ??? 2009. ????? ????? ??????? ????????? ?? ??? 2011 ??? ?????? ??????? ?? ??????? ???????? ??? ??? ≪??????- Fluenz≫.

??????? [ ??? ]

^ Block? S. L.? Yogev? R.? Hayden? F. G.? Ambrose? C. S.? Zeng? W.? Walker? R. E. (2008). "Shedding and immunogenicity of live attenuated influenza vaccine virus in subjects 5?49 years of age". Vaccine . ?. 26 ?. 38: 4940?4946. DOI : 10.1016/j.vaccine.2008.07.013 . PMID : 18662737 .
^ "FDA Information Regarding FluMist Quadrivalent Vaccine" . U.S. ????? ?????? ??????? (???????? ???????) (FDA) . 16 ????? 2018. ????? ?? ????? ?? 2019-11-28 . ???? ???? ?????? 2019-11-27 .
^ "ACIP votes down use of LAIV for 2016-2017 flu season" . 22 ????? 2016. ????? ?? ????? ?? 2020-04-06 . ???? ???? ?????? 2016-07-14 .
^ ^? ^? "ACIP Reinstates FluMist for 2018-2019 Flu Season" . medpagetoday.com . MedPage Today, LLC. 21 ?????? 2018. ????? ?? ????? ?? 2020-04-06 . ???? ???? ?????? 2018-02-23 .
^ Midthun? Karen? Steven Masiello (17 ????? 2003). "CBER Approval Letter, Influenza Virus Vaccine, Live, Intranasal (FluMist)" . ????? ?????? ??????? (???????? ???????) (FDA). ????? ?? ????? ?? 2007-09-29 . ???? ???? ?????? 2008-07-06 .
^ "Fluenz Tetra EPAR" . ????? ??????? ????????? (EMA) . 21 ?????? 2019. ????? ?? ????? ?? 2019-11-28 . ???? ???? ?????? 2019-11-27 .
^ Belshe? R. B.? Edwards? K. M.? Vesikari? T.? Black? S. V.? Walker? R. E.? Hultquist? M.? Kemble? G.? Connor? E. M.? CAIV-T Comparative Efficacy Study Group (2007). "Live Attenuated versus Inactivated Influenza Vaccine in Infants and Young Children". New England Journal of Medicine . ?. 356 ?. 7: 685?696. DOI : 10.1056/NEJMoa065368 . PMID : 17301299 .
^ Jefferson? Tom? Rivetti? Alessandro? Di Pietrantonj? Carlo? Demicheli? Vittorio (1 ?????? 2018). "Vaccines for preventing influenza in healthy children" . The Cochrane Database of Systematic Reviews . ?. 2: CD004879. DOI : 10.1002/14651858.CD004879.pub5 . ISSN : 1469-493X . PMC : 6491174 . PMID : 29388195 .
^ "Nasal Spray Flu Vaccine in Children 2 through 8 Years Old" . ????? ?????? ??????? ???????? (CDC). ????? ?? ????? ?? 2014-10-28 . ???? ???? ?????? 2014-11-04 .
^ ^? ^? ^? AstraZeneca Inc. (2013). Product Monograph: FluMist . AstraZeneca Inc. ????? ?? ????? ?? 2014-07-23 . ???? ???? ?????? 2013-08-27 .
^ ^? ^? ^? ^? ^? ^? ^? "The Nasal-Spray Flu Vaccine (Live Attenuated Influenza Vaccine [LAIV])" . National Center for Immunization and Respiratory Diseases . 22 ????? 2008. ????? ?? ????? ?? 2009-11-26 . ???? ???? ?????? 2008-07-06 .
^ FDA Vaccines and Related Biological Products Advisory Committee (April 2007). "FluMist Live, Attenuated Influenza Vaccine Briefing Document" (PDF) . ????? ?? ????? (PDF) ?? 2018-01-26 . ???? ???? ?????? ????? 2020 . {{ ??????? ??? }}: ???? ?? ??????? ??: |????? ??????= ( ?????? )
^ "Update on Influenza A (H1N1) 2009 Monovalent Vaccines" . 9 ?????? 2009. ????? ?? ????? ?? 2020-04-06 . ???? ???? ?????? 2009-10-23 .
^ AstraZeneca's Nasal Flu Vaccine Approved In Europe ^{[
???? ??????
]} ???? ?????? 2020-04-06 ??? ???? ??? ??? ???? .
^ Influenza Virus Vaccine Composition and Lot Release , US Food and Drug Administration ???? ?????? 2020-04-06 ??? ???? ??? ??? ???? .

[cite_pmid|18662737-1] Block? S. L.? Yogev? R.? Hayden? F. G.? Ambrose? C. S.? Zeng? W.? Walker? R. E. (2008). "Shedding and immunogenicity of live attenuated influenza vaccine virus in subjects 5?49 years of age". Vaccine . ?. 26 ?. 38: 4940?4946. DOI : 10.1016/j.vaccine.2008.07.013 . PMID : 18662737 .

[FDA_Statement-2] "FDA Information Regarding FluMist Quadrivalent Vaccine" . U.S. ????? ?????? ??????? (???????? ???????) (FDA) . 16 ????? 2018. ????? ?? ????? ?? 2019-11-28 . ???? ???? ?????? 2019-11-27 .

[CDC2016Update-3] "ACIP votes down use of LAIV for 2016-2017 flu season" . 22 ????? 2016. ????? ?? ????? ?? 2020-04-06 . ???? ???? ?????? 2016-07-14 .

[MPT_18_Reinstate-4] ? ^? "ACIP Reinstates FluMist for 2018-2019 Flu Season" . medpagetoday.com . MedPage Today, LLC. 21 ?????? 2018. ????? ?? ????? ?? 2020-04-06 . ???? ???? ?????? 2018-02-23 .

[approval-5] Midthun? Karen? Steven Masiello (17 ????? 2003). "CBER Approval Letter, Influenza Virus Vaccine, Live, Intranasal (FluMist)" . ????? ?????? ??????? (???????? ???????) (FDA). ????? ?? ????? ?? 2007-09-29 . ???? ???? ?????? 2008-07-06 .

[ema.europa.eu-6] "Fluenz Tetra EPAR" . ????? ??????? ????????? (EMA) . 21 ?????? 2019. ????? ?? ????? ?? 2019-11-28 . ???? ???? ?????? 2019-11-27 .

[cite_pmid|17301299-7] Belshe? R. B.? Edwards? K. M.? Vesikari? T.? Black? S. V.? Walker? R. E.? Hultquist? M.? Kemble? G.? Connor? E. M.? CAIV-T Comparative Efficacy Study Group (2007). "Live Attenuated versus Inactivated Influenza Vaccine in Infants and Young Children". New England Journal of Medicine . ?. 356 ?. 7: 685?696. DOI : 10.1056/NEJMoa065368 . PMID : 17301299 .

[:0-8] Jefferson? Tom? Rivetti? Alessandro? Di Pietrantonj? Carlo? Demicheli? Vittorio (1 ?????? 2018). "Vaccines for preventing influenza in healthy children" . The Cochrane Database of Systematic Reviews . ?. 2: CD004879. DOI : 10.1002/14651858.CD004879.pub5 . ISSN : 1469-493X . PMC : 6491174 . PMID : 29388195 .

[9] "Nasal Spray Flu Vaccine in Children 2 through 8 Years Old" . ????? ?????? ??????? ???????? (CDC). ????? ?? ????? ?? 2014-10-28 . ???? ???? ?????? 2014-11-04 .

[Flumist_Canadian_Product_Monograph-10] ? ^? ^? AstraZeneca Inc. (2013). Product Monograph: FluMist . AstraZeneca Inc. ????? ?? ????? ?? 2014-07-23 . ???? ???? ?????? 2013-08-27 .

[QandA-11] ? ^? ^? ^? ^? ^? ^? "The Nasal-Spray Flu Vaccine (Live Attenuated Influenza Vaccine [LAIV])" . National Center for Immunization and Respiratory Diseases . 22 ????? 2008. ????? ?? ????? ?? 2009-11-26 . ???? ???? ?????? 2008-07-06 .

[12] FDA Vaccines and Related Biological Products Advisory Committee (April 2007). "FluMist Live, Attenuated Influenza Vaccine Briefing Document" (PDF) . ????? ?? ????? (PDF) ?? 2018-01-26 . ???? ???? ?????? ????? 2020 . {{ ??????? ??? }}: ???? ?? ??????? ??: |????? ??????= ( ?????? )

[CDC-AH1N1-13] "Update on Influenza A (H1N1) 2009 Monovalent Vaccines" . 9 ?????? 2009. ????? ?? ????? ?? 2020-04-06 . ???? ???? ?????? 2009-10-23 .

[foxbusiness-14] AstraZeneca's Nasal Flu Vaccine Approved In Europe ^{[
???? ??????
]} ???? ?????? 2020-04-06 ??? ???? ??? ??? ???? .

[fda-approval-lists-15] Influenza Virus Vaccine Composition and Lot Release , US Food and Drug Administration ???? ?????? 2020-04-06 ??? ???? ??? ??? ???? .

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