한국   대만   중국   일본 
????? ??? ???? ?????? - ????????? ????? ??? ???????

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????? ????? ?????? ???????? ( ??????????? : RNA virus )? ?? ????????? ???? ?????? ???????? ????? ?? ????? ?????? ???????? (??? ?????? ??????). [1] ??? ????? ?????? ????? ?????? ??????? ?? ????? ?????? ???????? ????? ??????? (ssRNA) ???? ?? ???? ?? ????? ?????? ???????? ????? ??????? (dsRNA) ?????? ??????? ?????? ????????? ???? ??????? ????? ?????? ???????? ??? ??? ???? ????? ???????? III? ???????? IV ????????? V ?? ????? ??????? ??? ???? ???? ???????? ??????? ????? ???? ??? ??????? ???????? ????? ?????? ????????. [2] ??????? ??????? ??????? ???? ?????? ??????? ????? ?????? ???????? ???? ?????? ? ?????????? ??????? ????? ???????? ? ???? ??????? ?????? ?????? .

??????? [ ??? ]

??????? ??? ???? ?????? ???? ??????? ???????? [ ??? ]

???? ????? ??????? ????? ?????? ???????? ????? ?????? ?? ????? ????? ?????? ??? ????? ?? ????? ?? ?????? ???????. ???? ????? ?????? ???????? ???????? ???? ??????? ????? ?????? ???????? ??????? ???????? ?????? ??????? ?????? ?????? ??????? ????? ???? ????? ?????? ???????? ???? ??????? ?????? ????? ?????? ???????? ?????? ??? ??? ?????? ??? ??? ???? ??????? ?????? ????????? ????? ?????? ???????? ???????? ??? ????? ?????? ???????? ??? ??????. ??? ??? ????? ???? ????? ?????? ???????? ??????????? ?? ??????? ???? ??????? ?? ???? ?????? ???? ????? ??? ???? ?? ???? ???? ???????? ????? ?? ???? ????? ?????? ???????? ??????????? ?? ??????? ???? ??????? ??????? ??? ????? ??? ????? ????? ??????? ??? ??? ???? ?????? ???? ???????. ??? ??? ?????? ???? ??? ?? ?????? ??? ?????? ?? ??????? ??????? ????????? ????? ???????. ?????? ??????? ????? ?????? ???????? ?????? ??????? ??????? ????? ?????? ???????? ???? ??????? ???????? ???? ????? ????? ?????? ?????? ???. [3]

??????? ??? ?????? ??????? [ ??? ]

??????? ??????? ????? ?????? ???????? ?????? ??????? ?????? ?????? ?? ????????? ????? ?? ????? ?? ??? ?????? (????? ?????????? ????????? ????????? ?????????) ???? ??? ??????? (???? ??? ???? ???) ?????? ????????? (??? ??????? ???? ????? ??????? ???????? ????????? ???..). ???? ????? ??? ???????? ?? ???: ??????? ??????? ??? ????? ?????? ?????? ??????? ?????? ???????? ??? ??????? ??????? ???????? ??????? ???? ??? ???? ????????? ?????? ?? ????? ???? ????? ?????????? ?? ?? ???? ?????? ???????. ??? ????? ?????? ?????? ??? ??????? ??????? ?????? ????????? ??????? ??? ??????? ????????. ?? ??????? ???????? ???? ???????? ???? ?? ????? ????? ??? ???????? ??????????? ????????? ???????? ?????? ?? ??????? ??? ?????? ??????? ??? ????????? ????? ???? ???????? ??? ??? ????? ??? ???? ??????? ?????? ?? ???? ??????? ????? ?????? ?? ??? ?????????.

?????? ?????? [ ??? ]

????? ??????? ????? ?????? ???????? ???? ???? ?????? ?????? ??????? ???????? ????? ?????? ???????? ????? ???????? [4] ???? ?????? ????????? ????? ?????? ???????? ???? ??????? ???????? ?? ????????? ?????. [5] ??? ??????? ??? ??? ????? ????? ?????? ??? ???? ???? ?? ??????? ???? ?????? ??????? ????? ?????? ????????? ??????? ?? ?????. ???? ????????? ???????? ????? ???? ???? ????? ??? ????? ?? ?????? ???? ????? ?????? ????? ??? ??? ????? ?????? (??????? ???? ?????? ????? ?????? ?????? ??? ???????) ???? ??????? ???? ???? ????? ????? ?????? ?????? ????? ??? ????????. [6] ???? ??? ????? ??????? ????? ?????? ???????? ???? ?????? ??????? ????????? ???????? ???? ??????? ?? ??? ??????? ??? ??????. [7] ??? ???? ??????: ???? ??????? ???? ???? ???????? ????? ?????? ???? ?? ????? ????? ?????? ????? ??? ????? ???? ???? ???? ????????? ???????. [8]

??????? [ ??? ]

??????? ?????? ??????? ??????? ????? ?????? ???????? ??? ???? ??????? ?????? ???????? ??? ??????? ????? ??? ?????? ???????.

  • ????? ??????? ????? ?????? ???????? ????? ??????? (???????? ???????) ?? ???? ??? ???? ??? ????? ?????? ?? ?????? ????? ?????? ????????? ????? ?? ???? ??????? ?????? ?? ????.
  • ???? ????? ??????? ????? ?????? ???????? ???? ??????? ???? ??????? (???????? ???????) ???? ??????? ????? ???? ???? ?????? ????? ?? ?????? ????????? ?????? ??? ?????? ???? ??????? ?????? ?????????? ????????? ???????? ???????? ?????????? ???????? ???????? ???????. ??? ??? ??????????: ????????? ????? ??????? ??? ????? ???? ???? ????? ?????? ???????? ???????? ?????? ????? ??????? ????? ??????? ???? ???? ????? ??? ????? ????? ?????? ???????? ???????? ??????.
  • ??? ?? ????? ????? ??????? ????? ?????? ???????? ???? ??????? ???? ??????? (???????? ???????) ?? ??? ????????? ????? ??????? ??? ????? ?????? ????? ?????? ???????? ???? ???????. ?? ??? ?? ????? ??????? ???? ??????? ????????? ????? ??????? ??? ????? ?????? ??? ???? ???????? ?? ???? ??? ?????? ???? ???? ???? ?????? ???? ??????? ?? ??? ????????? ?????? ??? ????????.

??? ????? ?? ?????? ????????? ???????? (???????? ???????) ?????? ??? ???? ???????? ????? ?? ????? ??????? ??? ???? ???? ????? ?????? ????? ????? ???????? ?? ???? ????? ????? ?????? ????? ?????? ???????? ???????? ???? ??? ????? ????? ????? ?????? ?????? ????? ?????? ??????? ?? ????? ????????? ???? ?????? ??? ??????? ??? ????? ?????? ?? ???? ????? ????????? ????? ??????? ?? ??????? ??????? ??? ????? ??????? ?????.

????? ??????? [ ??? ]

???? ?????? ?? ??????? ????? ?????? ???????? ????? ??? ????? ??????? ?????? ??? ???? ??????? ???????? ??? ????? ??? ??? ?????? ???????? [9] ????? ?? ??? ?????? ???? ??? ????? ?? ????? ????? ??????? ????? ?????? ???????? ?? ??????? ????????? ??? ????? ?????? ???????? ???? ??????? ???? ??????? (?????????? ?????????). ????? ????? ????????? ???????? ??? ????? ?????? ???????? ???? ??????? ???? ??????? ?????? ????? ??????? ?????? ????? ????? ????? ?????? ?? ???? ??? ????? ????? ??????? ??? ??????? ???????. [10] [11] ???? ????? ??????? ????? ?? ????????? ???????? ??????? ??????? ??? ????? ?????? ???????? ????? ??????? ?????????? ???????? ??????? ??? ????? ?????? ???????? ???? ??????? ???? ??????? (?????? ?????????? [9] ) ?????????? ??????? ??? ????? ?????? ???????? ???? ??????? ???? ??????? (???????). [12] ???? ????? ????? ??????? ????? ?????? ???????? ??? ????? ?????? ???? ?????? ?? ????? ???? ?? ???? ????????. ?? ???? ??? ??????? ???? ???? ?? ????????? ????????? ?? ??? ????? ??? ??????? ???????. ????? ????????? ??????? ?? ????? ??????? ?? ???? ???? ?????? ??? ?????. [12]

??????? [ ??? ]

  1. ^ MeSH , retrieved on 12 April 2008. ???? ?????? 16 ????? 2010 ??? ???? ??? ??? ???? .
  2. ^ "Listing in Taxonomic Order - Index to ICTV Species Lists" . ????? ?? ????? ?? 2009-11-06 . ???? ???? ?????? 2008-04-11 .
  3. ^ Nguyen M? Haenni AL (????? 2003). "Expression strategies of ambisense viruses". Virus Research . ?. 93 ?. 2: 141?50. DOI : 10.1016/S0168-1702(03)00094-7 . PMID : 12782362 .
  4. ^ Sanjuan R? Nebot MR? Chirico N? Mansky LM? Belshaw R (?????? 2010). "Viral mutation rates" . Journal of Virology . ?. 84 ?. 19: 9733?48. DOI : 10.1128/JVI.00694-10 . PMC : 2937809 . PMID : 20660197 .
  5. ^ Klein? Donald W.? Prescott? Lansing M.? Harley? John (1993). Microbiology . Dubuque, Iowa: Wm. C. Brown. ISBN : 978-0-697-01372-9 . {{ ??????? ????? }} : ?????? ??? ??????? |name-list-format= ?? ?????? ????? ??????? |name-list-style= ( ?????? )
  6. ^ Steinhauer DA? Holland JJ (1987). "Rapid evolution of RNA viruses" . Annual Review of Microbiology . ?. 41: 409?33. DOI : 10.1146/annurev.mi.41.100187.002205 . PMID : 3318675 .
  7. ^ Boutwell CL? Rolland MM? Herbeck JT? Mullins JI? Allen TM (?????? 2010). "Viral evolution and escape during acute HIV-1 infection" . The Journal of Infectious Diseases . 202 Suppl 2 ?. Suppl 2: S309?14. DOI : 10.1086/655653 . PMC : 2945609 . PMID : 20846038 .
  8. ^ Tuplin A? Evans DJ? Simmonds P (?????? 2004). "Detailed mapping of RNA secondary structures in core and NS5B-encoding region sequences of hepatitis C virus by RNase cleavage and novel bioinformatic prediction methods" . The Journal of General Virology . ?. 85 ?. Pt 10: 3037?47. DOI : 10.1099/vir.0.80141-0 . PMID : 15448367 .
  9. ^ ? ? Barr JN? Fearns R (????? 2010). "How RNA viruses maintain their genome integrity" . The Journal of General Virology . ?. 91 ?. Pt 6: 1373?87. DOI : 10.1099/vir.0.020818-0 . PMID : 20335491 .
  10. ^ Hu WS? Temin HM (?????? 1990). "Retroviral recombination and reverse transcription". Science . ?. 250 ?. 4985: 1227?33. Bibcode : 1990Sci...250.1227H . DOI : 10.1126/science.1700865 . PMID : 1700865 .
  11. ^ Bernstein H? Bernstein C? Michod RE (????? 2018). "Sex in microbial pathogens". Infection, Genetics and Evolution . ?. 57: 8?25. DOI : 10.1016/j.meegid.2017.10.024 . PMID : 29111273 .
  12. ^ ? ? Su S? Wong G? Shi W? Liu J? Lai AC? Zhou J? ?????? (????? 2016). "Epidemiology, Genetic Recombination, and Pathogenesis of Coronaviruses" . Trends in Microbiology . ?. 24 ?. 6: 490?502. DOI : 10.1016/j.tim.2016.03.003 . PMID : 27012512 .