??? ????? ??? ?????? . ????? ?? ???? ??? ?????? ??? ?? ??????? ???? ? ??? ??? ????? ???? ?? ???? ??????? ?????? ??????? ????????. ???? ????? ????? ??? ??????? ??????? ?? ?????? ??????? ????. ( ????? 2020 )

????? ????????? ? ?? ?????? ?????? (???????????: Diglyceride) ????????? ( DAG ) ? ?? ??????? ????? ?? ??????? ?? ??????? ??????? ?????? ???????? ????? ???????? ?? ???? ????? ???? . ^{[1] [2] [3]} ???? ????? ???????? 1,2-?????? ?????? ? 1,3-?????? ??????.???? ?? ???? DAGs ????? ????? ?????? ?????? ??????? ???? ????????? ?? ??????? ??????? .?? ??? ????? ?????? DAG (???? 1,3-DAG) ??? ???? ???? ????? ?????? ????? ?????? ??? ??? ????? ?????? ?? ????? ? ?? ?????? ?????? ????? ???? ????? 200 ????? ????? ?????? ?? ??????? ??? ????? ?? ????? ?????????? ???? ??? 2009 . [1]

??????? [ ??? ]

????? ??????? ????????? ?????? ??????? ?? ?????? ?? ???? ?????? ??????? ???? ????? ~ 1-6? ? ?? ?? ???? ??? ???? ????? ???? 10?.??? ????? ??????? ??????? ???? ????? ?? ???? ????? ???? ???????? ??? ?????? ???????? ?????????. ?? ???? ?????? ????? ???? ??? ???? ????? ?????? ?? ???????.

???? ????? ?????? [ ??? ]

??????? ?????????? ???? ??? ?? ???? ?? ????? ????????? ( E471 ) ? ?? ?????? ?????? ????? ?????? ??? ?? ???? ?????????.?? ???? ????? ??????? ?? ???????? ???????? ?????? ????????? ??????? ??????? ??????? ???????? ??? ???????? ?? ?????? ???????? ?????????.?????? ?? ??? ??????? ?? ?????? ??????? ?????????? ?????? ???? ????? ????? ???????? ??????? ?????? ???????? ???????? ?????????? ????????? ?????? ??????? .

??????? ??????? [ ??? ]

????? ?????? ????? c [ ??? ]

?? ???????? ?????????? ??????? ? ???? ????? ?????????? ?????? ???? ?????? ??? ???? ?????? ?????? ???????????? 4,5-?????????? (PIP2) ?????? ????? (PLC) ??????????? (????? ????? ???????) ????? ?? ???? ??? ??????? ???? ????????? ????? ?????? (IP3).??? ????? ?? ?? ????? ?????? ??????????? ????? ?? ??????? ??????? ? ??? ?? ?????? ?????? ???? ???? ?????? ???????? ? ???? ?????? ??????? ????? .???? IP3 ????? ?????? ????????? ?? ?????? ????????????? ??????? ? ????? DAG ????? ?? ???? ???????? ??????? ????? (C (PKC.???? ????? DAG ?? ?????? ????? ?????? PKC ?? ??????? ??????? ??? ???? ????????.

????? munc-13 [ ??? ]

(munc-13 : ?? ?????? ????? ?? RIM ??? ??????? ?? ????? ??? ??? ?? ?????? ??????? ???? ???? ????????? ???????? .)

??? ??? ?? ????? ???? ??? ???????? ??????? ??? ????? ???????? ?? ???? ????????? ?? ????? ?????? ?? ??? ??????? Munc13.???? ?????? DAG ??????? C1 ?? Munc13 ?? ????? ?????? ????????? ???????? ??? ???? ??? ????? ????.

???? ????? ??????? ????????? ?????? ?????? ?????? ??????? ??????? ?????.

???? [ ??? ]

???????? ??? ????? PKC ? ????? ????? ????????? ??? ??? ?? ??????? ?????? ?? ??????:

• ???? ???????????????.
• ????? ??? 2- ???????????? ???????? ????? ?????????? ????? .
• ???? ?????? ????? ?? ????? ??????? ??????? ???????? ?????????? ??????? (TRPC ? TRPC3 / 6/7).

??????? ??????? [ ??? ]

???? ????? ?????? ?????? ????????? -3 ??????? ?????? ?????? ?? ????? ???????? ?????? ??????? ??? ??? ?????? ???? ????? (???? ?? ????????? ????? ?? ????? ??????? ??????? ).??? ????? ???? ???????? -3 ?????? ?? ????-????? ? ( ???? - CoA) ?????? ??? ?????????????? ????? ??? ??? ??? ?????? ?? ???? ??? ?? ????- CoA ?????? ??? ???????????? .?? ??? ????? ??????? ?? ??? ?????????? ?????? ?????? ??????.

????? ?????? ???????? ???? ????? ?? ?????? ???????? .????? ???? ?? ???? ?????? ?????? ?????? ?????? ????????? ??? ????? ??? ?????? ???????? ???????? ??? ????? ???? ?????? ?? ?????? ?????? ?? ????? ????? ??? .(???? ??????? ???????? ??????? ???????? ?????? ????????? ?????? ?? ???? ???????? ????? ?? ????????.)????? ????????? ?? ????? ??? ?????? ???????? (?????? ????????) ? ????? ????? ?? ????? ??? ???? ???? ??? ????? ????????? ??? ????? ????? ????????? ?????? ??????????.

????? ??? ????? ????????? ??? ?????? ??? ??? ????????????? ???? ????? ????? ??? ??? ???? ???? ?? ???? C-1 ??? ??? ???????? ???? ???? ??? ???? ?? ???? C-2.

???? ????? ?????? ?????? ??? ??? ???????????? ?????? ?????? ?????? ?????.

?????? ????????? [ ??? ]

?? ???? ????? PKC-θ ?????? ????? ????????? ??? ?????? ????????? ?? ??????? ?? ???? ????? ???? PI3K ??????? ?? IRS1.???????? ?? ???? ????? PKCε ?? ???? ????? ????????? ??? ?????? ????????? ?? ?????.

????? [ ??? ]

1/ https://en.wikipedia.org/wiki/Diglyceride

2/ https://en.wikipedia.org/wiki/Diglyceride

3/ https://en.wikipedia.org/wiki/Diglyceride

4/ https://en.wikipedia.org/wiki/Diglyceride

5/ https://en.wikipedia.org/wiki/Diglyceride

6/ https://en.wikipedia.org/wiki/Diglyceride

7/ https://en.wikipedia.org/wiki/Diglyceride

8/ https://en.wikipedia.org/wiki/Diglyceride

???? ???? [ ??? ]

• ???? ??????? ?????? ??? ????????? ???????
• ????? ???????
• ??? ????
• ??? ?????
• ???? ?????
• ???? ?????
• ???? ??????
• ???? ????? ?????

• ????? ????????
• ????? ???????? ???????
• ????? ??? ??????? ?????? ????????

??? ??? ?? ????:Wikidata2 ??? ????? 69: assign to undeclared variable 'isvalid'.