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????? POMC
?????? 5443
HUGO 9201
????? 176830
RefSeq NM_000939
???????? P01189
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?????? ??????????? Chr. 2 p23

?????????? ??????????? Endorphin ? ??? ????? ????? ?? ????? ???? ??????? . [1] [2] [3] ??? ???? ?????? ?? ?????? ?????? ????? ??????????. ????? ?????????? ???? ?????? ?????????? ???????? ??? ?? ??????? ???? ????? ???? ≪???????????≫ ????? ?? ?????? ????? ?? ???????? ????? ????????? ????? ≪?????????≫. ?????? ??????????? ??? ????? ?????? ????? ?????? ??????? ???????. ?????? ??????? ?? ?????????? ??????????? ??????? ?? ???? ?????? ??? ????????? ?????????? ???????? ?????? ?? ???????. ????? ?? ???? ????? ?? ???? ????? ????? ?? ?????.

??? ????? ??????? ??????? ?????? ?? ?????????? ??????????? ?????? ????? ?? ?????????? ??? ????? ?? ?????? ???????? . ?????? ≪???????? ? ????≫ ?? ???? ??????????? ???? ??? ??????? ?????. ????? ??? ??? ????? ?? ?????????? ?? ?????? ??? ????? ???????? ? ??? ??? ????? ???? ???? ????? ??????? ??? ???? ?? ???? ?????? ??????. ????? ???????? ? ???? ??????? ??? ??? ??????? ?????? ???? ????? ????? ???????? ?? ACTH ?? ?????? ???? ?? ????? ???????? ??? ????? ??? ?????????? ??? ??? ?? ???????? ????? ?? ????? ??? ????? ????? ?? ???????.

???? ?? ?????????? [ ??? ]

??? ?? ?? ??????? ?????? ????? ?????????? (Endorphins) ?? ??? 1975? ??? ??? ?? ??? ?????? ????? ???? ???? ??????? ?? ??? ??????? . ??????????? ?? ?? ?????? ?? ?????? ?????????? ???????? (Polypeptides) ???? ????? ?????? ???????? ?? ????? ???????? ??????? ??? ?????? ?????? . ??? ????? ?????????? ?? ????? ?????? ?? ?? ????? ???????? ? ???? ????? ????????? ????? ?? ?????? ???????? ???? ?????? ??????? ???????? ????? ???? ???? ??? ??? ??????? ??????? ????? ( ??????? ) ????????? ???????? ? ??? ?? ?????????? ???? ???? ??????? ?? ????? ?? ???? ??? ??????? ??? ?? ????? ?? ??????? ??????? ??????? ?????????. ???? ?????? ???? ?? ????? ????? ?? ?????????? ?? ?? ?????? ?????? ??? ?? ???? ???????? ??? ?????? ??? ???????? ??? ????? ?? ????? ????? ?? ??????? ???????? (?????? ????? ???????). ?????? ?????????? ??????? ??? ?? ??????? (Stress) ??????? ?????? ??? ?????????? ?? ????? ?????? ??????? ???? ???????? ?????? ?????? ??????? ? ??? ?? ?? ??????? ????? ?????????? ???? ?????? ??? ????? ??????? ??????? ????????.

????????? ??????? ?? ????? ?????????????????????
????? ??? ??????????

????? ????? ?????? ??? ????? ?????????? ?? ???? [ ??? ]

???? ?????????? ??????? ????? ?????? ??????? ??????? ????? ???? ???? 20????? ?????? ??? ???? ?? ???? ????? ?????? ????? ??? ??? ????? ????? ????? ?????. ??? ????? ????? ?????? ?????? ???? ?? ???? ??? ????? ?????? ???? ???????? ??????? ?? ??? ???????? ??? ????? ?? ?????? ?? ???? ????? ???? ????? ?????? ????? ??????. ????? ???? ?? ??????? ?? ??????????? ?? ??????? ?? ???? ?????? ???????? ???? ???? ??? ???????? ????????? ??? ????? ????? (High Runner's)? ??? ????? ?? ?????????? ??????? ?? ????? ????? ?????????? ??? ???? ????? ?????? ???? ???? ???? ?????????? ??? ????? 10 ????? ?? ?????? ?????? ????? ?? ?????? ??? ????? 20 ? 30 ????? ??? ????? ????? ?????? ???????? ??????? ?? ????? ???? ??????????. ??????? ?? ???? ?? ???? ?????? ?????? ?? ??????? ?????????? ????? ?????? ??? ?????? ?????? ?????? ? ??? ???? ??? ??? ????? ?????? ???? ???? ????????? ??? ?????? ??????? ?? ??? ?????.

??? ????? ??????? ?? ???? ?????????? [ ??? ]

????? ????? ??????? ??????? ???????? ?? ???? ??????? ?? " ???? ????????? "? ???? ???? ??? ?????? ?????? ?????????? ???? ????? ??? ??? ????? ???? ???? ??????? ???? ????? ???? ???????. ??? ??? ??? ???? ??????? ?????? ???? ??????? ??? ?????????? ???????? ?? ???? ??????? ??? ??? ??? ????????? ??????? ??????? ??? ?????? ???????? ?? ???? ???? ?? ????? ?????????? ???? ??????? ??? ????. ????? ??????? ?????? ??????? ????????? ???????? ???? ???? ?????? ?????? ???? ???.

  • ???? ???????? ?????? ? ≪????? ????? ??? ??? ?????? ????? ????? ?????? ??? ???? ???? ?? ??????????. ???? ??? ?? ???? ????? ????? ??? ???? ???? ????????? ????????? ??? ???? ??????. ????? ???? ?? ????? ?????????? ???? ???? ??? ???? ?????? ???????? ??????? ???? ??? ?????? ????? ??? ??????? ??? ?? ???? ????? ???????? ??? ???????≫.
  • ???? ??????? ?????? ? ≪?? ??? ????? ?????? ????? ??? ????? ????? ?? ?????? ??????? ? ??? ???? ????? ??????????. ??? ?? ?????? ????? ?????? ?????? ?????? ??????? ????? ?? ??????? ?????? ???????? ????? ????? ??????≫.
  • ???? ??????? ???? ?????? ? ≪?????? ???? ???? ?? ???? ??????? ???? ???????. ??? ???? ??? ?????? ????? ??? ????? ??????????. ???? ?? ??? ??? ???? ???? ????? ???? ????? ????? ???? ?? ???? ???? ????? ?????? ??? ??????? ???????? ≫.
  • ???? ????? ???????? ???? ???? ?????????? ???? ??????? ???? ?????? ? ≪?? ???? ??????? ?????? ?????? ?????? ?????? ????? ????? ? ???? ?? ??? ??????? ????? ?????? ????? ????? ??? ??? ???? ????? ?????? ???? ?????????? ????? ???????? ???? ??? ???? ???? ????? ????? ????. ???? ???? ????? ?????? ?????? ?? ??????? ? ???? ???? ????????? ???? ???? ?? ????? ???? ???? ?????? ??????????? ????? ???? ?????? ???? ???????? ??? ?????? ?????? ?? ??????≫.
  • ??? ?????? ?? ???? ????? ??? ?????? ????? ????????? ??? ?????? ??? ????????? ???? ??? ????????? ???? ?? ????? ?? ????? ??????????? ???? ?? ??? ????? ???? ???? ??? ????????? ?? ????? ??? ??? ??????? ???????? ?????? ?? ????? ????? ????? . ???? ????? ?? ??????? ????? ?? ???? ????? ?? ?? ???? ?? ????? ??????????? ???? ?? ???? ?? ????? ??????? ???? ?? ??? ????? ?? ?????? ?????? ????? ??? ??? ?????? ??????.

?????? [ ??? ]

  • ?????? ???????: http://www.marefa.org
  • Stryer. Biochemistry .3rd ed. Freeman
  • Murry, Granner, Mayes, & Rodwell. Harper's Biochemistry . 25th ed. Lang

????? [ ??? ]

  1. ^ Simeon D? Knutelska M (????? 2005). "An open trial of naltrexone in the treatment of depersonalization disorder" . Journal of Clinical Psychopharmacology . ?. 25 ?. 3: 267?270. PMID : 15876908 . ????? ?? ????? ?? 2017-10-22.
  2. ^ "Role of endorphins discovered" . PBS Online: A Science Odyssey: People and Discoveries . Public Broadcasting System. 1 ????? 1998. ????? ?? ????? ?? 2019-05-14 . ???? ???? ?????? 2008-10-15 .
  3. ^ Stefano GB? Pta?ek R? Ku?elova H? Kream RM (2012). "Endogenous morphine: up-to-date review 2011" (PDF) . Folia Biol. (Praha) . ?. 58 ?. 2: 49?56. PMID : 22578954 . ????? ?? ????? (PDF) ?? 2018-03-28. Positive evolutionary pressure has apparently preserved the ability to synthesize chemically authentic morphine, albeit in homeopathic concentrations, throughout animal phyla. ... The apparently serendipitous finding of an opiate alkaloid-sensitive, opioid peptide-insensitive, μ3 opiate receptor subtype expressed by invertebrate immunocytes, human blood monocytes, macrophage cell lines, and human blood granulocytes provided compelling validating evidence for an autonomous role of endogenous morphine as a biologically important cellular signalling molecule (Stefano et al., 1993; Cruciani et al., 1994; Stefano and Scharrer, 1994; Makman et al., 1995). ... Human white blood cells have the ability to make and release morphine