?? ?????????? ???????? ?????
| ???????????
|
|
|
|
 ???????????
|
| ?????
???????
|
| 3,5,7,8-tetrazabicyclo[4.3.0] nona-3,5,9-trien-2-one
|
| ????? ?????
|
|
| ?????
|
|
| ???????? ??????
|
| ??? ??????? ????? ?????
|
C(USA)
|
| ??? ????? ??????
|
tablet (100, 300 mg)
|
| ?????? ??????
|
| ????? ????
|
78±20%
|
| ??? ???????
|
Negligible
|
| ??????? (???) ??????
|
hepatic (80% oxypurinol, 10% allopurinol ribosides)
|
| ??? ????? ??????
|
2 hours (oxypurinol 18-30 hours)
|
|
| ???????
|
| CAS
|
315-30-0
|
| ? ? ?
|
M04
M04AA01 AA01
|
| ??? ???
|
CID 2094
|
| ECHA InfoCard ID
|
100.005.684
 |
| ??? ???
|
APRD00435
|
| ??? ??????
|
2010
|
| ?????? ??????
|
63CZ7GJN5I
 Y
|
| ?????
|
D00224
|
| ChEMBL
|
CHEMBL1467
|
| ?????? ????????
|
| ?????? ??????????
|
C
5
H
4
N
4
O
|
| ?????? ????????
|
136.112 g/mol
|
|
InChI=1S/C5H4N4O/c10-5-3-1-8-9-4(3)6-2-7-5/h1-2H,(H2,6,7,8,9,10)
[1]
|
|
|
????? ?????
-
?????
 |
????????????
(
???????????
:
allopurinol
)?
- ?????? ?????? ???? ?????? ??????? ????? ?? ?????? ????? ?????? ?????? ?? ???? ??????? ?? ??? ????? ?????? ????? ??? ?? ???? ?? ???? ??? ???
??????????
?? ?????????????.
- ???? ?? ???? ????? ????? ?? (
???????????
:
xanthin oxidase
)? ???????? ???? ????? ??? ??????? ?????? ?? ????? ??????? ??????? ?????????? ????? ???? ????? ????? ????????.
- ?????? ?? ????? ????????? ???? ???? ???? ??? ??????? ????????? ??????? ??? ???? ??? ????? ?? ??? ???????.
- ???? ??? ??????? ?? ??? ???????.
- ???? ??? ?????? ????? ????? ??
?????
.
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?????? ????????
[
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???????????
[
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- ??????? ?? ???? ?????? ??????? ??????? ???????? ?? ???????? ?????? ???? ??? ?????.
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???????
.
????????? ????????
[
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???? ????? ???? ?? 10%
- ?????: ??? ????? ????? ????? ???? ????? ?????? ?? ????? ?? ??????? ??????? ????? ? ??????.
???? ????? 1 ? 10%
???? ????? ??? ?? 1%
??? ?????? / ????????
[
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- ??? ???? ????? ???? ????? ?? ??? ?????? ??? ??? ????? ?????? ???? ?????
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.
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[
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???????????
??
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.
- ???? ?????? ????? (?????? ????? ??
?????????
) ?? ???? ???? ???? ??????? ???????.
- ???? ??????? ?????????? ???? ??? ??????? ???? ??????? ??????? ??? ???????? ????.
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[
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- ????? ????? ??? ????? ?????? ???? 1 ? 2 ????? ?? ????? ??? ?????? ????? ???????? ??????? ???? 1 ? 2 ?????.
- ???????? ??????: ???? ????? 80% ?? ?????? ??? ?????? ??????? ????? ?????? ?????? ????? ??? ???? 30 ? 120 ????? ??? ??????.
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- ??????: ???? ??? ????? ????? 1.6 ???? / ??? ????? ??? ???? ??????.
- ???????? ?????????: ??? ?? 1%.
- ?????????: ?????? ????? 75% ?? ?????? ?????
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- ????? ???????: 18 ? 30 ????.
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- ???????: ?? ???? ?? ???????????? ???????? ??????? ?????? ??????? ????????.
- ???? ????? 10% ?? ?????? ????? ??????? ?????? ??????? ????? ??? ?? 10% ???? ?? ????? ??? ??????? ???? 45 ? 65% ???? ??? ???
????? ???????
.
??????
[
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]
- ??????? ??? ??? ?? 6 ?????: ???? ?????? ????? 150 ??? / ????? ??? 3 ?????.
- ??????? ???? 6 ? 10 ?????: ???? ?????? ????? 300 ??? / ?????.
- ??????? ??? 10 ????? ?????????: ???? ?????? ????? ???? ?? 300 ??? / ?????.
- ???????? ????? ????????? ????????: ???? ?????? ????? 600 ? 800 ???/ ????? ???? ??? 2 ? 3 ????? ???? 2 ? 3 ????.
- ??????:
- ????: ???? ?????? ????? 200 ? 300 ??? / ?????.
- ????: ???? ?????? ????? 400 ? 600 ??? / ?????.
- ???????: ???? ?????? ????? ????? ????? 100 ??? / ?????? ??? ?? ???? ??? ?? ???? ??? ????? ??? ????? ?????? ???????.
- ??? ????? ????? ??? ?????? ?????? ??????? ??????? ???????.
????????
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?????????? ??????????
[
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- ?????: 100 ???? 300 ???.
- ????? ????: ??? ??????? ????? ?????? 5 ??? / ??? ???? ???? 14 ????? ????????.
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???? ?????? ?? ??????? ????????? ?.???? ??? ?????? ??????? - ?.????? ???? ?????? ??????? ??? ????? ??????.
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??? ??????? ?? ?????? ?? ????? ??????? ????????? ??????? ???. ?????? ????
??? ??????
.
