ADO Den Haag and Heerenveen will join Vitesse and Utrecht in the play-offs for the last Europa League spot despite mixed fortunes on the final day.
Former Eredivisie champions FC Twente have been relegated from the league after a thumping 5-0 defeat at Vitesse on Sunday.
Jorrit Hendrix's impressive late strike earned a point for Dutch champions PSV Eindhoven in a 2-2 draw against Roda.
Bryan Linssen scored twice in the second half as Vitesse won 7-0 against 10-man Sparta Rotterdam on Saturday.
PSV hit back from two goals down to win 3-2 at AZ Alkmaar and extend their lead at the top of Eredivisie to 10 points.
PSV Eindhoven maintained their dominance of the Eredivisie with a 5-1 win over NAC Breda on Saturday.